DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox3 and cic

DIOPT Version :9

Sequence 1:	NP_033263.2	Gene:	Sox3 / 20675	MGIID:	98365	Length:	450	Species:	Mus musculus
Sequence 2:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	107/557 - (19%)
Similarity:	164/557 - (29%)	Gaps:	201/557 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse    31 PPELPARRP----LSTTPTESPG----------------------------------------LF 51
            ||::|....    :.:.|..|||                                        :|
  Fly  1086 PPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAAAAVANQRQKQQQEEPDDQLDDDVF 1150

Mouse    52 TVAAPAPGAPSPPATLAHLLPAPAMYSLLETELKNPVGPPTPAAGTGVPAAPGAAGKSGANPAGG 116
            ....|...|.|...|.|..||.... ::.:.|..:..|      ..|.||...|..:|.:..|..
  Fly  1151 ETTTPGISANSKKQTAAMRLPTHNS-NIRKLEECHDDG------AAGAPATSAAKRRSQSLSALQ 1208

Mouse   117 ANAGNGGSGGANGGGGGGGGGGSDQDRVKRPMNAFMVWSRGQRRKMALENPKMHNSEISKRLGAD 181
            .........||    .|...|.....:::|||||||::|:..|:.:..::|...|..:||.||..
  Fly  1209 QQQQQQQQAGA----AGTAAGQPANKKIRRPMNAFMIFSKKHRKMVHKKHPNQDNRTVSKILGEW 1269

Mouse   182 WKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKY--RPRRKTKTLLKKDKYSLPGGLLPPGAAAAAA 244
            |..|...:|..:.:.|..::..|.|.:|::|:  :.|||:.|           ....||..|:.|
  Fly  1270 WYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDRRKSST-----------STATPGGKASGA 1323

Mouse   245 AAAAAA-----------------AASSPVGVGQ-----------------RLDTY--------TH 267
            |....|                 ..|:|.|.|.                 .:|.|        |.
  Fly  1324 AGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSCGGQGISSDLQGDIIPLTIDNYNSTCDEAPTT 1388

Mouse   268 VNGWANGAYSLVQEQLGYAQPPSMSSPPPPPALPQMHRYDM-------------AGLQYSPMMPP 319
            ::...||...|::.:|...:...|...........:.:.|:             ....|....|.
  Fly  1389 ISMKGNGNGKLMKNELPSDEDEQMLVVEEEQQQQTVKKIDLHCRERVNDSDMDDTPFDYRKQQPE 1453

Mouse   320 GAQSYMNAAAAAAAASGYGGMAPSAAAAAAAAYGQQPATAAAAAAAA-----------AAMSL-- 371
            ..|    .:|...:.||..|.|.:|...:.   |::..|....|..|           ..||:
  Fly  1454 ANQ----RSAEEHSTSGANGQAINAPPLSG---GEREITLKPKAIKAHPVLESNMLPYTQMSIYT 1511

Mouse   372 --------------GPMGSVVKSEPSSPPPAIASHSQRACLGDLRDMISMYLPPGGDAADAAS-- 420
                          .|.|...||.|.||..:                       ||...||.|
  Fly  1512 QYTSPKNPIGVTPFQPTGGAFKSMPISPKGS-----------------------GGKPEDAGSLQ 1553

Mouse   421 ------------PLPGGRLHGVHQHYQGAGTAVNGTV 445
                        |.|       ::...|:|:|..|.|
  Fly  1554 AHIKQEDIKQEPPSP-------YKLNNGSGSASGGGV 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox3	NP_033263.2	SOX-TCF_HMG-box	143..214	CDD:238684	23/72 (32%)
Sox3	NP_033263.2	SOXp	213..306	CDD:289133	22/136 (16%)
cic	NP_001262755.1	DUF4819	349..431	CDD:292708
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	23/70 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910