Protein Alignment ERBB3 and erbb3a

DIOPT Version :10

• Sequence 1: NP_001973.2
• Gene: ERBB3 / 2065
• HGNCID: 3431
• Length: 1342
• Species: Homo sapiens
• Sequence 2: XP_005165758.1
• Gene: erbb3a / 386635
• ZFINID: ZDB-GENE-030916-3
• Length: 1438
• Species: Danio rerio
• Alignment Length: 1470
• Identity: 750/1470 - (51%)
• Similarity: 934/1470 - (63%)
• Gaps: 176/1470 - (11%)

Human     7 LQVLGLLFSL---ARGS------EVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGN 62
            ||::.:..:|   ||..      |||    ||.||.|.|||||.:|.||:.:.::|..|::|:||
Zfish    11 LQMIAMCLALRSPARAQTQEGKPEVG----VCTGTQNLLSVTGSSEVQYKLMKEMYTGCQIVIGN 71

Human    63 LEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNS 127
            |||....||.|.||||.|||||||:|:|:|:|..|||..|||:|||.:|:.|||:.|::||..:.
Zfish    72 LEITQMEHNRDFSFLQSIREVTGYILIAINQFRRLPLEQLRVIRGTSLYEDKFALAVLVNYQKDG 136

Human   128 SHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKG 192
            .:.||:|.||.|||||.|||.|.:|..|.:...|:|:|||::..||::::|||... ||||.|.|
Zfish   137 VYGLRELGLTHLTEILEGGVQIIQNKFLSYAPQINWQDIVKNSGAEVIIQDNGPEV-PCHESCGG 200

Human   193 RCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVP 257
            .|||||::.||.||||:||.|||..|||.:|::|||:||||||:||.||||||||:||:||:||.
Zfish   201 PCWGPGNDTCQILTKTVCALQCNVRCFGRSPSECCHNECAGGCTGPLDTDCFACRNFNNSGSCVS 265

Human   258 RCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEP 322
            :||:..:|||:||::||||:.|||:|.:||:.||.|||||.:|||.:||.|||||||.|:|.||.
Zfish   266 QCPRADIYNKVTFKMEPNPNAKYQFGSMCVSHCPPNFVVDGSSCVSSCPADKMEVDKTGVKRCEK 330

Human   323 CGGLCPKACEGTGSG--SRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLN 385
            |.|||||||.|||:|  || |||||.|||.|:|||||.|:|.||:||:.||.::.|.||||:||.
Zfish   331 CEGLCPKACVGTGTGTASR-QTVDSQNIDSFINCTKIQGSLHFLVTGIKGDSYNNISALDPKKLK 394

Human   386 VFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLY-----NRGFSLLIMKNLNVTSLGFRS 445
            :|.||||||..|:|||||..:.:.||||||.||.||:||     .||:|||:||...:.|||.||
Zfish   395 IFNTVREITDILSIQSWPEELEDLSVFSNLATIQGRTLYRGVSSKRGYSLLVMKIPTLKSLGLRS 459

Human   446 LKEISAGRIYISANRQLCYHHSLNWTKVL-RGP----TEERLDIKHNRPRRDCVAEGKVCDPLCS 505
            ||.||.|.|||:.|.||||||::|||::. .||    .::.||||.|||:..|..||.|||||||
Zfish   460 LKRISDGGIYITGNTQLCYHHTVNWTRLFGSGPRALRRQKSLDIKENRPQEQCKLEGHVCDPLCS 524

Human   506 SGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFA-HEAECFSCHPECQPMEGTATCNGSG 569
            |.|||||||.|||||:|:.|||.||..|||::||.|||| .:.||.:||.||...:...||.|.|
Zfish   525 SEGCWGPGPDQCLSCKNFRRGGTCVPDCNFMSGEQREFAGPKNECMACHQECALQDSGDTCKGPG 589

Human   570 SDTCAQCAHFRDGPHCVSSCPHGVLGAKG-PIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQT 633
            ||.|..|||.:|||:||||||.||.|..| .|||:|:.||:|:|||.|||.||.||...||:..:
Zfish   590 SDECKACAHLQDGPYCVSSCPEGVQGENGLIIYKFPNRQNKCQPCHANCTLGCLGPGQNDCVDSS 654

Human   634 LVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANK 698
            ....|.....:.|:||..:::.|.:...:.||.|...|:.||||||||:.|||.|||:|.||..|
Zfish   655 RSSAGLPVTAIVLSVIFCVLLAFSVFVLSVLYRRSLSIRRKRAMRRYLQSGESFEPLEPGEKGVK 719

Human   699 VLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI 763
            |.|||.:.:||:|:|:||||||||||||:|||||:::||||.||.|:|::|||:||.:||||||:
Zfish   720 VHARILRTSELKKIKLLGSGVFGTVHKGIWIPEGDTVKIPVAIKTIQDRTGRQTFQEITDHMLAM 784

