DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERBB3 and erbb3

DIOPT Version :10

Sequence 1:NP_001973.2 Gene:ERBB3 / 2065 HGNCID:3431 Length:1342 Species:Homo sapiens
Sequence 2:XP_012813260.1 Gene:erbb3 / 100493384 XenbaseID:XB-GENE-853369 Length:1347 Species:Xenopus tropicalis


Alignment Length:1387 Identity:805/1387 - (58%)
Similarity:959/1387 - (69%) Gaps:133/1387 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    25 SQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLV 89
            ||.||.||:|||||:||::.|..||..:|..|::|||||||||..:..|||||..|||||||||:
 Frog    25 SQNVCSGTMNGLSVSGDSDYQLFTLKNMYSNCQIVMGNLEIVLIDNKGDLSFLTSIREVTGYVLI 89

Human    90 AMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDK 154
            |:|.|:.|||.||||:||..:||.|:|:::.||...|.|..:.:|...:|||||:|||:|.|||.
 Frog    90 AVNIFTYLPLENLRVIRGAHLYDKKYALYMSLNNQINGSLGIEKLGFHKLTEILAGGVHITKNDH 154

Human   155 LCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCF 219
            ||..|||:|:|||:|..|.|.::.|.::|.||.:.|.|.||||...||||||||:||.||||.||
 Frog   155 LCFTDTINWKDIVQDSKAAIEIESNSKACKPCDQACDGNCWGPEKTDCQTLTKTVCAEQCNGRCF 219

Human   220 GPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGG 284
            |.||.:||||||||||:...:..||.|||||||.||||.|||||:||||||||||||..||||||
 Frog   220 GKNPTECCHDECAGGCTDSSNLKCFVCRHFNDSEACVPHCPQPLIYNKLTFQLEPNPDAKYQYGG 284

Human   285 VCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNID 349
            .||.|||.||||||:|||||||.:||||:|||:||||||.||||||||||..||.:|||||||||
 Frog   285 SCVKSCPRNFVVDQSSCVRACPSNKMEVEKNGVKMCEPCSGLCPKACEGTLHGSTYQTVDSSNID 349

Human   350 GFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSN 414
            .|:||||||||||||..|::||.|..|.||||:||:||:||:||||||||||||..:.:|||||:
 Frog   350 KFINCTKILGNLDFLTIGIDGDLWRNITALDPKKLSVFKTVKEITGYLNIQSWPKSLTDFSVFSS 414

Human   415 LTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTE 479
            |:|||||:|:.||||||:|||.||||||||||:|||||::||:.|:.|||..::|||.:......
 Frog   415 LSTIGGRTLHTRGFSLLVMKNSNVTSLGFRSLQEISAGKVYIAENQNLCYCDTVNWTSLFPTYPR 479

Human   480 ERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFA 544
            :..:||.||.:..||.||||||||||:.||||.||.||||||||||.|||:..|||..|:.||:|
 Frog   480 QSTEIKGNRKKNKCVEEGKVCDPLCSNNGCWGSGPDQCLSCRNYSRNGVCLQSCNFTEGDEREYA 544

Human   545 HEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNE 609
            ....|..||.|||.|||..:|||||.|.|.||.::|||.||||.||:|:||...||:||||...:
 Frog   545 KAGVCLKCHEECQKMEGRLSCNGSGPDGCVQCVNYRDGLHCVSQCPNGILGKDRPIFKYPDANKD 609

Human   610 CRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG-----GTFLYWRGR 669
            |:|||||||.||.|||::.|.|....:|.....|:   |:|.:|..|.:|.     || |||||:
 Frog   610 CQPCHENCTHGCTGPEIKHCTGIAAPIISSNTPTV---VVAAVVATFFVLCCCALLGT-LYWRGQ 670

Human   670 RIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGES 734
            :|:|||||||||||||.::.||||||.|.|.||:||:|||:|||:||||||||||||||||:|||
 Frog   671 KIRNKRAMRRYLERGECLDMLDPSEKTNTVQARLFKDTELKKLKILGSGVFGTVHKGVWIPDGES 735

Human   735 IKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHV 799
            ||||||||||.|::|||:|.||||||||||||||.:||||||:||||.|||||.|||:||||.||
 Frog   736 IKIPVCIKVILDRTGRQTFHAVTDHMLAIGSLDHTYIVRLLGICPGSQLQLVTAYLPMGSLLQHV 800

