Protein Alignment ERBB3 and Erbb3

DIOPT Version :10

• Sequence 1: NP_001973.2
• Gene: ERBB3 / 2065
• HGNCID: 3431
• Length: 1342
• Species: Homo sapiens
• Sequence 2: NP_058914.2
• Gene: Erbb3 / 29496
• RGDID: 69323
• Length: 1339
• Species: Rattus norvegicus
• Alignment Length: 1342
• Identity: 1215/1342 - (90%)
• Similarity: 1269/1342 - (94%)
• Gaps: 3/1342 - (0%)

Human     1 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEI 65
            |||...||||..|.|||||||:||||||||||||||||||||:|||||||||||:||||||||||
  Rat     1 MRATGTLQVLCFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEI 65

Human    66 VLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHA 130
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
  Rat    66 VLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHA 130

Human   131 LRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCW 195
            ||||:.||||||||||||||||||||||||||||||||.|.||||||:||.:|||||||||||||
  Rat   131 LRQLKFTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRVRGAEIVVKNNGANCPPCHEVCKGRCW 195

Human   196 GPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCP 260
            |||.:|||.||||||||||||.||||||||||||||||||||||||||||||.||||||||||||
  Rat   196 GPGPDDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRRFNDSGACVPRCP 260

Human   261 QPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGG 325
            :||||||||||||||||||||||||||||||||||||||.||||||||||||||:||||||||||
  Rat   261 EPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTFCVRACPPDKMEVDKHGLKMCEPCGG 325

Human   326 LCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTV 390
            ||||||||||||||:|||||||||||||||||||||||||||||.||||||||||||||||||||
  Rat   326 LCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNVDPWHKIPALDPEKLNVFRTV 390

Human   391 REITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIY 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
  Rat   391 REITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVY 455

Human   456 ISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSC 520
            ||||:|||||||||||::||||:|||||||::||..:|:||||||||||||||||||||||||||
  Rat   456 ISANQQLCYHHSLNWTRLLRGPSEERLDIKYDRPLGECLAEGKVCDPLCSSGGCWGPGPGQCLSC 520

Human   521 RNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHC 585
            |||||.||||||||||.||||||.|||:||||||||.|||||:||||||||.||:||||||||||
  Rat   521 RNYSREGVCVTHCNFLQGEPREFVHEAQCFSCHPECLPMEGTSTCNGSGSDACARCAHFRDGPHC 585

Human   586 VSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIA 650
            |:|||||:||||||||||||.|||||||||||||||.||||||||||..||:.|.||.:|:||
  Rat   586 VNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCNGPELQDCLGQAEVLMSKPHLVIAVTV-- 648

Human   651 GLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVL 715
            ||.||.|:|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   649 GLAVILMILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVL 713

Human   716 GSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG 780
            |||||||||||:|||||||||||||||||||||||||||||||||||:|||||||||||||||||
  Rat   714 GSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPG 778

Human   781 SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSP 845
            |||||||||||||||||||:|||..|||||||||||||||||||||||.||||:||.|||:||||
  Rat   779 SSLQLVTQYLPLGSLLDHVKQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSP 843

Human   846 SQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAE 910
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
  Rat   844 SQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAE 908

Human   911 PYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRY 975
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   909 PYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRY 973

Human   976 LVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNR 1040
            |||||.||||..|..||..||.|:|:|.||||||||||||||||:.|| |:||||||||.|||.|
  Rat   974 LVIKRASGPGTPPAAEPSVLTTKELQEAELEPELDLDLDLEAEEEGLA-TSLGSALSLPTGTLTR 1037

Human  1041 PRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSE 1105
            |||||||||||||||||||.:|||:|.:|||.|..|:..||:||||:|||..|||||||||||||
  Rat  1038 PRGSQSLLSPSSGYMPMNQSSLGEACLDSAVLGGREQFSRPISLHPIPRGRPASESSEGHVTGSE 1102

Human  1106 AELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTP 1170
            ||||||||:|||||||||||||||||||||||||||||||||||||||||.||||||||||:|..
  Rat  1103 AELQEKVSVCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDGNGYVMPDTHLRGAS 1167

Human  1171 SSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASL 1235
            ||||||||||||||||||||||||||||||||:||.|||.||||.||||||||||||||||||||
  Rat  1168 SSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGSPPRPPRPGSLEELGYEYMDVGSDLSASL 1232

Human  1236 GSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGH 1300
            ||||||||||:.|:|:||||||||||||||:|..||.||||||||||||:|||||||||||||||
  Rat  1233 GSTQSCPLHPMAIVPSAGTTPDEDYEYMNRRRGAGGAGGDYAAMGACPAAEQGYEEMRAFQGPGH 1297

Human  1301 QAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT 1342
            .||||.||||||||||||||||||||||||||||||||||||
  Rat  1298 HAPHVRYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT 1339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERBB3	NP_001973.2	Recep_L_domain	56..167	CDD:460032	107/110 (97%)
		Furin-like	183..329	CDD:395614	137/145 (94%)
		Recep_L_domain	353..474	CDD:460032	116/120 (97%)
		GF_recep_IV	499..630	CDD:464344	118/130 (91%)
		TM_ErbB3	638..676	CDD:213056	26/37 (70%)
		PTK_HER3	701..979	CDD:173656	266/277 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	980..999		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1152		100/118 (85%)
Erbb3	NP_058914.2	Recep_L_domain	56..167	CDD:460032	107/110 (97%)
		Furin-like	182..329	CDD:395614	137/146 (94%)
		Recep_L_domain	353..474	CDD:460032	116/120 (97%)
		GF_recep_IV	499..630	CDD:464344	118/130 (91%)
		TM_ErbB3	638..674	CDD:213056	26/37 (70%)
		Protein Kinases, catalytic domain	699..977	CDD:473864	266/277 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1023..1052		25/28 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1078..1215		123/136 (90%)