Human   764 GSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH 828
            ||||||:|||:||:|||:|||||||..|.||||||:||.|..|.||.||||.||||||||||||.
Zfish   785 GSLDHAYIVRILGICPGASLQLVTQLSPQGSLLDHIRQRRDNLNPQRLLNWCVQIAKGMYYLEEQ 849

Human   829 GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSD 893
            .||||||||||:||||...||:||:|:||||.||:|:..::|.||||||||||||.|.:||||||
Zfish   850 RMVHRNLAARNILLKSDLIVQIADYGIADLLYPDEKKYFFNEIKTPIKWMALESILFRRYTHQSD 914

Human   894 VWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTF 958
            ||||||||||:|::|||||:.:|..:|||||||||||:||||||||||||||||||||||:||||
Zfish   915 VWSYGVTVWEMMSYGAEPYSAMRPQDVPDLLEKGERLSQPQICTIDVYMVMVKCWMIDENVRPTF 979

Human   959 KELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLA 1023
            ||||||||||||||.||||||.|.....:...|.|    :...|:::     |.:.||.::|.:.
Zfish   980 KELANEFTRMARDPHRYLVIKEEDRAPDSASDETH----QNGTEIDI-----LGVALEDQDDEVL 1035

Human  1024 TTTLGSALSL-PVGTLNRPR--GSQSLLSPS--SGYMPMNQGNLGESCQESAVSGSSERCPRPVS 1083
            ...:.:...: |..:.:|.|  ..:|.|:||  :||:||..| |..|.|....|.|.
Zfish  1036 EDAIDAPRYITPSRSFSRLRIDSHRSSLTPSTTAGYLPMTPG-LESSVQTGWASRSR-------- 1091

Human  1084 LHPMPRGCLASESSEGHVTGS-EAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLS 1147
               :...|..||||||.  |: |.|:.:..|...|..|.|.   |.||||.|||.||..|....|
Zfish  1092 ---LDSACTVSESSEGR--GALELEMNDDFSSVGSLRRVRH---REDSAYMSQRDSLSGPPETTS 1148

Human  1148 PPGLEEEDVNGYVMP---DTHLKGT---PSSREGTLS----SVGLSSVLGTEEEDEDEEYEYMN- 1201
            .....|||.|.||:|   ::..|.|   .||| .|||    |.|.|...........|||||||
Zfish  1149 TGTQGEEDQNEYVLPGFGESPEKETLLFTSSR-STLSQKRLSRGHSGDFLEANRGAGEEYEYMNN 1212

Human  1202 --------------------RRR-----------RHSPPHPPRPSSLE----------------- 1218
                                |.|           .|.|..|.:.||:|
Zfish  1213 QTLSLSHIPGQLKEYNQRAPRNRSASFNPGGMYSNHKPSRPSKRSSIEGSESSGGLSQSSTDQRS 1277

Human  1219 ------------------ELGYEYMDVGSDLSASLGSTQSCPLH-PVPIM-PTAGTTP-----DE 1258
                              |:.|||||:..  :....:.....|| |.|:. |....:|     ||
Zfish  1278 HSDGDFLSSEAEYTDGDLEVEYEYMDIRG--AGGPAANMLLKLHLPRPVSNPPLRRSPEDDDEDE 1340

Human  1259 DYEYMNRQ---------RDGGGPGGDY------AAMGACPASEQ---GYEEMRAFQ---GPGHQA 1302
            ||:|.|.|         :.|||...:|      ||.||..|..|   |.:|.|...   ||....
Zfish  1341 DYQYSNHQPRLRNSLRVQGGGGEAYEYEDMDSLAAGGASGAEYQNLDGEDEERDEDWSGGPRSPG 1405

Human  1303 PHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT 1342
            |:|..       ......:|||||||||||.|.|..|.||
Zfish  1406 PYVQV-------HAGTNHNAFDNPDYWHSRSFHKTKAVRT 1438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERBB3	NP_001973.2	Recep_L_domain	56..167	CDD:460032	60/110 (55%)
		Furin-like	183..329	CDD:395614	95/145 (66%)
		Recep_L_domain	353..474	CDD:460032	75/125 (60%)
		GF_recep_IV	499..630	CDD:464344	82/132 (62%)
		TM_ErbB3	638..676	CDD:213056	10/37 (27%)
		PTK_HER3	701..979	CDD:173656	211/277 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	980..999		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1152		43/124 (35%)
erbb3a	XP_005165758.1	Recep_L_domain	64..176	CDD:460032	60/111 (54%)
		Furin-like	188..337	CDD:395614	97/149 (65%)
		Recep_L_domain	362..488	CDD:460032	75/125 (60%)
		GF_recep_IV	518..650	CDD:464344	81/131 (62%)
		TM_ErbB3	662..697	CDD:213056	9/34 (26%)
		PTK_HER3	722..1000	CDD:173656	211/277 (76%)