Protein Alignment ERBB3 and Erbb3

DIOPT Version :10

• Sequence 1: NP_001973.2
• Gene: ERBB3 / 2065
• HGNCID: 3431
• Length: 1342
• Species: Homo sapiens
• Sequence 2: NP_034283.1
• Gene: Erbb3 / 13867
• MGIID: 95411
• Length: 1339
• Species: Mus musculus
• Alignment Length: 1341
• Identity: 1217/1341 - (90%)
• Similarity: 1265/1341 - (94%)
• Gaps: 3/1341 - (0%)

Human     1 MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEI 65
            |.|...|||||.|.|||||||:||||||||||||||||||||:|||||||||||:||||||||||
Mouse     1 MSAIGTLQVLGFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEI 65

Human    66 VLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHA 130
            ||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
Mouse    66 VLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHA 130

Human   131 LRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCW 195
            |||||.|||||||.||||||||||||||||||||||||..|||||||:||.:|||||||||||||
Mouse   131 LRQLRFTQLTEILLGGVYIEKNDKLCHMDTIDWRDIVRVPDAEIVVKNNGGNCPPCHEVCKGRCW 195

Human   196 GPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCP 260
            |||.||||.||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
Mouse   196 GPGPEDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCP 260

Human   261 QPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGG 325
            .||||||||||||||||.|||||||||||||||||||||.||||||.||||||||||||||||.|
Mouse   261 APLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRG 325

Human   326 LCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTV 390
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 LCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTV 390

Human   391 REITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIY 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|
Mouse   391 REITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVY 455

Human   456 ISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSC 520
            ||||:|||||||||||::||||.|||||||:|||..:||||||||||||||||||||||||||||
Mouse   456 ISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSC 520

Human   521 RNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHC 585
            |||||.||||||||.|.||||||.|||.||||||||||||||:||||||||.||:||||||||||
Mouse   521 RNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFRDGPHC 585

Human   586 VSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIA 650
            |:|||||:||||||||||||.||||||||||||||||||||||||||..||:.|.||.:|:||
Mouse   586 VNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVLMSKPHLVIAVTV-- 648

Human   651 GLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVL 715
            ||.|||::|||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   649 GLTVIFLILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVL 713

Human   716 GSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG 780
            |||||||||||:|||||||||||||||||||||||||||||||||||:|||||||||||||||||
Mouse   714 GSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPG 778

Human   781 SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSP 845
            |||||||||||||||||||||||..|||||||||||||||||||||||.||||:||.|||:||||
Mouse   779 SSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSP 843

Human   846 SQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAE 910
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   844 SQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAE 908

Human   911 PYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRY 975
            |||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   909 PYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRY 973

Human   976 LVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNR 1040
            |||||.|||||.|..||..|:.|:|::.||||:||||||:|.||:.|| ||||||||||.|||.|
Mouse   974 LVIKRASGPGIPPAAEPSALSTKELQDAELEPDLDLDLDVEVEEEGLA-TTLGSALSLPTGTLTR 1037

Human  1041 PRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSE 1105
            |||||||||||||||||||.||||:|.:|||.|..|:..||:||||:|||...||||||||||||
Mouse  1038 PRGSQSLLSPSSGYMPMNQSNLGEACLDSAVLGGREQFSRPISLHPIPRGRQTSESSEGHVTGSE 1102

Human  1106 AELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTP 1170
            |||||:||||||||||||||||||||||||||||||||||||||||||||.||||||||||:||.
Mouse  1103 AELQERVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDGNGYVMPDTHLRGTS 1167

Human  1171 SSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASL 1235
            ||||||||||||||||||||||||||||||||:||.||..||||.||||||||||||||||||||
Mouse  1168 SSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGSPARPPRPGSLEELGYEYMDVGSDLSASL 1232

Human  1236 GSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGH 1300
            ||||||||||:.|:|:||||||||||||||:|..||.||||||||||||:|||||||||||||||
Mouse  1233 GSTQSCPLHPMAIVPSAGTTPDEDYEYMNRRRGAGGSGGDYAAMGACPAAEQGYEEMRAFQGPGH 1297

Human  1301 QAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQR 1341
            |||||.|||||||||||||||||||||||||||||||||||
Mouse  1298 QAPHVRYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQR 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERBB3	NP_001973.2	Recep_L_domain	56..167	CDD:460032	107/110 (97%)
		Furin-like	183..329	CDD:395614	137/145 (94%)
		Recep_L_domain	353..474	CDD:460032	117/120 (98%)
		GF_recep_IV	499..630	CDD:464344	119/130 (92%)
		TM_ErbB3	638..676	CDD:213056	26/37 (70%)
		PTK_HER3	701..979	CDD:173656	267/277 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	980..999		10/18 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1152		100/118 (85%)
Erbb3	NP_034283.1	Recep_L_domain	56..167	CDD:460032	107/110 (97%)
		Furin-like	179..329	CDD:395614	139/149 (93%)
		Recep_L_domain	353..474	CDD:460032	117/120 (98%)
		GF_recep_IV	499..630	CDD:464344	119/130 (92%)
		TM_ErbB3	638..674	CDD:213056	26/37 (70%)
		Protein Kinases, catalytic domain	699..977	CDD:473864	267/277 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1028..1052		21/23 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1077..1156		71/78 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1181..1212		26/30 (87%)