Protein Alignment ERBB2 and Erbb2

DIOPT Version :10

• Sequence 1: NP_001369713.1
• Gene: ERBB2 / 2064
• HGNCID: 3430
• Length: 1294
• Species: Homo sapiens
• Sequence 2: NP_001003817.1
• Gene: Erbb2 / 13866
• MGIID: 95410
• Length: 1256
• Species: Mus musculus
• Alignment Length: 1295
• Identity: 1101/1295 - (85%)
• Similarity: 1156/1295 - (89%)
• Gaps: 40/1295 - (3%)

Human     1 MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYL 65
            |||||.||||.|||||.||||.|||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYL 65

Human    66 PTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNN-TTPV 129
            |.||||||||||||||||:|||||:|:.|||||||||||||||||.||||||||.|||:| ||..
Mouse    66 PANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAA 130

Human   130 TGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHP 194
            .|.:|.||||||||||||||||||||:.||||||||.:||||:..||||||...:||||||||.|
Mouse   131 PGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPP 195

Human   195 CSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFN 259
            |:|.||.:.|||||.||||.||.|:|..|||||||.|||||||||||||||||||||||||||||
Mouse   196 CAPTCKDNHCWGESPEDCQILTGTICTSGCARCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFN 260

Human   260 HSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTA 324
            ||||||||||||:||||||||||.||||||||||||||.||||||||:|||||||||.:||||||
Mouse   261 HSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQEVTA 325

Human   325 EDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGVSLCQQ 389
            |||||||||||||||.|||||||||||..||:||.||||||||||||||||||||||||
Mouse   326 EDGTQRCEKCSKPCAGVCYGLGMEHLRGARAITSDNIQEFAGCKKIFGSLAFLPESFDG------ 384

Human   390 AGVQWYDLGSLQPLPPGFKQFSCLSLLSSWDYRDPASNTAPLQPEQLQVFETLEEITGYLYISAW 454
                                             :|:|..|||:||.|||||||||||||||||||
Mouse   385 ---------------------------------NPSSGVAPLKPEHLQVFETLEEITGYLYISAW 416

Human   455 PDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV 519
            |:|..||||||||:||||||||:||||||||||||..|||||||||||||||||.|||||||:||
Mouse   417 PESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTV 481

Human   520 PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECR 584
            |||||||||||||||:.||||:.|..|||.|:.||||||||||||||||||||||||||||||||
Mouse   482 PWDQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECR 546

Human   585 VLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSY 649
            |.:|||||||..:|||||||||||||.|.||:|.|||||.|||||||...|||||||||||||||
Mouse   547 VWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEADQCEACAHYKDSSSCVARCPSGVKPDLSY 611

Human   650 MPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILI 714
            |||||:|||||.||||||||||||||||::||||||||||:|.||:.|||:||.:::.||.||||
Mouse   612 MPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLIIVVVIGILI 676

Human   715 KRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWI 779
            |||:||||||||||||||||||||||||||:||||||||||||||||:|||||||||||||||||
Mouse   677 KRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKLKVLGSGAFGTVYKGIWI 741

Human   780 PDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGC 844
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   742 PDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGC 806

Human   845 LLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 909
            |||||||:|||||||||||||:||||||||||:||||||||||||||||||||||||||||||||
Mouse   807 LLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLL 871

Human   910 DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLL 974
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   872 DIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLL 936

Human   975 EKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPL 1039
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||:
Mouse   937 EKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPSSPM 1001

Human  1040 DSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEP 1104
            |||||||||||||||:|||||||||||||||.||||.|.|...|.||||||.|||||:|||||||
Mouse  1002 DSTFYRSLLEDDDMGELVDAEEYLVPQQGFFSPDPALGTGSTAHRRHRSSSARSGGGELTLGLEP 1066

Human  1105 SEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAP 1169
            ||||.||||||||||||||||||||.:|..||||||..||.|||||||||||:|||.||||||||
Mouse  1067 SEEEPPRSPLAPSEGAGSDVFDGDLAVGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAP 1131

Human  1170 LTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPE 1234
            |.|||||||||||:||||.|...|||.|..|||||||||||||||||||||||||||||||||||
Mouse  1132 LACSPQPEYVNQPEVRPQSPLTPEGPPPPIRPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPE 1196

Human  1235 YLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV 1294
            ||.|:.|.|.||||.|||||||||||||||:..|:|.|||||:|||||||||||||||||
Mouse  1197 YLAPRAGTASQPHPSPAFSPAFDNLYYWDQNSSEQGPPPSTFEGTPTAENPEYLGLDVPV 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ERBB2	NP_001369713.1	Recep_L_domain	52..173	CDD:460032	102/121 (84%)
		Furin-like	189..338	CDD:395614	129/148 (87%)
		Recep_L_domain	433..521	CDD:460032	77/87 (89%)
		GF_recep_IV	550..682	CDD:464344	112/131 (85%)
		TM_ErbB2	680..723	CDD:213055	30/42 (71%)
		PTKc_HER2	751..1029	CDD:270684	273/277 (99%)
Erbb2	NP_001003817.1	Recep_L_domain	52..174	CDD:460032	102/121 (84%)
		Furin-like	190..339	CDD:395614	129/148 (87%)
		Recep_L_domain	367..483	CDD:460032	100/154 (65%)
		GF_recep_IV	511..644	CDD:464344	112/132 (85%)
		TM_ErbB2	642..685	CDD:213055	30/42 (71%)
		Nuclear localization signal. /evidence=ECO:0000250	677..690		11/12 (92%)
		Required for interaction with KPNB1 and EEA1. /evidence=ECO:0000250	677..690		11/12 (92%)
		PTKc_HER2	713..991	CDD:270684	273/277 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1030..1180		121/149 (81%)
		Interaction with PIK3C2B. /evidence=ECO:0000250	1196..1198		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1200..1219		13/18 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1224..1256		25/31 (81%)