DRSC/TRiP Functional Genomics Resources

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Protein Alignment ERBB3 and let-23

DIOPT Version :10

Sequence 1:NP_001973.2 Gene:ERBB3 / 2065 HGNCID:3431 Length:1342 Species:Homo sapiens
Sequence 2:NP_001300607.1 Gene:let-23 / 174462 WormBaseID:WBGene00002299 Length:1335 Species:Caenorhabditis elegans


Alignment Length:1360 Identity:371/1360 - (27%)
Similarity:559/1360 - (41%) Gaps:353/1360 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    27 AVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEI-----------------VLTGHNAD- 73
            :||.||.||:|..|.. |..:.|..:|..|..|.|||||                 .:...|.| 
 Worm    50 SVCSGTTNGISRYGTG-NILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDS 113

Human    74 ----LSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQL 134
                ::|...:.|:.|.:::.......:..|.|||:.|.:|:... |:::..|...:.. .:|:|
 Worm   114 PLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVFHDN-ALYIHKNDKVHEV-VMREL 176

Human   135 RLTQLTEILSGGVYIEKNDKLCHM-DTIDWRDIVRDRDAEIV--------VKDNGRSCPPCHEVC 190
            |:     |.:|.|.|:.|.|:|:: |.|||::::.|.|.:.|        ...||:|...|||.|
 Worm   177 RV-----IRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC 236

Human   191 KGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPN---QCCHDECAGGCSGPQDTDCFACRHFNDS 252
            ..:|||.|..|||.:.:::|...|: .||..|..   :||...|.|||:|....:|.||..:...
 Worm   237 NDKCWGSGDNDCQRVYRSVCPKSCS-QCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELD 300

Human   253 GACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGL 317
            |.|:..||...::|..|.:|..||..:||.|..||..||...:::...|||.|...........:
 Worm   301 GICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDVCVRHCSDGHHYDATKDV 365

Human   318 KMCEPC-GGLCPKACEGTGSGSRFQTVDS-------SNIDGFVNCTKILGNLDFLITGLNGDPWH 374
            :.||.| ...|||.|          |||.       .|::|   |.:|.|:|  :|.       |
 Worm   366 RECEKCRSSSCPKIC----------TVDGHLTNETLKNLEG---CEQIDGHL--IIE-------H 408

Human   375 KIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVT 439
               |...|:|.|..||:.::.|:.|..  .:.::.....||..|.||.|:|..::|.|.:..::.
 Worm   409 ---AFTYEQLKVLETVKIVSEYITIVQ--QNFYDLKFLKNLQIIEGRKLHNVRWALAIYQCDDLE 468

Human   440 SLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEER---LDIKHNRPRRDCVAEGKVCD 501
            .|...|||.|..|.:.|..|.:|||...::|:.::....::.   |.|..||..:.|..|.:|||
 Worm   469 ELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCD 533

Human   502 PLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCN---FLNGEPREFAHEAECFSCHPECQPMEGTA 563
            ..|:..||||..|..||.|:.:...|.||..|:   ||..:.     ..:|..|.|||:      
 Worm   534 KNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKGFLRNQT-----SMKCERCSPECE------ 587

Human   564 TCNGSGSDTCAQCAH-------FRDGPHCVSSCP--------------HGVL---GAKGP----- 599
            ||||.|...|..|.|       |.:...||..||              |...   |..||     
 Worm   588 TCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNGCTGPDSNLG 652

Human   600 ---------IYKY---------------------------------------------------- 603
                     ..||                                                    
 Worm   653 YGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSS 717

Human   604 -------------------------------------PDVQNE-CRPCHENCTQ----------G 620
                                                 ||..|. |:.||..|.|          |
 Worm   718 AGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTG 782

Human   621 C---------KG-----------------PELQDCLGQTLV-LIGKTHLTMALTVIAGLVVIFMM 658
            |         ||                 |...:||...:. ...||.:.:..:|:.|..|:|:.
 Worm   783 CQKCKNFTVFKGDIAQCVSECPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLF 847

Human   659 LGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELR-KL-KVLGSGVFG 721
            :  ..:|||.:||..|..:...::..| :.|:|.|.:.|.....:...:||: || |.||:|.||
 Worm   848 I--LLVYWRCQRIGKKLKIAEMVDMPE-LTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFG 909

Human   722 TVHKGVWIPE-GESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGS----LDHAHIVRLLGLC-PG 780
            ||..|::.|: .:::||||.|||.      |:.|:.||.||...:    |.|.::::::|.| ..
 Worm   910 TVFAGIYYPKRAKNVKIPVAIKVF------QTDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHD 968

Human   781 SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSP 845
            ..|::||.|.|||:|.:.::.|:..||.:..:.:..|||.||.|||:..:|||:||.||||:|..
 Worm   969 DGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKF 1033

Human   846 SQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAE 910
            :.|::.|||::.:|..|...:.....|..|||:|:|......|||.||||::|||.||::|||..
 Worm  1034 NHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQS 1098

Human   911 PYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRY 975
            ||.|:....:.:.|:.|.||:||..|:.|:|..:::|||.|...||.|:.|...|....:.|..:
 Worm  1099 PYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLF 1163

Human   976 LVIKRESGPGIAPGPEPHGLTNKKLEEVELEPE-----------LDLDLDLEAEEDNLATTTLGS 1029
            |.                  .:.|:.|.:|..|           .|.::|.:...|.      ||
 Worm  1164 LE------------------NSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQ------GS 1204

Human  1030 ALSLP-----VGTLNRPRGS-----QSLLSPSSGYMPMNQGNLGE-----------SCQESAV-- 1071
            ..|:|     :.|...|.|.     ||:.|......|.:.|:..:           ..|:|||  
 Worm  1205 LPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLY 1269

Human  1072 ------SGSSERCPRPVSLHPMPRGCLASES--SEGHV------TGSEAEL----QEKVS 1113
                  .|.:|..|.....:..|....:|..  :|.|:      |..|||.    .|:||
 Worm  1270 TAVTNEDGQTELSPSNGDYYNQPNTPSSSSGYYNEPHLKTKKPETSEEAEAVQYENEEVS 1329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERBB3NP_001973.2 Recep_L_domain 56..167 CDD:460032 34/133 (26%)
Furin-like 183..329 CDD:395614 50/149 (34%)
Recep_L_domain 353..474 CDD:460032 35/120 (29%)
GF_recep_IV 499..630 CDD:464344 55/297 (19%)
TM_ErbB3 638..676 CDD:213056 12/37 (32%)
PTK_HER3 701..979 CDD:173656 110/285 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 980..999 0/18 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1033..1152 27/122 (22%)
let-23NP_001300607.1 Recep_L_domain 77..205 CDD:460032 34/134 (25%)
Furin-like 229..378 CDD:395614 50/149 (34%)
Recep_L_domain 396..503 CDD:460032 36/123 (29%)
GF_recep_IV 531..652 CDD:464344 40/131 (31%)
FU 702..752 CDD:214589 0/49 (0%)
FU 759..806 CDD:214589 10/46 (22%)
PK_Tyr_Ser-Thr 898..1153 CDD:462242 105/260 (40%)

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