DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox11 and Sox100B

DIOPT Version :9

Sequence 1:NP_033260.4 Gene:Sox11 / 20666 MGIID:98359 Length:395 Species:Mus musculus
Sequence 2:NP_651839.1 Gene:Sox100B / 45039 FlyBaseID:FBgn0024288 Length:529 Species:Drosophila melanogaster


Alignment Length:361 Identity:104/361 - (28%)
Similarity:146/361 - (40%) Gaps:82/361 - (22%)


- Green bases have known domain annotations that are detailed below.


Mouse    48 HIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMAD 112
            ||||||||||||::..||.:.:|.|.:.|:|:||.|||.||.||||:|.||:..||:||:.|..:
  Fly    76 HIKRPMNAFMVWAQAARRVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQE 140

Mouse   113 YPDYKYRP-RKKPKTDPAAKPSAGQSPDKSAAGAKAAKGPGKKCAKLKAPAGKAGAGKAAQP-GD 175
            :|||||:| |||.:..|:.:...|.||......:......||..:.......:||.|.||.. |.
  Fly   141 HPDYKYQPRRKKARVLPSQQSGEGGSPGPEMTLSATMGSSGKPRSSNSNGQRRAGKGNAAADLGS 205

Mouse   176 CAAGKAAKCVFLDDDDEDDDEDDELQLRPKPDA--------DDDDDEP-----AHSHLLPPPTQQ 227
            ||:..:...|..:..|...:|.....|.....|        :...|.|     :.|.|.||.|. 
  Fly   206 CASTISHANVGSNSSDVFSNEAFMKSLNSACAASLMEQSLIETGLDSPCSTASSMSSLTPPATP- 269

Mouse   228 QPPQLLRRYSVAKVPASPTLSSAAESP------------EGASLYDEVRAGGRLYYSFKNITKQQ 280
                    |:||   .|...:|||.:|            .....|..:...||.|.:...:..|.
  Fly   270 --------YNVA---PSNAKASAANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQG 323

Mouse   281 PPPAPPALSPASSRCVSTSSSSGSSSGSGAEDADDLMFDLSLNF-----------------SQGA 328
            .               |....||:..|...::.|   |..::|.                 :.|.
  Fly   324 Q---------------SAGVQSGAEGGGAGQEMD---FLENINGYGGYTGSRVSYPAYSYPANGG 370

Mouse   329 HSACE-----QPLGAGAAGNLSLSLVD---KDLDSF 356
            |.|.|     |.|.|..|.|...:..|   |::|.:
  Fly   371 HFATEEQQQQQALQASEALNYKPAAADIDPKEIDQY 406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox11NP_033260.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
SOX-TCF_HMG-box 48..119 CDD:238684 41/70 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..258 43/170 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 276..312 5/35 (14%)
Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000269|PubMed:18403418 363..395
Sox100BNP_651839.1 SOX-TCF_HMG-box 76..146 CDD:238684 40/69 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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