DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox7 and Sox15

DIOPT Version :9

Sequence 1:	NP_035576.1	Gene:	Sox7 / 20680	MGIID:	98369	Length:	380	Species:	Mus musculus
Sequence 2:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	376	Identity:	118/376 - (31%)
Similarity:	166/376 - (44%)	Gaps:	107/376 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    34 RPSGDKS---SESRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYV 95
            ||.|.:|   .||||||||||||||||.|||:||.:|||||||:|||||||.|::||...:||||
  Fly   201 RPGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYV 265

Mouse    96 DEAERLRLQHMQDYPNYKYRPRRKKQGKRLCKRVDPGFLLSSLSRDQNTLPEKNGIGRGEKEDRG 160
            :||||||:.||.::|||||||||:||.|  .:.:.||                     |:::...
  Fly   266 EEAERLRVIHMTEHPNYKYRPRRRKQSK--LRAMQPG---------------------GKEQSES 307

Mouse   161 EYSPGATLPGLHSCYREGAAAAPGSVDTYPYGLPTPPEMSPLDALEPEQTFFSSSCQEEHGHPHH 225
            ..:||.           |.:.:...:.|.|....:....:|.|    |.|  .:|..:.||.
  Fly   308 SPNPGT-----------GGSKSNPKLATPPLATASSSYTTPTD----EST--CNSTNQNHGQ--- 352

Mouse   226 LPHLPG----PPYSPEFTPSPLHC------SHPLGSLALGQSPGVSMMSSVSGCPPSPAYYSHAT 280
              ..||    .|..|.::||.:.|      :..:.|||             :.|||:....|..|
  Fly   353 --STPGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLA-------------ANCPPALLNESSPT 402

Mouse   281 YHPLHPNLQAHLGQLS-PPPEHPGFDTLDQLSQVELLGDMDRNEFDQYLNTPGHPDSAAGVGTLT 344
            ......:|.  |.:|: |.|........::|::.|     ::|:..|     ....|..|:...|
  Fly   403 GGGYDNSLL--LKKLTKPSPSRAAKSRQEKLAKSE-----EKNKGSQ-----SQGQSQQGIYAAT 455

Mouse   345 GHVPLSQGTPTGPTETSLISV-----------LAD----ATATYYNSYSVS 380
                    .|..||..::::.           |.|    ...|:|...|||
  Fly   456 --------YPLAPTSVAVVAARGMYVTCNNRGLLDHGHSVKGTFYPPVSVS 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox7	NP_035576.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..43		4/11 (36%)
		SOX-TCF_HMG-box	44..115	CDD:238684	52/70 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..167		3/27 (11%)
		Sox_C_TAD	175..378	CDD:288887	44/228 (19%)
		Required for beta-catenin-binding	323..328		1/4 (25%)
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	52/70 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5927
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm42771
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.940