DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sorl1 and yl

DIOPT Version :9

Sequence 1:NP_035566.2 Gene:Sorl1 / 20660 MGIID:1202296 Length:2215 Species:Mus musculus
Sequence 2:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster


Alignment Length:1215 Identity:314/1215 - (25%)
Similarity:461/1215 - (37%) Gaps:404/1215 - (33%)


- Green bases have known domain annotations that are detailed below.


Mouse   636 SDERGNECL------LGHKTVFKRRT---------PHATCFNGEDFDRPVVVSNCSCTREDYECD 685
            |||||  ||      .|......|.|         .|:.|.:|.| :..:..|...|..:  :|.
  Fly   257 SDERG--CLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSD-ETDLCHSKPDCDAK--KCA 316

Mouse   686 FGFKMSEDLSLEVCVPDPEFSGKPYSPPVPCPVGSSYRRTRGYR--------------KISGDTC 736
            .|.|         |...|....:.:     ||        :|:|              |...|.|
  Fly   317 LGAK---------CHMMPASGAECF-----CP--------KGFRLAKFEDKCEDVDECKEQDDLC 359

Mouse   737 SGG------------DVEARLEGELVPCPLA-----EENEFILYAMRKSI------------YRY 772
            |.|            |....|:.:...|...     |:...:||..:.:|            :.|
  Fly   360 SQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVY 424

Mouse   773 DLASGATEQLPLSGLRAAVALDFDYERNCLYWSDLALDTIQRLCLNG-STGQEVIINSGLETVEA 836
            .:|...::.:.::           |:.:.:||:::..:....:..|| .:..|:::.|||:..|.
  Fly   425 QVAGNLSKVIGVA-----------YDGSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPED 478

Mouse   837 LAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVL-----DRPRALVLVPQEGVMFWTDWG 896
            ||.:.|:|.:|:.|...:.|.|.:.||      :|.:||     .:||:|.:.||:|:|||||||
  Fly   479 LAVDWLTQNIYFSDNIMRHIAVCSNDG------LNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWG 537

Mouse   897 DLKPGIYRSYMDGSAAYRLVSEDVKWPNGISVD--SQWIYWTDAYLDCIERITFSGQQRSVILDS 959
            : ||.|.|:.||||.:..:||::::|||||::|  .|.|||.||.|..::.:...|..|..:||.
  Fly   538 E-KPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDG 601

Mouse   960 -LPHPYAIAVFKNEIYWDDWSQLSIFRASKHSRSQVEILASQLTGLMDMKVFYKGKNAGS-NACV 1022
             |.|||.:|:|::::||.||:..|:....|.|.....|||...| :..:.:::..|...| :.|.
  Fly   602 MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRT-IYAVHIYHPAKQPNSPHGCE 665

Mouse  1023 PQPCSLLCL---PKANNSKSCRCPEGVASSVLPSGDLMCDCPQGYQR----KNNTCVKEENT--- 1077
            ...||.|||   |:. ...||.||:|:.   |......|...:..||    .....::.|:|   
  Fly   666 NATCSHLCLLAEPEI-GGHSCACPDGMR---LAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFG 726

Mouse  1078 -----------CLRNQ--YRCSNGNCINSIWWCDFDND---------------------CGDMS- 1107
                       ||.|:  |...||:.|.:      |||                     .|::| 
  Fly   727 RHQVSKSYTLPCLINEMVYNRINGSLIIA------DNDQRLILEFQPESHESNVLVRSNLGNVSA 785

Mouse  1108 -------------DERNCPTTVCDADTQFRC-------QE----------SGTC----------- 1131
                         |.......|....|:.|.       ||          .|..           
  Fly   786 LAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSH 850

Mouse  1132 ---IPLSYKCD----LEDDCGDN---------------SDES------------HC--------- 1153
               ||||.|.:    .|||.||:               ||..            |.         
  Fly   851 IDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRR 915

Mouse  1154 ----------------------------------------------------------------- 1153
                                                                             
  Fly   916 PYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSP 980

Mouse  1154 ---EMHQCRSDEFNCSSGMCI-----RSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCHNGH 1210
               |.|.|:.....||. :|:     .|..:|......||..:.....|:  .||   |:||:|.
  Fly   981 VGQESHPCQQQNGGCSH-ICVGEGPYHSICLCPAGFVYRDAGNRTCVEAL--DCE---FRCHSGE 1039

Mouse  1211 CIPQRWACDGDADCQDGSDEDPVSCEKK--------C--NGFHCPNG-TCIPSSKHCDGLRDCPD 1264
            |:.....|:|..||.|.|||  ::|:::        |  |.|.|.:| .|:...:.||..:||.|
  Fly  1040 CLTMNHRCNGRRDCVDNSDE--MNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHD 1102

