DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERBB3 and Egfr

DIOPT Version :9

Sequence 1:NP_001973.2 Gene:ERBB3 / 2065 HGNCID:3431 Length:1342 Species:Homo sapiens
Sequence 2:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster


Alignment Length:1448 Identity:473/1448 - (32%)
Similarity:662/1448 - (45%) Gaps:343/1448 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    28 VCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIV-LTGHNADLSFLQWIREVTGYVLVAM 91
            :|.||.:.|||..:.|:.|:.|...|..|..|.||||:. |...|.|||||..|||||||:|::.
  Fly   101 ICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISH 165

Human    92 NEFSTLPLPNLRVVRGTQVY-----DGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEK 151
            .:...:..|.|:::||..::     :.|:|:||..:       .:..|.:..|.::|:|.|....
  Fly   166 VDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTYS-------KMYTLEIPDLRDVLNGQVGFHN 223

Human   152 NDKLCHMDTIDWRDIVRDRDAEIVVKDNG-------------RSCPPCHEVCKGRCWGPGSEDCQ 203
            |..||||.||.|.:||          .||             |.||.|||.|...|||.|.::||
  Fly   224 NYNLCHMRTIQWSEIV----------SNGTDAYYNYDFTAPERECPKCHESCTHGCWGEGPKNCQ 278

Human   204 TLTKTICAPQC-NGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNK 267
            ..:|..|:||| .|.|:||.|.:|||..|||||:||...||.||::|.|.|.|...||....||.
  Fly   279 KFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNP 343

Human   268 LTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACE 332
            .|:.||.||..||.||..||..||.:.:.|..:|||:||.|||  ||.|  .|.||.|.|||.|.
  Fly   344 TTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKM--DKGG--ECVPCNGPCPKTCP 404

Human   333 GTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNG--DPW-------HKIPALDPEKLNVFR 388
            |.      ..:.:.|||.|.|||.|.||:..|....:|  |.:       ..|| ||||:|.||.
  Fly   405 GV------TVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIP-LDPERLEVFS 462

Human   389 TVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGR 453
            ||:||||||||:...|...|.|.|.||.||.||.|....|:.|.:...::.||..|:||:||:|.
  Fly   463 TVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGS 527

Human   454 IYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCL 518
            :.|..||.|||..::.|..:.:.| |:::.:..|.....|...|.:|...|:..||||.|..|||
  Fly   528 VVIQHNRDLCYVSNIRWPAIQKEP-EQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCL 591

Human   519 SCRNYSRGGVCVTHCNFLNGEPREFAHEAE---CFSCHPECQPMEGTATCNGSGSDTCAQCAHFR 580
            :|:|::..|.|:..|.:::.     |::.:   |..|||||:      ||||:|:|.|.:|.|.|
  Fly   592 TCKNFNFNGTCIADCGYISN-----AYKFDNRTCKICHPECR------TCNGAGADHCQECVHVR 645

Human   581 DGPHCVSSCP-----------------HGVLGAKGPI---------------------------- 600
            ||.||||.||                 .|..|.|..|                            
  Fly   646 DGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDK 710

Human   601 --------YKYPDVQNE---------CRPCH---ENCT--------------------------- 618
                    |.:|..|..         ||.||   |.||                           
  Fly   711 CPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPA 775

Human   619 ------------------QGCKGPELQDC----------LGQTLVLIGKT-------------HL 642
                              .||.||...||          ..:|...:..|             |:
  Fly   776 DHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHV 840

Human   643 TMALTVI---------------AGLVV--IFMMLGG------------TFLYWRGRRIQNKRA-M 677
            ....|.|               |.|.|  ||::.|.            |::..:.::.:.:.. |
  Fly   841 NYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKM 905

Human   678 RRYLERGESIEPLDPSE-KANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCI 741
            ...|...|..|||.||. .||....||.|:.||||..|||.|.||.|:||||:||||::||||.|
  Fly   906 TMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAI 970

