DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERBB4 and Egfr

DIOPT Version :9

Sequence 1:	XP_016859066.1	Gene:	ERBB4 / 2066	HGNCID:	3432	Length:	1349	Species:	Homo sapiens
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1429	Identity:	506/1429 - (35%)
Similarity:	695/1429 - (48%)	Gaps:	356/1429 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    28 VCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSI-EHNRDLSFLRSVREVTGYVLVAL 91
            :|.||:::||..|:.|..||.||..|.||..|.||||:|.: ..|.|||||.::||||||:|::.
  Fly   101 ICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISH 165

Human    92 NQFRYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQ 151
            ...:.:....|:||||..|:     |::|||  |:.|.|     :..|.:.:|.::|||.|....
  Fly   166 VDVKKVVFPKLQIIRGRTLFSLSVEEEKYAL--FVTYSK-----MYTLEIPDLRDVLNGQVGFHN 223

Human   152 NKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCLAHQDT--EKNNPQLLQSLQPFSLITPGGR 214
            |..||:..||.|.:||            :||:.....:..|  |:..|                :
  Fly   224 NYNLCHMRTIQWSEIV------------SNGTDAYYNYDFTAPERECP----------------K 260

Human   215 CHKSCTGRCWGPTENHCQTLTRTVCAEQC-DGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNF 278
            ||:|||..|||....:||..::..|:.|| .||||||...:|||..|||||:||...||.||.||
  Fly   261 CHESCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNF 325

Human   279 NDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEE 343
            .|.|.|..:||....|||||:.||.|...||.|||.|||:||.:.:.|:.:|||:||..||  ::
  Fly   326 FDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM--DK 388

Human   344 NGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHG--DPYNA 406
            .|  .|.||...|||.|.|:        ..:.:.|||.|.|||.|:||:..|.....|  |.|..
  Fly   389 GG--ECVPCNGPCPKTCPGV--------TVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYAN 443

Human   407 IE------AIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGL-SLLILK 464
            ..      .:|||:|.||.||:||||:|||:...|...:.|.|.||.||.||.|...: :.|.:.
  Fly   444 YTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIV 508

Human   465 QQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVC 529
            :..:.||:.::||:||:|::.|..|.:|||...|.|..:.....|::.:.:|.:|:.|...|.:|
  Fly   509 KSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTIC 573

Human   530 NHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLT 594
            :..|:.|||||.|.||||:|:.|:....||..|......:: |:|.: |..|.|:|.       |
  Fly   574 SDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYK-FDNRT-CKICHPECR-------T 629

Human   595 CHGPGPDNCTKCSHFKDGPNCVEKCP-----------------DGLQG----------------- 625
            |:|.|.|:|.:|.|.:||.:||.:||                 ||..|
  Fly   630 CNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAI 694

Human   626 -----------------ANSFIFKYADPD--------------RECHP----------------- 642
                             .:.:.::|..|.              |:|||
  Fly   695 INNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSK 759

Human   643 -----------------------------CHPNCTQGCIGSSIEDC-----IGLMD-RCNGP--- 669
                                         |||.| .||.|...:||     ..|.| ...||
  Fly   760 CTHYKRREQCETECPADHYTDEEQRECFQCHPEC-NGCTGPGADDCKSCRNFKLFDANETGPYVN 823

Human   670 -TSHDC----------IYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYV------- 716
             |..:|          :.|.:|...  |..|.:|..::.:...|.:.:|..:|.||.|
  Fly   824 STMFNCTSKCPLEMRHVNYQYTAIG--PYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILC 886

Human   717 ------RRKSIKKKRALRRFLE---TELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGT 772
                  |:|...||..::..:.   .|..|||.||....|..:|||:|:.||::..|||.||||.
  Fly   887 VVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGR 951

Human   773 VYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVT 837
            ||||:||||||.||||||||.|.::||.:::.||:.||.||||::|.:|::||.||:|..:.|:|
  Fly   952 VYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLIT 1016

Human   838 QLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITD 902
            ||||.||||:||..::|.|||:.||||..||||||.||||:||||||||||||||::|:.|||||
  Fly  1017 QLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITD 1081

Human   903 FGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPT 967
            ||||:||..|..||.|.||||||||:|||||..|.||.:||||::|||||||:|||.:|::.||.
  Fly  1082 FGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPA 1146

Human   968 REIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDD 1032
            ::||||:|.|.:|.||.||::|:|..::.||.:||..||.||:|...|:..||||.|||.|.||.
  Fly  1147 KDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDK 1211

Human  1033 RMKLPSPNDSKFFQNLLDEEDL-----------EDMMDAEEYLVPQAFNIPPPIYTSRARIDSNR 1086
            ..:||:....       ||:||           |.:.:.::||.|:|  .|.|         |:|
  Fly  1212 FTRLPAYTSQ-------DEKDLIRKLAPTTDGSEAIAEPDDYLQPKA--APGP---------SHR 1258

Human  1087 SEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGT 1151
            ::.                                    |..||:
  Fly  1259 TDC------------------------------------TDEIPK-------------------- 1267

Human  1152 LRKPVAPHVQEDSSTQRYSADPTVFAPERSPRG--ELD----EEGYMTPMRDKP--KQEYLNPVE 1208
                          ..||..||   :.:.|..|  |.|    |.|......|.|  :.:||.|..
  Fly  1268 --------------LNRYCKDP---SNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLMPTC 1315

Human  1209 ENPFVSRRKNGDLQALDNPEYHNASN-----------GPPKAEDEYVNEPLYLNTFANTLGKAE 1261
            : |..:...|     ::||..:|.:.           |.|.:    |:.|.||.. |.|||..|
  Fly  1316 Q-PGPNNNNN-----INNPNQNNMAAVGVAAGYMDLIGVPVS----VDNPEYLLN-AQTLGVGE 1368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERBB4	XP_016859066.1	None
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	50/127 (39%)
		GF_recep_IV	572..684	CDD:291509	40/120 (33%)
		FU	573..>606	CDD:238021	16/32 (50%)
		FU	617..659	CDD:214589	19/49 (39%)
		FU	662..716	CDD:214589	3/53 (6%)
		FU	739..786	CDD:238021	3/46 (7%)
		FU	784..834	CDD:214589	15/50 (30%)
		PTKc_EGFR_like	930..1208	CDD:270648	172/277 (62%)
		STYKc	938..1194	CDD:214568	159/255 (62%)
		Recep_L_domain	128..239	CDD:279382	46/117 (39%)
		Furin-like	253..401	CDD:279142	73/167 (44%)
		FU	255..292	CDD:214589	15/52 (29%)
		FU	302..345	CDD:238021	24/42 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	339	1.000	Domainoid score	I1096
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I933
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm40594
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5222
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870