Mouse  1265 GSDEQHCEPF-----CTRFMDFVCKNRQQCLFHSMVCDGIVQCRDGSDEDAAFAGCSQDPEFHKE 1324
            .|||||||.|     | ......|.| .:|:..|:||||...|.|.|||...        |....
  Fly  1103 HSDEQHCEKFDKSKKC-HVHQHGCDN-GKCVDSSLVCDGTNDCGDNSDELLC--------EATSR 1157

Mouse  1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEAN-CENPTEAPNCSRYFQFHCENGHCIPNRWKC 1388
            |:...|||.:|.||:..|:|||..||.|.|||.: |.:.:..|:..|     |..|.|:.....|
  Fly  1158 CEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQR-----CLLGQCLDRSLVC 1217

Mouse  1389 DRENDCGDWSDEKDCG-DSHVLPSPTPGPSTCLPNYFHCSSG--ACVMGTWVCDGYRDCADGSDE 1450
            |..|||||.|||.:|| ||..:      ..:|..:.:.|:|.  .|:..|..|:|..:|..|.||
  Fly  1218 DGHNDCGDKSDELNCGTDSSTM------NISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDE 1276

Mouse  1451 EACPSLANSTAASTPTQFGQCDRFEFECHQPKKCIPNWKRCDGHQDCQDGQDEANCP-------- 1507
            ..|..:              |..:||:|...::||....||||.:||.||.||.:|.        
  Fly  1277 ADCGDV--------------CSIYEFKCRSGRECIRREFRCDGQKDCGDGSDELSCELEKGHHNQ 1327

Mouse  1508 ------THSTLTCTSREFKCEDGEACIVLSERCDGFLDCSDESDE 1546
                  :.|:.:|....|.|:||| |:.||..|:.|.||::..||
  Fly  1328 SQIQPWSTSSRSCRPHLFDCQDGE-CVDLSRVCNNFPDCTNGHDE 1371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sorl1NP_035566.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 59..84
VPS10 124..753 CDD:214740 32/157 (20%)
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452
BNR 4 521..532
BNR 5 562..573
Sortilin_C 588..753 CDD:292523 32/157 (20%)
LY 780..821 CDD:214531 5/41 (12%)
LDL-receptor class B 1 800..843 11/43 (26%)
LY 824..866 CDD:214531 15/41 (37%)
LDL-receptor class B 2 844..887 14/47 (30%)
LY 868..910 CDD:214531 22/46 (48%)
LDL-receptor class B 3 888..932 24/45 (53%)
Ldl_recept_b 890..929 CDD:278487 22/38 (58%)
LY 913..953 CDD:214531 16/41 (39%)
LDL-receptor class B 4 933..972 16/39 (41%)
LDL-receptor class B 5 973..1013 11/39 (28%)
LDLa 1078..1112 CDD:238060 13/70 (19%)
LDLa 1117..1153 CDD:238060 17/97 (18%)
Ldl_recept_a 1157..1192 CDD:278486 8/39 (21%)
Ldl_recept_a 1198..1230 CDD:278486 13/31 (42%)
LDLa 1240..1271 CDD:238060 14/31 (45%)
LDLa 1281..1308 CDD:197566 11/26 (42%)
LDLa 1325..1359 CDD:238060 17/34 (50%)
LDLa 1373..1403 CDD:238060 13/29 (45%)
LDLa 1419..1453 CDD:238060 11/35 (31%)
LDLa 1471..1506 CDD:238060 16/34 (47%)
LDLa 1514..1549 CDD:238060 15/33 (45%)
FN3 1557..1630 CDD:238020
FN3 1651..1742 CDD:238020
FN3 1752..1831 CDD:238020
FN3 1935..2022 CDD:238020
FN3 2026..2113 CDD:238020
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250|UniProtKB:Q92673 2162..2165
Endocytosis signal. /evidence=ECO:0000255 2173..2178
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250|UniProtKB:Q92673 2191..2215
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250|UniProtKB:Q92673 2202..2215
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250|UniProtKB:Q92673 2209..2213
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060 5/6 (83%)
LDLa 271..302 CDD:238060 7/31 (23%)
FXa_inhibition 352..387 CDD:291342 7/34 (21%)
Ldl_recept_b 442..482 CDD:278487 11/39 (28%)
LY 466..508 CDD:214531 15/47 (32%)
Ldl_recept_b 529..569 CDD:278487 23/40 (58%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 15/40 (38%)
FXa_inhibition 669..700 CDD:291342 12/34 (35%)
LY 774..815 CDD:214531 5/40 (13%)
LDLa 1032..1062 CDD:238060 14/34 (41%)
LDLa 1074..1109 CDD:238060 15/34 (44%)
LDLa 1118..1152 CDD:238060 14/35 (40%)
LDLa 1157..1189 CDD:197566 15/31 (48%)
LDLa 1198..1232 CDD:238060 15/38 (39%)
LDLa 1243..1279 CDD:238060 11/35 (31%)
LDLa 1283..1318 CDD:238060 16/34 (47%)
LDLa 1340..1371 CDD:197566 13/31 (42%)
FXa_inhibition 1388..1416 CDD:291342
EGF_CA 1418..1452 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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