Protein Alignment ERBB4 and erbb4b

DIOPT Version :10

• Sequence 1: XP_016859066.1
• Gene: ERBB4 / 2066
• HGNCID: 3432
• Length: 1349
• Species: Homo sapiens
• Sequence 2: XP_068079769.2
• Gene: erbb4b / 569836
• ZFINID: ZDB-GENE-030918-5
• Length: 1408
• Species: Danio rerio
• Alignment Length: 1478
• Identity: 1009/1478 - (68%)
• Similarity: 1134/1478 - (76%)
• Gaps: 199/1478 - (13%)

Human     1 MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEI 65
            ||.|:.| ..:..|:.:..|:.||||.||.|||||||:||||:||||.|||||||||||||||||
Zfish     1 MKLASSL-CCLGFLLTSVAVRLSDSQQVCTGTENKLSTLSDLDQQYRTLRKYYENCEVVMGNLEI 64

Human    66 TSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFG 130
            |||:.:||||||||:||||||||||||||.|||||||||||||:|||||||||||||||:|||||
Zfish    65 TSIDRSRDLSFLRSIREVTGYVLVALNQFEYLPLENLRIIRGTRLYEDRYALAIFLNYRRDGNFG 129

Human   131 LQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCLAHQDTEKN 195
            |::|||||||||||||||||||||||:||||||||||:|..|.:| :|.:|.||.|
Zfish   130 LRQLGLKNLTEILNGGVYVDQNKFLCHADTIHWQDIVKNARPDHL-VVPSNSSSSC--------- 184

Human   196 NPQLLQSLQPFSLITPGGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHREC 260
                             .|||::|.||||||.|:.||:||:|||||||||||:|||||||||.||
Zfish   185 -----------------QRCHRACNGRCWGPKEDQCQSLTKTVCAEQCDGRCFGPYVSDCCHPEC 232

Human   261 AGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV 325
            ||||||||:||||||.|||||||||||||:.|||||||||||||..|||||||||||||||||||
Zfish   233 AGGCSGPKNTDCFACTNFNDSGACVTQCPRPFVYNPTTFQLEHNPWAKYTYGAFCVKKCPHNFVV 297

Human   326 DSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKING 390
            |.|||||||||:|||||||.||||.|||||||||||||||.||.:||||||||||:|||||||||
Zfish   298 DHSSCVRACPSNKMEVEENRIKMCIPCTDICPKACDGIGTASLQTAQTVDSSNIDRFINCTKING 362

Human   391 NLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLY 455
            ||:||:|||.||.|:.||.:||||||||||||||||||||||||.||||.||||||.|||||.||
Zfish   363 NLVFLITGIKGDVYHNIEPLDPEKLNVFRTVREITGFLNIQSWPENMTDLSVFSNLATIGGRALY 427

Human   456 SGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAE 520
            ||:|||:||||.|||:|.|||:||||||:|:|:||.||||:|:|||.||....|:.:||:||..:
Zfish   428 SGISLLVLKQQWITSMQLQSLREISAGNVYVTNNSQLCYYNTVNWTRLFRINTQKALIRNNRDPK 492

Human   521 NCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDG------------------ 567
            .|..:.|||:.|||..||||||||||||||.|.|||.|:|||||::|
Zfish   493 ECILDRMVCDPLCSDAGCWGPGPDQCLSCRFFIRGRTCVESCNLHEGPAGSKPKLLTRPYVVEKR 557

Human   568 ------EFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA 626
                  :.|||.|||:|:|||.|||..||..|||.|||||:|.||.|||||||||||||||||||
Zfish   558 EAGLERDVREFANGSVCLECDAQCEVPEDDALTCTGPGPDHCVKCRHFKDGPNCVEKCPDGLQGA 622

Human   627 NSFIFKYADPDRECHPCHPNCTQGCIGSSIEDCIGLMDRCNGPTSHDCIYYPWTGHSTLPQHART 691
            :|||||||:.:.||||||.||||||.|..::||||:||                         ||
Zfish   623 SSFIFKYAEANNECHPCHVNCTQGCTGPRLQDCIGVMD-------------------------RT 662