Human   800 RQHR--GALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPD 862
            |:::  ||:||||||||.|||||||.|||||.||||||:|||||:||.:||||:|:||||||.||
 Frog   801 RKNKDSGAIGPQLLLNWCVQIAKGMCYLEEHRMVHRNLSARNVLMKSVNQVQVSDYGVADLLYPD 865

Human   863 DKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKG 927
            ||:..|:|.|||:|||||||||||||||||||||||||:||:||||||||.|:||:|||||||||
 Frog   866 DKKFCYNEIKTPVKWMALESIHFGKYTHQSDVWSYGVTLWEMMTFGAEPYTGIRLSEVPDLLEKG 930

Human   928 ERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGP-E 991
            |||:||||||||||||||||||||||||||||||.|||||||||||||||:.|.|....:|.| :
 Frog   931 ERLSQPQICTIDVYMVMVKCWMIDENIRPTFKELGNEFTRMARDPPRYLVVTRNSDALQSPLPGD 995

Human   992 PHGLTNKKLEEVELEPELDLDLDLEAE----EDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSS 1052
            |..|:.|::.::    |.|:|.|||:|    :....||...|...:....      |||.||..:
 Frog   996 PPPLSEKQVSDL----ESDVDTDLESEDMAMQPKTPTTLYASRQRIDYSR------SQSALSSIA 1050

Human  1053 GYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPR----------GCLASESSEGHVTGSEAE 1107
            ||:||||    ..|       ||.|.....|..|:||          |...||||||..|.|:.|
 Frog  1051 GYLPMNQ----SLC-------SSSRKGTMTSAEPIPRHGTRRREDSLGRTVSESSEGCCTSSDLE 1104

Human  1108 LQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSS 1172
            ..|..|. ...|.|...|.|.||||.|||.|||.. ||        :|.:.|:||.  |..:..|
 Frog  1105 TIEDNSY-GGGSLSHISRSRLDSAYRSQRESLLVG-TP--------DDDSEYIMPG--LSQSEIS 1157

Human  1173 REGTLSSVG---LSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSAS 1234
            |:|||:|.|   |:..|....::|||||||||::         :|||.|:|.|||||:.....||
 Frog  1158 RDGTLTSQGSRSLTPCLVNATDEEDEEYEYMNKK---------KPSSKEKLEYEYMDIRGTGDAS 1213

Human  1235 LGSTQSCPLHPVPIMPTAGTTP-------DEDYEYMN-------RQRDGGGPGGDYAAMGAC--- 1282
                ..|    :...|..|...       .|||||||       |:..|.|...:|..|...   
 Frog  1214 ----NEC----IAFSPAEGDKEGDYEYGNKEDYEYMNEKGKYTSRESLGDGDLEEYTYMNRSGKV 1270

Human  1283 -----PASEQGYEEM----------------------RAFQGPGHQAPHVHYARLKTLRSLEATD 1320
                 ...:||||:|                      .|.|...||          .||:|||.|
 Frog  1271 KDETKTEDKQGYEDMNLVANLPQQLERPTVIPQTCHREALQKGYHQ----------PLRALEAKD 1325

Human  1321 SAFDNPDYWHSRLFPKANAQRT 1342
            .|||||||||||||.|.:.|.|
 Frog  1326 CAFDNPDYWHSRLFSKTDLQMT 1347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERBB3NP_001973.2 Recep_L_domain 56..167 CDD:460032 64/110 (58%)
Furin-like 183..329 CDD:395614 108/145 (74%)
Recep_L_domain 353..474 CDD:460032 84/120 (70%)
GF_recep_IV 499..630 CDD:464344 82/130 (63%)
TM_ErbB3 638..676 CDD:213056 16/42 (38%)
PTK_HER3 701..979 CDD:173656 233/279 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 980..999 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1033..1152 47/128 (37%)
erbb3XP_012813260.1 Recep_L_domain 55..167 CDD:460032 64/111 (58%)
Furin-like 182..329 CDD:395614 108/146 (74%)
Recep_L_domain 353..474 CDD:460032 84/120 (70%)
GF_recep_IV 499..629 CDD:464344 82/129 (64%)
TM_ErbB3 <656..677 CDD:213056 11/21 (52%)
Protein Kinases, catalytic domain 702..981 CDD:473864 232/278 (83%)

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