Protein Alignment ERBB2 and let-23

DIOPT Version :10

• Sequence 1: NP_001369713.1
• Gene: ERBB2 / 2064
• HGNCID: 3430
• Length: 1294
• Species: Homo sapiens
• Sequence 2: NP_001300607.1
• Gene: let-23 / 174462
• WormBaseID: WBGene00002299
• Length: 1335
• Species: Caenorhabditis elegans
• Alignment Length: 1426
• Identity: 379/1426 - (26%)
• Similarity: 566/1426 - (39%)
• Gaps: 417/1426 - (29%)

Human    25 VCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTN--------------------- 68
            ||:||...:....:... |:.|..:|:||:.|.||||:|::..|
 Worm    51 VCSGTTNGISRYGTGNI-LEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTNSTVDPKNEDSP 114

Human    69 -ASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGA 132
             .|::|..:::|::|.::|....::::...|||::.|.::|.|| ||.:..|..
 Worm   115 LKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVFHDN-ALYIHKNDK----------- 167

Human   133 SPGGLRELQLRSLTEILKGGVLIQRNPQLCY-QDTILWKDIFHKNN-QLALTLIDTNRSRACH-- 193
                :.|:.:|.|..|..|.|.||.||::|| .|.|.||::.:..: |...|   ||..:.|:
 Worm   168 ----VHEVVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVET---TNSHQHCYQN 225

Human   194 -----PCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARC---KGPLPTDCCHEQCAAGCTGPKHS 250
                 .|...| ..:|||....|||.:.|:||...|::|   ......:||...|..||||....
 Worm   226 GKSMAKCHESC-NDKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPK 289

Human   251 DCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYL-STDVGSCTLV 314
            :|:||..:...|||...||:...:|..|...:.||:|||..|..||..||...| ..||  |...
 Worm   290 NCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPELLIENDV--CVRH 352

Human   315 C-PLHNQEVTAEDGTQRCEKC-SKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFL 377
            | ..|:.:.|.:  .:.|||| |..|.::|...|  ||      |:..::...||::|
 Worm   353 CSDGHHYDATKD--VRECEKCRSSSCPKICTVDG--HL------TNETLKNLEGCEQI------- 400

Human   378 PESFDGVSLCQQAGVQWYDLGSLQPLPPGFKQFSCLSLLSSWDYRDPASNTAPLQPEQLQVFETL 442
                ||..:.:.|                            :.|            |||:|.||:
 Worm   401 ----DGHLIIEHA----------------------------FTY------------EQLKVLETV 421

Human   443 EEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTL-QGLGISWLGLRSLRELGSGLAL 506
            :.::.|:.|.  ..:..||...:|||:|.||.|||..::|.: |...:..|.|.||:.:.:|..|
 Worm   422 KIVSEYITIV--QQNFYDLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVL 484

Human   507 IHHNTHLCFVHTVPWDQLF----RNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQC 567
            |..|..||:|..:.|..:.    ::...:|....||....|..|...|.:.|.:..|||..|..|
 Worm   485 IMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDC 549

Human   568 VNCSQ---------------FLRGQ------ECVEECRVLQGLPR-EYVNARH------------ 598
            :.|..               |||.|      .|..||....||.. :.:..||
 Worm   550 LECKTWKSVGTCVEKCDTKGFLRNQTSMKCERCSPECETCNGLGELDCLTCRHKTLYNSDFGNRM 614

Human   599 -----------------CLPCHPECQPQNGSVTCFGPEAD-------QCVACAHYK-DPPFCV-- 636
                             |..|||.|. .||   |.||:::       ||.....|: |..||:
 Worm   615 ECVHDCPVSHFPTQKNVCEKCHPTCY-DNG---CTGPDSNLGYGGCKQCKYAVKYENDTIFCLQS 675

Human   637 -------------------------------------ARCPSG---------VKPDLSYMPIWKF 655
                                                 ..|.|.         |...:.|.|   .
 Worm   676 SGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQP---N 737

Human   656 PDEEGACQPCPIN--------------CTHS------CVDLDDKGC------------------- 681
            |.|......||:|              |.|.      |.:....||
 Worm   738 PSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDIAQCVSE 802

Human   682 ---------PA-----------EQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTM 726
                     ||           .||.:.:..|.|.:.|..::    .:|.:|:..|.|:|.|
 Worm   803 CPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVM----FLFILLVYWRCQRIGK--- 860

Human   727 RRLLQETELVE--PLTP--SGAMPNQAQMRILKETELRKV--KVLGSGAFGTVYKGIWIPD-GEN 784
              .|:..|:|:  .|||  :...||.:::.::..:||:..  |.||:||||||:.||:.|. .:|
 Worm   861 --KLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKN 923

Human   785 VKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICL-TSTVQLVTQLMPYGCLLDH 848
            |||||||||.:  |......|:|:||..|..:....:.:::|.|: ...:::||...|.|.|.:.
 Worm   924 VKIPVAIKVFQ--TDQSQTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNF 986

Human   849 VRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDE 913
            ::.::..||:::.:.:|.|||.||.|||..|:||||||.||||||..|||:||||||:::|..|.
 Worm   987 LKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDA 1051

Human   914 TEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGE 978
            .......|||.|||:|:|...:..:||.||||::|||.||::|||..||.|:....|.:.|:.|.
 Worm  1052 DSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGN 1116

Human   979 RLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFV----VIQNEDLGPASPL 1039
            ||.|||.|:.|:|..:::|||.|.:.||.|..|...|....:.||.|:    .|...||......
 Worm  1117 RLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERF 1181

Human  1040 DSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEP 1104
            .:...|.:.:.:     :|.:.|.  .||
 Worm  1182 QTERIREMFDGN-----IDPQMYF--DQG------------------------------------ 1203

Human  1105 SEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDP-------------- 1155
               ..|..|.:|:..|...:..||| |...:.:.|         .||..:|
 Worm  1204 ---SLPSMPSSPTSMATFTIPHGDL-MNRMQSVNS---------SRYKTEPFDYGSTAQEDNSYL 1255

Human  1156 -----------------------TVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPRE 1193
                                   |...||..|.|..|.|.|....|.|:|.::.:.|...|
 Worm  1256 IPKTKEVQQSAVLYTAVTNEDGQTELSPSNGDYYNQPNTPSSSSGYYNEPHLKTKKPETSE 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERBB2	NP_001369713.1	Recep_L_domain	52..173	CDD:460032	40/143 (28%)
		Furin-like	189..338	CDD:395614	53/161 (33%)
		Recep_L_domain	433..521	CDD:460032	32/88 (36%)
		GF_recep_IV	550..682	CDD:464344	50/286 (17%)
		TM_ErbB2	680..723	CDD:213055	14/81 (17%)
		PTKc_HER2	751..1029	CDD:270684	120/285 (42%)
let-23	NP_001300607.1	Recep_L_domain	77..205	CDD:460032	40/143 (28%)
		Furin-like	229..378	CDD:395614	53/153 (35%)
		Recep_L_domain	396..503	CDD:460032	40/159 (25%)
		GF_recep_IV	531..652	CDD:464344	29/124 (23%)
		FU	702..752	CDD:214589	10/52 (19%)
		FU	759..806	CDD:214589	5/46 (11%)
		PK_Tyr_Ser-Thr	898..1153	CDD:462242	114/256 (45%)