DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERBB2 and erbb2

DIOPT Version :9

Sequence 1:	XP_024306409.1	Gene:	ERBB2 / 2064	HGNCID:	3430	Length:	1301	Species:	Homo sapiens
Sequence 2:	NP_956413.2	Gene:	erbb2 / 386966	ZFINID:	ZDB-GENE-031118-121	Length:	1275	Species:	Danio rerio

Alignment Length:	1354	Identity:	723/1354 - (53%)
Similarity:	873/1354 - (64%)	Gaps:	165/1354 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     9 WGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSF 73
            |.|||.|....|...:||.||||||.||:|.|.|.:|||.||.|||||.||||:|:|..|..|||
Zfish    11 WVLLLLLGITAATGREVCLGTDMKLALPSSLENHYEMLRLLYTGCQVVHGNLEITHLQGNPDLSF 75

Human    74 LQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPG-GL 137
            ||:|.||||||||||..||.:||..|||:||:||::.||||||.:|.:         .:..| ||
Zfish    76 LQEIVEVQGYVLIAHVSVRSLPLDNLRIIRGSQLYKSNYALAVHNNSN---------SSQAGLGL 131

Human   138 RELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGS 202
            |||:||||||||.|||.|..|||||:...|.|:|...|.....|.|.|..::  |..||..||..
Zfish   132 RELRLRSLTEILLGGVYIWGNPQLCFPRNINWEDTVSKVQNKPLHLQDIPKN--CPRCSSACKSG 194

Human   203 RCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLVCASALCPMCSTPQ 267
            .||||..:|||:||...|:.||:|||||.|:||||.||||||||||.||||
Zfish   195 GCWGEKDQDCQTLTSVNCSSGCSRCKGPKPSDCCHVQCAAGCTGPKDSDCL-------------- 245

Human   268 DARGGHPAWYCPIAPGTPGQNSTVKASHLSPQACLHFNHSGICELHCPALVTYNTDTFESMPNPE 332
                                            ||.|||.||.|:..||....|:..||:|.||.:
Zfish   246 --------------------------------ACRHFNDSGTCKDSCPPPTIYDPITFQSKPNKD 278

Human   333 GRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTA--EDG--TQRCEKCSKPCARVCYGLGM 393
            .:::|||:||..||:|||:.:| :||:|||..|:||.:  .||  ||:||||...|.:|||||||
Zfish   279 KKFSFGATCVKQCPHNYLAMEV-ACTMVCPKANKEVISVEPDGQETQKCEKCEGECPKVCYGLGM 342

Human   394 EHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYI 458
            .:|:.|..|.|.||..|.||:||:||||||.:||.|:..:|::.|||..|:..:|:|||||||||
Zfish   343 GNLQGVSVVNSTNIGMFTGCEKIYGSLAFLSDSFKGNADTNSSGLQPSDLEKLKTIEEITGYLYI 407

Human   459 SAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFV 523
            .||.::|.|||||:||:||||::|:.|.:||.:|.|.|..|||||||.:..||.|||:|:.||:.
Zfish   408 DAWSENLLDLSVFENLKVIRGQMLYKGVFSLGVQSLQIESLGLRSLRSVSGGLVLIHNNSRLCYT 472

Human   524 HTVPWDQLFRNPHQA--LLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC 586
            .::||..|. :|.|.  |:...|:.:..||.||..|..||....||||||:|||:|..:.||.||
Zfish   473 SSLPWTSLL-HPTQGPNLISNNNKDQQTCVSEGKICDPLCGDSGCWGPGPSQCVSCLNYKRGTEC 536

Human   587 VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVK 651
            ||.|.||.|..||:.:..:|:||||||:|.||:.:|.||..|||..|.|::|...||.|||||||
Zfish   537 VELCNVLHGSVREFEDGFNCVPCHPECRPINGTASCTGPGPDQCTDCMHFQDGDVCVERCPSGVK 601

Human   652 PDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVV 716
            .:  ...:||:.:..|.|.||..|||.|| .|||:|||.:|:..|.|::...|.|:||.::|..:
Zfish   602 EE--QHTVWKYSNATGHCLPCETNCTVSC-PLDDRGCPIQQKTGPGTTVAITVGGVLLFIILLAL 663

Human   717 FGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVY 781
            ....::|::.:.:|.|:||.|||.||||||||||||||||||||||||||:|::||||||||||:
Zfish   664 LVFYLRRQKHQKKKETIRRRLQEHELVEPLTPSGAMPNQAQMRILKETELKKLRVLGSGAFGTVF 728

