Protein Alignment ERBB2 and Erbb2

DIOPT Version :10

• Sequence 1: NP_001369713.1
• Gene: ERBB2 / 2064
• HGNCID: 3430
• Length: 1294
• Species: Homo sapiens
• Sequence 2: NP_058699.2
• Gene: Erbb2 / 24337
• RGDID: 2561
• Length: 1259
• Species: Rattus norvegicus
• Alignment Length: 1295
• Identity: 1106/1295 - (85%)
• Similarity: 1155/1295 - (89%)
• Gaps: 40/1295 - (3%)

Human     1 MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYL 65
            |||||.||||.||||||||.|.||||||||||||||||||||||||||||||||||||||||||:
  Rat     4 MELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYV 68

Human    66 PTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVT 130
            |.||||||||||||||||:|||||||::|||||||||||||||||.||||||||.||.:|....|
  Rat    69 PANASLSFLQDIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAAST 133

Human   131 -GASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHP 194
             |.:|.||||||||||||||||||||:.||||||||.:||||:|.||||||...|||||||||.|
  Rat   134 PGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVFRKNNQLAPVDIDTNRSRACPP 198

Human   195 CSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFN 259
            |:|.||.:.|||||.||||.||.|:|..|||||||.|||||||||||||||||||||||||||||
  Rat   199 CAPACKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFN 263

Human   260 HSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTA 324
            |||||||||||||||||||||||.||||||||||||||.||||||||:|||||||||.:||||||
  Rat   264 HSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTA 328

Human   325 EDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGVSLCQQ 389
            |||||||||||||||||||||||||||..||:||.|:|||.||||||||||||||||||
  Rat   329 EDGTQRCEKCSKPCARVCYGLGMEHLRGARAITSDNVQEFDGCKKIFGSLAFLPESFDG------ 387

Human   390 AGVQWYDLGSLQPLPPGFKQFSCLSLLSSWDYRDPASNTAPLQPEQLQVFETLEEITGYLYISAW 454
                                             ||:|..|||:||||||||||||||||||||||
  Rat   388 ---------------------------------DPSSGIAPLRPEQLQVFETLEEITGYLYISAW 419

Human   455 PDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV 519
            ||||.||||||||::|||||||:||||||||||||..|||||||||||||||||.|.||||||||
  Rat   420 PDSLRDLSVFQNLRIIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTV 484

Human   520 PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECR 584
            |||||||||||||||:.||||::|..|||.|:.|||.|||||||||||||||.||||||||||||
  Rat   485 PWDQLFRNPHQALLHSGNRPEEDCGLEGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECR 549

Human   585 VLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSY 649
            |.:|||||||:.:.||||||||||||.|.||||.|||||.|||||||...|||||||||||||||
  Rat   550 VWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACAHYKDSSSCVARCPSGVKPDLSY 614

Human   650 MPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILI 714
            |||||:|||||.||||||||||||||||::||||||||||:|.||:.|||:||.::|.||.||||
  Rat   615 MPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILI 679

Human   715 KRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWI 779
            |||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   680 KRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWI 744

Human   780 PDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGC 844
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   745 PDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGC 809

Human   845 LLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 909
            |||||||:|||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
  Rat   810 LLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 874

Human   910 DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLL 974
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   875 DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLL 939

Human   975 EKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPL 1039
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||:
  Rat   940 EKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPM 1004

Human  1040 DSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEP 1104
            |||||||||||||||||||||||||||||||.|||.||.|...|.||||||||||||:|||||||
  Rat  1005 DSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFSPDPTPGTGSTAHRRHRSSSTRSGGGELTLGLEP 1069

Human  1105 SEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAP 1169
            |||..||||||||||||||||||||.||..||||||..||.|||||||||||:|||.||||||||
  Rat  1070 SEEGPPRSPLAPSEGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAP 1134

Human  1170 LTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPE 1234
            |.||||||||||.:|:||||...|||||..|||||||||||||||||||||||||||||||||||
  Rat  1135 LACSPQPEYVNQSEVQPQPPLTPEGPLPPVRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPE 1199

Human  1235 YLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV 1294
            ||.|:.|.|..|||.|||||||||||||||:..|:|.|||.|:|||||||||||||||||
  Rat  1200 YLVPREGTASPPHPSPAFSPAFDNLYYWDQNSSEQGPPPSNFEGTPTAENPEYLGLDVPV 1259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERBB2	NP_001369713.1	Recep_L_domain	52..173	CDD:460032	100/121 (83%)
		Furin-like	189..338	CDD:395614	130/148 (88%)
		Recep_L_domain	433..521	CDD:460032	79/87 (91%)
		GF_recep_IV	550..682	CDD:464344	110/131 (84%)
		TM_ErbB2	680..723	CDD:213055	31/42 (74%)
		PTKc_HER2	751..1029	CDD:270684	275/277 (99%)
Erbb2	NP_058699.2	Recep_L_domain	55..177	CDD:460032	100/121 (83%)
		Furin-like	193..342	CDD:395614	130/148 (88%)
		Recep_L_domain	370..486	CDD:460032	103/154 (67%)
		GF_recep_IV	514..647	CDD:464344	110/132 (83%)
		TM_ErbB2	645..688	CDD:213055	31/42 (74%)
		PTKc_HER2	716..994	CDD:270684	275/277 (99%)
		PHA03247	<1037..1219	CDD:223021	148/181 (82%)