Protein Alignment ERCC2 and Xpd

DIOPT Version :10

• Sequence 1: NP_000391.1
• Gene: ERCC2 / 2068
• HGNCID: 3434
• Length: 760
• Species: Homo sapiens
• Sequence 2: NP_726036.2
• Gene: Xpd / 37414
• FlyBaseID: FBgn0261850
• Length: 769
• Species: Drosophila melanogaster
• Alignment Length: 758
• Identity: 521/758 - (68%)
• Similarity: 636/758 - (83%)
• Gaps: 1/758 - (0%)

Human     1 MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPL 65
            |||:||||||||||:||||||::||.||||:||||||.:||||||||||.:||:||:||...:|.
  Fly     1 MKLSVDGLLVYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPE 65

Human    66 EVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDV 130
            .|.||||||||||||||||.||:.|:.:||:......||.||.||||||:||||||:..|.||.|
  Fly    66 TVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAV 130

Human   131 DGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLA 195
            ||||:.|||||:|.:::.||..|.|:::|.|...|:|..||.|:|::||||..||.:.|||||||
  Fly   131 DGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLA 195

Human   196 RYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQ 260
            ||:|.||::||||||||||||||.:||||::|::.|||||||||||||||||||.:.|||::|..
  Fly   196 RYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERST 260

Human   261 GNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRT 325
            ..|..|.|.|..|:|.|..||.:||:|:|:||::||..|:||..|||||||::||.|.|||:||.
  Fly   261 NALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRN 325

Human   326 AEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITD 390
            |:|||.||||.:||:|.||||.|||||||..||..::.::||:|||||||||||.|||.||||:|
  Fly   326 ADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISD 390

Human   391 LADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVI 455
            |.::..|||:.:||||||||.||||||||||||:|||::||||||||:|:|:|:.|||.|||:|:
  Fly   391 LTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVV 455

Human   456 ITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNY 520
            ||||||||:|:|||||||.||.|::|||||||.||.|||:.:|||||.||||||||||.||||||
  Fly   456 ITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNY 520

Human   521 GNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQ 585
            |.||:|::..||||||.|||||.|:||.|||||:|||::.:.|.|||||||||.||||.||..|.
  Fly   521 GQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYV 585

Human   586 EACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIREND 650
            :||:.||||:||:|||||||||:||.|||||||:|||:||||||||||||||:||||||||||||
  Fly   586 KACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIREND 650

Human   651 FLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQ 715
            |||||||||||||||||:|||||||:|:||||||:|.|||.:||:||||||.|:..||:.:|.||
  Fly   651 FLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEAVQ 715

Human   716 VAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQ 758
            :|:.:||:|||||.||||||:|||:|.|||:.|. :::|:.||
  Fly   716 LARRWLRRMAQPFTREDQLGISLLTLAQLENMEQ-EKLERQAQ 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERCC2	NP_000391.1	rad3	7..708	CDD:273169	486/700 (69%)
		DEAH box	234..237		2/2 (100%)
		Mediates interaction with MMS19	438..637		146/198 (74%)
		Nuclear localization signal. /evidence=ECO:0000255	682..695		8/12 (67%)
Xpd	NP_726036.2	rad3	7..717	CDD:273169	491/709 (69%)