DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERBB2 and Egfr

DIOPT Version :9

Sequence 1:	XP_024306409.1	Gene:	ERBB2 / 2064	HGNCID:	3430	Length:	1301	Species:	Homo sapiens
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1470	Identity:	476/1470 - (32%)
Similarity:	659/1470 - (44%)	Gaps:	384/1470 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    24 QVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPT-NASLSFLQDIQEVQGYVLIA 87
            ::|.||..:|.:|::.|.|...||..|..|..|.||||||:||. |..||||.:|:||.||:||:
  Fly   100 KICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILIS 164

Human    88 HNQVRQVPLQRLRIVRGTQLF-----EDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTE 147
            |..|::|...:|:|:||..||     |:.|||.|                :...:..|::..|.:
  Fly   165 HVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV----------------TYSKMYTLEIPDLRD 213

Human   148 ILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDC 212
            :|.|.|....|..||:..||.|.:|.............|...|.|..|...|... ||||..::|
  Fly   214 VLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHG-CWGEGPKNC 277

Human   213 QSLTRTVCAGGCA--RCKGPLPTDCCHEQCAAGCTGPKHSDCLVCASALCPMCSTPQDARGGHPA 275
            |..::..|:..||  ||.||.|.:|||..||.|||||...||:
  Fly   278 QKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCI---------------------- 320

Human   276 WYCPIAPGTPGQNSTVKASHLSPQACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGAS 340
                                    ||.:|...|:|:..||.:..||..|:....||||:|.:||:
  Fly   321 ------------------------ACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGAT 361

Human   341 CVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSA 405
            ||..|| .:|..|.|:|...||....:...|     |..|:.||.:.|.|:.:.|        :.
  Fly   362 CVKECP-GHLLRDNGACVRSCPQDKMDKGGE-----CVPCNGPCPKTCPGVTVLH--------AG 412

Human   406 NIQEFAGCKKIFGSLAFLPESFDG--DPASNTA------PLQPEQLQVFETLEEITGYLYISAWP 462
            ||..|..|..|.|::..|.::|.|  |..:|..      ||.||:|:||.|::||||||.|....
  Fly   413 NIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTH 477

Human   463 DSLPDLSVFQNLQVIRGRILHNGAY-SLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV 526
            ....:||.|:||:.|.||.|....: :|.:....:..|.:|:|:::.||..:|.||..||:|..:
  Fly   478 PQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNI 542

Human   527 PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECR 591
            .|..:.:.|.|.:....|...|.|...|..|...|....|||.|..||:.|..|.....|:.:|.
  Fly   543 RWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCG 607

Human   592 VLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCP--------- 647
            .:....:  .:.|.|..|||||:      ||.|..||.|..|.|.:|...||:.||
  Fly   608 YISNAYK--FDNRTCKICHPECR------TCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGV 664

Human   648 -----------SGVK--------------------------------PDLSYMPIWKF--PDEEG 667
                       :|.|                                || .|  .|::  |.|:|
  Fly   665 CRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPD-GY--FWEYVHPQEQG 726

Human   668 A---------CQPC-PI---------------NCTH----------------------------- 678
            :         |:.| |:               .|||
  Fly   727 SLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHP 791

Human   679 --------------SC-----VDLDDKG-------------CPAEQR--------------ASPL 697
                          ||     .|.::.|             ||.|.|              |||.
  Fly   792 ECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPP 856

Human   698 TS-------------IISAVVGILLVVVLGVVFGILIKRRQQKIRKYT--MRRLLQETELVEPLT 747
            .|             ||:..|.:..:.:|.||  ..|.|::||.:|.|  |...|...|..|||.
  Fly   857 RSSKITANLDVNMIFIITGAVLVPTICILCVV--TYICRQKQKAKKETVKMTMALSGCEDSEPLR 919

Human   748 PSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKE 812
            ||....|..::||:|:.||||..|||.||||.||||:|:|:|||||||||||.|.::|..::::|
  Fly   920 PSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEE 984

Human   813 ILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAK 877
            .|.|||:||.|....:.:||.:|::|.:.|:|||||.|||||:||.||.::||:.||||..||||
  Fly   985 FLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAK 1049

Human   878 GMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILR 942
            ||||||:.||||||||||||||::|:.|||||||||:||..|..||.|.|||:||||:|||.|..
  Fly  1050 GMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRN 1114

Human   943 RRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMI 1007
            |.||.:||||::|||:|||:|||.:|::.|||::||||:|.|.:|.||.||::|:|..::.||.:
  Fly  1115 RVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHL 1179

Human  1008 DSECRPRFRELVSEFSRMARDPQRFVVIQNEDLG--PASPLDSTFYRSLLEDD---DMGDLVDAE 1067
            |:..||.|::|.:.|:..||||.|::.|..:...  ||       |.|..|.|   .:....|..
  Fly  1180 DAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPA-------YTSQDEKDLIRKLAPTTDGS 1237

Human  1068 EYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAP------RSPLAPSEG 1126
            |.:.....:..|..|||..      ||:..|               :|.|      :.|...:..
  Fly  1238 EAIAEPDDYLQPKAAPGPS------HRTDCT---------------DEIPKLNRYCKDPSNKNSS 1281

Human  1127 AGSDVFDG---DLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQ 1188
            .|.|..|.   ::|:|..:                     :.||.:.|.|:.| ||.|.|...|.
  Fly  1282 TGDDETDSSAREVGVGNLR---------------------LDLPVDEDDYLMP-TCQPGPNNNNN 1324

Human  1189 PDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYL----TPQGGA 1249
            .:      :|.:..:.|...|...:               |:.....:|:|||||    |...|.
  Fly  1325 IN------NPNQNNMAAVGVAAGYM---------------DLIGVPVSVDNPEYLLNAQTLGVGE 1368

Human  1250 APQPH------------------PPPAFSP-AFDNLYYWD 1270
            :|.|.                  |.|...| :.|:.||.|
  Fly  1369 SPIPTQTIGIPVMGVPGTMEVKVPMPGSEPTSSDHEYYND 1408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERBB2	XP_024306409.1	Recep_L_domain	52..173	CDD:307256	47/126 (37%)
		Furin-like	189..384	CDD:307072	60/196 (31%)
		Recep_L_domain	412..532	CDD:307256	45/128 (35%)
		GF_recep_IV	557..689	CDD:317276	51/271 (19%)
		TM_ErbB2	687..730	CDD:213055	19/82 (23%)
		PTKc_HER2	758..1036	CDD:270684	163/277 (59%)
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	45/127 (35%)
		GF_recep_IV	572..684	CDD:291509	34/119 (29%)
		FU	573..>606	CDD:238021	11/32 (34%)
		FU	617..659	CDD:214589	20/47 (43%)
		FU	662..716	CDD:214589	5/56 (9%)
		FU	739..786	CDD:238021	5/46 (11%)
		FU	784..834	CDD:214589	4/49 (8%)
		PTKc_EGFR_like	930..1208	CDD:270648	163/277 (59%)
		STYKc	938..1194	CDD:214568	153/255 (60%)
		Recep_L_domain	128..239	CDD:279382	47/126 (37%)
		Furin-like	253..401	CDD:279142	62/200 (31%)
		FU	255..292	CDD:214589	13/37 (35%)
		FU	302..345	CDD:238021	21/88 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	339	1.000	Domainoid score	I1096
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	607	1.000	Inparanoid score	I933
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm40594
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.840