Human   692 PLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKE 756
            ||||||||||||:::|:||:.|:.||||||||||||||||||||||||||||.||||||||||||
Zfish   663 PLIAAGVIGGLFVVIIIGLSVAISVRRKSIKKKRALRRFLETELVEPLTPSGAAPNQAQLRILKE 727

Human   757 TELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHL 821
            |||||||:||:|||||||||||||||||||||||||||||.|||||||||||||||||||:||||
Zfish   728 TELKRVKILGAGAFGTVYKGIWVPEGETVKIPVAIKILNEATGPKANVEFMDEALIMASMEHPHL 792

Human   822 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLA 886
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
Zfish   793 VRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLA 857

Human   887 ARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGK----------MPIKWMALECIHYRKFTHQ 941
            |||||||||||:|||||||||||:.:||||||||||          |||||||||||||||||||
Zfish   858 ARNVLVKSPNHIKITDFGLARLLDANEKEYNADGGKLLKYCLLLCQMPIKWMALECIHYRKFTHQ 922

Human   942 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRP 1006
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   923 SDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRP 987

Human  1007 KFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNI 1071
            :|||||||||||||||||||||||||||||||||||||||:|||||:|||:|||||||||||::|
Zfish   988 RFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQSLLDEEELEDLMDAEEYLVPQAYSI 1052

Human  1072 PPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAE-------QGVSVPYRAP-TST 1128
            ||..||:|:|:|.||                |||.|:||.|..|       :.|:|...:| .||
Zfish  1053 PPLAYTTRSRMDPNR----------------NQFAYQDGSFGMEDMMATIPRVVAVSAVSPGCST 1101

Human  1129 IPEAPVAQGA--TAEIFDDSCCNGTLRKPVAPHVQ--EDSSTQRYSADPTVFAPERSPRGELDEE 1189
            ..::...|||  ::|.|:||.|||||||..:|...  :|||.|||||||||...|...|.|.|::
Zfish  1102 QKQSKGQQGASGSSEAFEDSRCNGTLRKKASPRASTGDDSSGQRYSADPTVILCEHGARAETDQD 1166

Human  1190 GYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLNTFA 1254
            |||:.|:||...::||||||||||:.|:||::..|:. .||:.|||.||.||||||:|||||||.
Zfish  1167 GYMSAMQDKKPSDFLNPVEENPFVTHRRNGEVHTLER-GYHSTSNGQPKLEDEYVNDPLYLNTFH 1230

Human  1255 NTLGKA-EYLKNN----------------------------------------ILSMP------- 1271
            ||..|: :.|:.|                                        |.:.|
Zfish  1231 NTGEKSHDALRKNGVPVVHTAAAAAATVAAANTITANNHTLSQTMQPAASSAHITTQPLYQGKPS 1295

Human  1272 -----------------------------------EKAKKAFDNPDYWNHSLPPRSTLQHPDYLQ 1301
                                               .||||.||:|:||.|||||::||.:|:|||
Zfish  1296 ISTLSGHTLHSAHPGHALHPTHTLHPAHTGTIKADLKAKKTFDSPEYWQHSLPPKATLHNPEYLQ 1360

Human  1302 EYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1349
            :.||::||:|||||||.||||.||||:::|||||||||||||.|||||
Zfish  1361 DCSTRFFYRQNGRIRPAVAENQEYLSDYALKPGTVLPPPPYRQRNTVV 1408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERBB4	XP_016859066.1	Recep_L_domain	55..167	CDD:460032	101/111 (91%)
		Furin-like	215..358	CDD:395614	122/142 (86%)
		Recep_L_domain	384..504	CDD:460032	94/119 (79%)
		GF_recep_IV	528..660	CDD:464344	96/155 (62%)
		TM_ErbB4	683..726	CDD:213053	27/42 (64%)
		PTKc_HER4	751..1053	CDD:173655	290/311 (93%)
erbb4b	XP_068079769.2	None