DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox12 and Sox15

DIOPT Version :9

Sequence 1:	NP_035568.1	Gene:	Sox12 / 20667	MGIID:	98360	Length:	314	Species:	Mus musculus
Sequence 2:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster

Alignment Length:	296	Identity:	80/296 - (27%)
Similarity:	129/296 - (43%)	Gaps:	83/296 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    18 PGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQ 82
            || |..::.|:|        ..|:|||||||||::.||:|:.|:.||:|||::||.||::|:.|.
  Fly   202 PG-GTQSKSAKE--------SRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLT 257

Mouse    83 DSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGG----------GGGGSRLK 137
            ..::.|:|.||||||:.||.::|:||||||::.:   :|.|...|||          |.|||:..
  Fly   258 PQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQ---SKLRAMQPGGKEQSESSPNPGTGGSKSN 319

Mouse   138 PGPQLPGRGGRRASGGPLGGGAAA---PEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGP 199
            |....|          ||...:::   |.|:.           ...:..:...:..|.|...: |
  Fly   320 PKLATP----------PLATASSSYTTPTDES-----------TCNSTNQNHGQSTPGGLYEQ-P 362

Mouse   200 AERAQGPSGEGAAASAAS------------PTLSEDEEP-----------------------EEE 229
            .:....||.....::|.|            |.|..:..|                       :..
  Fly   363 LKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGYDNSLLLKKLTKPSPSRAAKSR 427

Mouse   230 EEEAATAEEGEEETVVSGEEPLG-FLSRMPPGPAGL 264
            :|:.|.:||..:.:...|:...| :.:..|..|..:
  Fly   428 QEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSV 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox12	NP_035568.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		5/21 (24%)
		SOX-TCF_HMG-box	39..110	CDD:238684	38/70 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..287		41/213 (19%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000269\|PubMed:18403418	282..314
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	38/70 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838614
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870