DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox10 and Sox100B

DIOPT Version :9

Sequence 1:NP_035567.1 Gene:Sox10 / 20665 MGIID:98358 Length:466 Species:Mus musculus
Sequence 2:NP_651839.1 Gene:Sox100B / 45039 FlyBaseID:FBgn0024288 Length:529 Species:Drosophila melanogaster


Alignment Length:492 Identity:154/492 - (31%)
Similarity:203/492 - (41%) Gaps:124/492 - (25%)


- Green bases have known domain annotations that are detailed below.


Mouse    55 KKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKPHVKRPMNAFMVWAQAAR 119
            |.:.|.|..:|::    |..||.:||.||||.||....:. ...:.|.|:|||||||||||||||
  Fly    33 KAQGQGGRKEDER----ITTAVMKVLEGYDWNLVQASAKA-PTDRKKEHIKRPMNAFMVWAQAAR 92

Mouse   120 RKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKN---G 181
            |.::.|||||.|:||||:|||||:.|.:|||:||:|.||:|||.||::||||||||||:|.   .
  Fly    93 RVMSKQYPHLQNSELSKSLGKLWKNLKDSDKKPFMEFAEKLRMTHKQEHPDYKYQPRRKKARVLP 157

Mouse   182 KAAQGEAECPGGE-----------------------AEQGGAAA--------------------- 202
            ....||...||.|                       |.:|.|||                     
  Fly   158 SQQSGEGGSPGPEMTLSATMGSSGKPRSSNSNGQRRAGKGNAAADLGSCASTISHANVGSNSSDV 222

Mouse   203 --IQAHYKSAH-------LDHRHPEEG--SPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKADP 256
              .:|..||.:       ::....|.|  ||.|       :..|....|||.||.....|.....
  Fly   223 FSNEAFMKSLNSACAASLMEQSLIETGLDSPCS-------TASSMSSLTPPATPYNVAPSNAKAS 280

Mouse   257 KRDGRSL------------GEGGKPHIDFGN--VDIGEISHE-----VMSNMETFDV-TELDQYL 301
            ..:..||            |:|....::.|.  |.|||::::     |.|..|.... .|:|...
  Fly   281 AANNPSLLLRQLSEPVANAGDGYGVLLEAGREYVAIGEVNYQGQSAGVQSGAEGGGAGQEMDFLE 345

Mouse   302 PPNGHPGHVG---SYSAAGYGLGSALAVASGHSAWISKPPGVALPT------------VSPPGVD 351
            ..||:.|:.|   ||.|..|      ....||.|...:....||..            :.|..:|
  Fly   346 NINGYGGYTGSRVSYPAYSY------PANGGHFATEEQQQQQALQASEALNYKPAAADIDPKEID 404

Mouse   352 AKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPYYGHAG 416
            .....:.........||:| .|....:.:   |.|...||  |:|......|..||...||.|.|
  Fly   405 QYFMDQMLPMTQHHHPHHT-HPLHHPLHH---SPPLNSSA--SLSSACSSASSQQPVAEYYEHLG 463

Mouse   417 QASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPT 453
            .:....||      ||.|.: ....|..:|..|.:||
  Fly   464 YSPAASSA------SQNPNF-GPQQPYANGAASMTPT 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox10NP_035567.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..67 4/11 (36%)
Sox_N 12..93 CDD:403592 15/37 (41%)
Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P56693 62..102 12/39 (31%)
SOX-TCF_HMG-box 103..173 CDD:238684 50/69 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..200 23/65 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..275 16/75 (21%)
Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P56693 228..310 24/101 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..375 6/42 (14%)
Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P56693 353..466 27/101 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 433..466 6/21 (29%)
Sox100BNP_651839.1 SOX-TCF_HMG-box 76..146 CDD:238684 50/69 (72%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 115 1.000 Domainoid score I5999
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 150 1.000 Inparanoid score I4360
Isobase 1 0.950 - 0 Normalized mean entropy S11712
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 1 1.000 - - otm42976
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45803
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5318
SonicParanoid 1 1.000 - - X1210
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.940

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