Human   782 KGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQL 846
            ||||.||||||:||||||||||||||||||||||||||||||.||||.|||||||||||||||||
Zfish   729 KGIWAPDGENVRIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCRLLGICLTSTVQLVTQL 793

Human   847 MPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFG 911
            ||||||||:||||:.|:|||.||:||:||||||||||:||||||||||||||||:||||||||||
Zfish   794 MPYGCLLDYVRENKDRIGSQYLLSWCVQIAKGMSYLEEVRLVHRDLAARNVLVKNPNHVKITDFG 858

Human   912 LARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPARE 976
            |||||||||.||||||||||||||||||||.|:|||||||||||||||||||||.|||:...||:
Zfish   859 LARLLDIDEKEYHADGGKVPIKWMALESILHRKFTHQSDVWSYGVTVWELMTFGMKPYESFQARD 923

Human   977 IPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNED-L 1040
            ||:|||.||||.||..||.:|||||||||.||.:.||||::||.||:.|||||.|:||||||| :
Zfish   924 IPELLEAGERLSQPCNCTKEVYMIMVKCWQIDPDNRPRFKDLVDEFTTMARDPSRYVVIQNEDQM 988

Human  1041 GPASPLDSTFYRSLL--EDDDMGDLVDAEEYLVPQQG--FFCPDPAPGAGGMVHHRHRSSSTR-- 1099
            ..:||:||.|:|.|:  |..::.:.:|||||||||.|  |.........|...||.|||:...
Zfish   989 SLSSPVDSEFFRILMAEEGGNVKEFLDAEEYLVPQPGSIFNTHGEMRANGPSRHHSHRSTDQMVE 1053

Human  1100 ----SGGGDL-------------TL-------GLEPSEEEAP--RSPLAPSEGAGSD-VF-DGDL 1136
                ..|.:|             ||       |:.|..:..|  ||....|.|..|| || ||.:
Zfish  1054 VDGLPNGRELYSSVSMIEQSQYPTLPVGATANGMWPGTQYPPLARSISHRSAGGQSDSVFLDGYV 1118

Human  1137 GMGAAKGLQSLPTHDPSPLQRYSEDPTVPL----PSETDG------YVAPLTCSPQPEYVNQPDV 1191
            .       .|.|   ||...|||:|||:|.    ..||||      :..|.....||||||| |:
Zfish  1119 E-------DSCP---PSSPCRYSKDPTMPNGIDGDLETDGNMVFLSHTLPRGTHTQPEYVNQ-DM 1172

Human  1192 RPQPPS--PREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPH 1254
            ..:.||  ||:..           ||...|    ||:     :.|.:|||||||.|.|...|.
Zfish  1173 ASERPSTLPRKAS-----------ERRFIL----NGL-----STGNSVENPEYLVPIGSITPT-- 1215

Human  1255 PPPAFSPAFDNLYYWDQDPPERGAPPSTFKG-----------TPTAENPEYLGL 1297
                 ||||||.||.|.....:........|           ||||||||||||
Zfish  1216 -----SPAFDNPYYHDIAAKAQAVARVAINGGTNHRQPNGFMTPTAENPEYLGL 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERBB2	XP_024306409.1	Recep_L_domain	52..173	CDD:307256	72/121 (60%)
		Furin-like	189..384	CDD:307072	84/198 (42%)
		Recep_L_domain	412..532	CDD:307256	66/119 (55%)
		GF_recep_IV	557..689	CDD:317276	68/131 (52%)
		TM_ErbB2	687..730	CDD:213055	12/42 (29%)
		PTKc_HER2	758..1036	CDD:270684	233/277 (84%)
erbb2	NP_956413.2	Recep_L_domain	54..167	CDD:279382	72/121 (60%)
		Furin-like	181..335	CDD:279142	85/202 (42%)
		FU	227..267	CDD:238021	27/85 (32%)
		Recep_L_domain	361..481	CDD:279382	66/119 (55%)
		GF_recep_IV	506..636	CDD:291509	68/132 (52%)
		FU	507..557	CDD:238021	25/49 (51%)
		FU	556..599	CDD:214589	24/42 (57%)
		PTKc_HER2	705..983	CDD:270684	233/277 (84%)
		Pkinase_Tyr	713..969	CDD:285015	215/255 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194331491
Domainoid	1	1.000	447	1.000	Domainoid score	I3620
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3273
Inparanoid	1	1.050	1331	1.000	Inparanoid score	I1286
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D18379at7742
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		oto43304
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9557
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.440