Protein Alignment ERBB4 and let-23

DIOPT Version :10

• Sequence 1: XP_016859066.1
• Gene: ERBB4 / 2066
• HGNCID: 3432
• Length: 1349
• Species: Homo sapiens
• Sequence 2: NP_001300607.1
• Gene: let-23 / 174462
• WormBaseID: WBGene00002299
• Length: 1335
• Species: Caenorhabditis elegans
• Alignment Length: 1482
• Identity: 400/1482 - (26%)
• Similarity: 608/1482 - (41%)
• Gaps: 413/1482 - (27%)

Human    27 SVCAGTENKLSS------LSDLEQQYRALRKYYENCEVVMGNLEITSIEHN-------------- 71
            |||:||.|.:|.      |.|||..||..|:.|       ||||||.||.|
 Worm    50 SVCSGTTNGISRYGTGNILEDLETMYRGCRRVY-------GNLEITWIEANEIKKWRESTNSTVD 107

Human    72 --------RDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN 128
                    :.::|..::.|:.|.:::.....:.:....||:|.|.:::.|. ||.|..|.:
 Worm   108 PKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVFHDN-ALYIHKNDK---- 167

Human   129 FGLQELGLKNLTEILNGGVYVDQNKFLCY-ADTIHWQDIVRNPWPSNLTLVSTNGSSGCLAHQDT 192
              :.|:.::.|..|.||.|.:..|..:|| .|.|.|::::.:|   ::..|.|..|     ||..
 Worm   168 --VHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDP---DVQKVETTNS-----HQHC 222

Human   193 EKNNPQLLQSLQPFSLITPGGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVS--DC 255
            .:|...:             .:||:||..:|||..:|.||.:.|:||.:.|....|....|  :|
 Worm   223 YQNGKSM-------------AKCHESCNDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYEC 274

Human   256 CHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCP 320
            |...|.|||:|....:|.||..:...|.|:..||...::|..|.:|..|.:.:|..|..|||:||
 Worm   275 CDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECP 339

Human   321 HNFVVDSSSCVRACPSSKMEVEENGIKMCKPC-TDICPKACDGIGTGSLMSAQTVD----SSNID 380
            ...::::..|||.|...........::.|:.| :..|||.|            |||    :..:.
 Worm   340 PELLIENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKIC------------TVDGHLTNETLK 392

Human   381 KFINCTKINGNLIFLVTGIHGDPYNAIE-AIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFS 444
            ....|.:|:|:||             || |...|:|.|..||:.::.::.|..  .|..|.....
 Worm   393 NLEGCEQIDGHLI-------------IEHAFTYEQLKVLETVKIVSEYITIVQ--QNFYDLKFLK 442

Human   445 NLVTIGGRVLYS-GLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTIN 508
            ||..|.||.|:: ..:|.|.:...:..|...|||.|..|.:.|..|..|||...|:|:::.::..
 Worm   443 NLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKG 507

Human   509 Q----RIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEF 569
            :    .:.|.:||.::.|..|..||:..|:..||||..|:.||.|:.:.....|:|.|:...  |
 Worm   508 KDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKG--F 570

Human   570 REFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSH-------FKDGPNCVEKCPDGLQGAN 627
            ...:....|..|.|:||       ||:|.|..:|..|.|       |.:...||..||
 Worm   571 LRNQTSMKCERCSPECE-------TCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCP------- 621

Human   628 SFIFKYADPDRECHPCHPNC--------------------------------------------- 647
              :..:......|..|||.|
 Worm   622 --VSHFPTQKNVCEKCHPTCYDNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVE 684

Human   648 ------------TQGCIGSSIEDC---------IG-----------------------LMDRCNG 668
                        |:|.|.:..|.|         .|                       .||:|
 Worm   685 NDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQC-- 747

Human   669 PTS----------------HDC--IYYPWTGHST-------------------------LP---- 686
            |.:                |:|  .|:...|.||                         ||
 Worm   748 PVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQCVSECPKNLPFSNP 812

Human   687 ------------QHARTPLIAAG-VIGG-----LFILVIVGLTFAVYVRRKSIKKKRALRRFLET 733
                        :..:|.::..| |:.|     ||||:       ||.|.:.|.||..:...::.
 Worm   813 ANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILL-------VYWRCQRIGKKLKIAEMVDM 870

Human   734 ELVEPLTPSGTAPNQAQLRILKETEL--KRVKVLGSGAFGTVYKGIWVPE-GETVKIPVAIKILN 795
            ..:.|:..| ..||.:::.::..:||  |..|.||:||||||:.||:.|: .:.||||||||:..
 Worm   871 PELTPIDAS-VRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQ 934

Human   796 ETTGPKANVEFMDEALIMASMDHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLEYVHEHKDNIGSQ 859
              |......|.::||..|..:.|.:|::::|.|: ...:::||...|.|.|..::..||:|:|::
 Worm   935 --TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAR 997

Human   860 LLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMP 924
            ..:.:|.|||.||.|||::|:||||||.||||||..|||:||||||:::|:.|........||:.
 Worm   998 EQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVA 1062

Human   925 IKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTID 989
            |||:|:|......:||.||||::|||.||::|||..||.|:.|..|.:.|:.|.||.|||.|:.|
 Worm  1063 IKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQD 1127

Human   990 VYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEED- 1053
            :|..:::|||.|..|||.|:.|...|....:.||.:|            .|.:|..::.|..|:
 Worm  1128 LYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFL------------ENSNKISESDLSAEER 1180

Human  1054 -----LEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFA 1113
                 :.:|.|.         ||.|.:|..:          |..|....:|.|...|....|...
 Worm  1181 FQTERIREMFDG---------NIDPQMYFDQ----------GSLPSMPSSPTSMATFTIPHGDLM 1226

Human  1114 AE-QGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFA 1177
            .. |.|:      :|.....|...|:||                    |||:|   |....|
 Worm  1227 NRMQSVN------SSRYKTEPFDYGSTA--------------------QEDNS---YLIPKT--- 1259

Human  1178 PERSPRGELDEEGYM-TPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAED 1241
                  .|:.:...: |.:.::..|..|:|          .|||        |:|..| .|.:..
 Worm  1260 ------KEVQQSAVLYTAVTNEDGQTELSP----------SNGD--------YYNQPN-TPSSSS 1299

Human  1242 EYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRST 1293
            .|.|||              :||.   ..||.:::| :...|.|..:..:.|
 Worm  1300 GYYNEP--------------HLKT---KKPETSEEA-EAVQYENEEVSQKET 1333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERBB4	XP_016859066.1	Recep_L_domain	55..167	CDD:460032	33/134 (25%)
		Furin-like	215..358	CDD:395614	48/145 (33%)
		Recep_L_domain	384..504	CDD:460032	37/121 (31%)
		GF_recep_IV	528..660	CDD:464344	42/204 (21%)
		TM_ErbB4	683..726	CDD:213053	18/89 (20%)
		PTKc_HER4	751..1053	CDD:173655	126/305 (41%)
let-23	NP_001300607.1	Recep_L_domain	77..205	CDD:460032	35/141 (25%)
		Furin-like	229..378	CDD:395614	48/161 (30%)
		Recep_L_domain	396..503	CDD:460032	37/121 (31%)
		GF_recep_IV	531..652	CDD:464344	37/138 (27%)
		FU	702..752	CDD:214589	7/51 (14%)
		FU	759..806	CDD:214589	6/46 (13%)
		PK_Tyr_Ser-Thr	898..1153	CDD:462242	117/256 (46%)