Human   742 KVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGAL 806
            |.:...:|.:|.:........:.|::|.::::||.:|..|.:.|:||.:|||.|||:||.:|..:
  Fly   971 KELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKI 1035

Human   807 GPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEA 871
            |.:.||||..||||||.||||..:|||:|||||||:::||.|::.|||:|.||..|..:...:..
  Fly  1036 GSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGG 1100

Human   872 KTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQIC 936
            |.||||:|||.|....:|.:||||::|||:|||:|||..|:..:...::|||:|.|.:|.||:||
  Fly  1101 KMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEIC 1165

Human   937 TIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLE 1001
            ::|:|..::.||.:|..:|||||:|...|...||||.|||.|         ||.:     ..:|.
  Fly  1166 SLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAI---------PGDK-----FTRLP 1216

Human  1002 EVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESC 1066
            ....:.|.||       ...||.||               .||:::..|.. |:           
  Fly  1217 AYTSQDEKDL-------IRKLAPTT---------------DGSEAIAEPDD-YL----------- 1247

Human  1067 QESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSA 1131
            |..|..|.|                        |.|....|:.:....|:..|...|  ..||..
  Fly  1248 QPKAAPGPS------------------------HRTDCTDEIPKLNRYCKDPSNKNS--STGDDE 1286

Human  1132 YHSQRHSLLTPVTPLSPPGLEEEDVNGYVMP-----DTHLKGTPSSREGTLSSVGLSS----VLG 1187
            ..|....:......|..| ::|:|   |:||     ..:.....:..:..:::||:::    ::|
  Fly  1287 TDSSAREVGVGNLRLDLP-VDEDD---YLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIG 1347

Human  1188 TEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTA 1252
            .....::.  ||:...:.......|.|:  :.:|...|.|...:...:         |:|     
  Fly  1348 VPVSVDNP--EYLLNAQTLGVGESPIPT--QTIGIPVMGVPGTMEVKV---------PMP----- 1394

Human  1253 GTTP-DEDYEYMN-RQRD 1268
            |:.| ..|:||.| .||:
  Fly  1395 GSEPTSSDHEYYNDTQRE 1412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERBB3NP_001973.2 Recep_L_domain 56..167 CDD:279382 42/116 (36%)
FU 180..215 CDD:214589 19/48 (40%)
Furin-like 183..329 CDD:279142 74/146 (51%)
FU 226..266 CDD:238021 20/39 (51%)
Recep_L_domain 353..474 CDD:279382 56/129 (43%)
GF_recep_IV 499..630 CDD:291509 60/253 (24%)
FU 500..553 CDD:238021 17/55 (31%)
FU 548..592 CDD:214589 24/63 (38%)
TM_ErbB3 638..676 CDD:213056 11/79 (14%)
PTK_HER3 701..979 CDD:173656 136/277 (49%)
Pkinase_Tyr 709..965 CDD:285015 124/255 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 980..999 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1033..1152 19/118 (16%)
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 56/128 (44%)
GF_recep_IV 572..684 CDD:291509 44/122 (36%)
FU 573..>606 CDD:238021 14/32 (44%)
FU 617..659 CDD:214589 24/47 (51%)
FU 662..716 CDD:214589 4/53 (8%)
FU 739..786 CDD:238021 5/46 (11%)
FU 784..834 CDD:214589 8/49 (16%)
PTKc_EGFR_like 930..1208 CDD:270648 137/286 (48%)
STYKc 938..1194 CDD:214568 124/255 (49%)
Recep_L_domain 128..239 CDD:279382 42/117 (36%)
Furin-like 253..401 CDD:279142 75/151 (50%)
FU 255..292 CDD:214589 18/36 (50%)
FU 302..345 CDD:238021 22/42 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 114 1.000 Domainoid score I6065
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 607 1.000 Inparanoid score I933
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45861
OrthoDB 1 1.010 - - D51516at33208
OrthoFinder 1 1.000 - - FOG0000755
OrthoInspector 1 1.000 - - otm40594
orthoMCL 1 0.900 - - OOG6_101159
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X448
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.840

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