Protein Alignment ERBB4 and erbb4

DIOPT Version :10

• Sequence 1: XP_016859066.1
• Gene: ERBB4 / 2066
• HGNCID: 3432
• Length: 1349
• Species: Homo sapiens
• Sequence 2: XP_031748752.1
• Gene: erbb4 / 100493234
• XenbaseID: XB-GENE-877077
• Length: 1300
• Species: Xenopus tropicalis
• Alignment Length: 1342
• Identity: 1083/1342 - (80%)
• Similarity: 1175/1342 - (87%)
• Gaps: 55/1342 - (4%)

Human     9 VWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRD 73
            ||:|:|.|.||:|.:..|||||||||||||||||||||:||||||||||||||||||||||..|:
 Frog    13 VWLSVLWALGTLQAACGQSVCAGTENKLSSLSDLEQQYKALRKYYENCEVVMGNLEITSIEPGRN 77

Human    74 LSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKN 138
            ||||||:||||||||||||||.||||||||||||.||||||||||||||||||||:||:||||:|
 Frog    78 LSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGIKLYEDRYALAIFLNYRKDGNYGLRELGLRN 142

Human   139 LTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCLAHQDTEKNNPQLLQSL 203
            ||||||||||:.||||||||||||||||||.|   |.|||..:.::.|
 Frog   143 LTEILNGGVYLGQNKFLCYADTIHWQDIVRTP---NATLVPMSSNAEC----------------- 187

Human   204 QPFSLITPGGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPK 268
                     |||.|||.||||||::.|||.||:|||||||||||||.||||||||||||||:|||
 Frog   188 ---------GRCPKSCMGRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSDCCHRECAGGCTGPK 243

Human   269 DTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRA 333
            |||||:||.|||||:|||||||..:||||.||||.|..||||||||||.|||||||||.||||||
 Frog   244 DTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHNFVVDDSSCVRA 308

Human   334 CPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTG 398
            |||:|||||||||||||||..||||.|||||||||.|||||||||||||||||||||||.|||||
 Frog   309 CPSNKMEVEENGIKMCKPCAGICPKVCDGIGTGSLQSAQTVDSSNIDKFINCTKINGNLHFLVTG 373

Human   399 IHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLIL 463
            |.||||:.|.|::|:|||:|.|||||||||||||||.||||.|||||||.|||||||||:|||||
 Frog   374 IDGDPYHNIAALEPQKLNIFFTVREITGFLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLIL 438

Human   464 KQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMV 528
            |||.:.||||||||||||||:|||||.|||||||:|||:||.|.|||..||:|:|.|||||||||
 Frog   439 KQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSNQRTTIRENKKPENCTAEGMV 503

Human   529 CNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLL 593
            |:.|||:.||||||.:||||||.||||:.|:.|||||.||.|||.|||:||.||.|||||||.::
 Frog   504 CDPLCSNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGESREFVNGSVCVMCDSQCEKMEDSIV 568

Human   594 TCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQGCIGSSIED 658
            ||:|||||:|||||:||||||||||||:||||||||||||||.|:||||||||||.||.|..::|
 Frog   569 TCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDGCRGPRLKD 633

Human   659 CIGLMDRCNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKK 723
            |||::|                         |||||||.|||||||:||:.||||||:|||||||
 Frog   634 CIGIID-------------------------RTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKK 673

Human   724 KRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIP 788
            ||||||||||||||||||||||||||||||||||||||:|:||||||||||||||||||||||||
 Frog   674 KRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRIKILGSGAFGTVYKGIWVPEGETVKIP 738

Human   789 VAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHK 853
            |||||||||||||||.|||||||||||||||||||||||.||||||||||||||||||:||||||
 Frog   739 VAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPTIQLVTQLMPHGCLLDYVHEHK 803

Human   854 DNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA 918
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   804 DNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA 868

Human   919 DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 983
            ||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||
 Frog   869 DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 933

Human   984 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNL 1048
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   934 PVCTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNL 998

Human  1049 LDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFA 1113
            ||||||.||||||||||||||||||||||||.|||||||||||||||||||||||||||||||:.
 Frog   999 LDEEDLGDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGYT 1063

Human  1114 AEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTL-RKPVAPHVQEDSSTQRYSADPTVFA 1177
            .::.|::|:|.....|.|...|||||||:|||.|||||| ::.|:..:.|:||.||||||||.|.
 Frog  1064 TQEAVNLPFRPTACPITELSTAQGATAEVFDDVCCNGTLCKQVVSERIPEESSLQRYSADPTAFV 1128

Human  1178 PERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDE 1242
            |||:|||.:.|:||||||::|||.:||||||||||||||||||:||::.|||:|..:...|:|||
 Frog  1129 PERNPRGVVGEDGYMTPMKEKPKSDYLNPVEENPFVSRRKNGDVQAVEKPEYNNGPSTQSKSEDE 1193

Human  1243 YVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKY 1307
            ||.|.||||:||.....|||||||.|::|||:|||||||:|||||||||||:.|||||.||||||
 Frog  1194 YVKERLYLNSFAKPKENAEYLKNNGLTVPEKSKKAFDNPEYWNHSLPPRSTIHHPDYLHEYSTKY 1258

Human  1308 FYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV 1349
            ||||||||||:||||||||:||:|||||||||||||||||||
 Frog  1259 FYKQNGRIRPVVAENPEYLTEFTLKPGTVLPPPPYRHRNTVV 1300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERBB4	XP_016859066.1	Recep_L_domain	55..167	CDD:460032	100/111 (90%)
		Furin-like	215..358	CDD:395614	118/142 (83%)
		Recep_L_domain	384..504	CDD:460032	98/119 (82%)
		GF_recep_IV	528..660	CDD:464344	99/131 (76%)
		TM_ErbB4	683..726	CDD:213053	30/42 (71%)
		PTKc_HER4	751..1053	CDD:173655	294/301 (98%)
erbb4	XP_031748752.1	Recep_L_domain	59..171	CDD:460032	100/111 (90%)
		Furin-like	184..333	CDD:395614	121/174 (70%)
		Recep_L_domain	359..479	CDD:460032	98/119 (82%)
		GF_recep_IV	503..635	CDD:464344	99/131 (76%)
		TM_ErbB4	633..676	CDD:213053	35/67 (52%)
		PTKc_HER4	701..1003	CDD:173655	294/301 (98%)