DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ERBB2 and erbb2

DIOPT Version :10

Sequence 1:NP_001369713.1 Gene:ERBB2 / 2064 HGNCID:3430 Length:1294 Species:Homo sapiens
Sequence 2:XP_002940420.3 Gene:erbb2 / 100492078 XenbaseID:XB-GENE-5938588 Length:1323 Species:Xenopus tropicalis


Alignment Length:1384 Identity:763/1384 - (55%)
Similarity:914/1384 - (66%) Gaps:180/1384 - (13%)


- Green bases have known domain annotations that are detailed below.


Human     9 WGL--LLALLPPGAAST---QVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTN 68
            |||  ||.||...||..   :|||||||||..|.|...|.:.|..:|:.|||:|||||:|||..:
 Frog     8 WGLCALLLLLRGRAAEEVMGEVCTGTDMKLLHPFSQRNHYETLSTIYRDCQVIQGNLEITYLIED 72

Human    69 ASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGAS 133
            ..:|||:||:|||||||||||.:..|||:.|||:|||||:::.||||||.|.||         :.
 Frog    73 NDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRGTQLYQERYALAVLSNSDP---------SG 128

Human   134 PGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPM 198
            ..|||||::::|||||||||:::.|.|||:|||:||.||..::|.....::..:.:|.|..|||.
 Frog   129 TAGLRELRMKNLTEILKGGVIMENNTQLCFQDTVLWADILSQSNSQRNEVVLGSSNRQCPTCSPG 193

Human   199 C------KGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLH 257
            |      |...||||..|.||.||.|:|..||.||||...|.||||||||||||||:||||||||
 Frog   194 CGSLPSGKSGFCWGEGQEYCQILTSTICNSGCQRCKGNHSTHCCHEQCAAGCTGPKNSDCLACLH 258

Human   258 FNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEV 322
            |||:|:|.||||.|.|||.:|:||:.|..|||||||||||:||||||:|:||||||.||..||||
 Frog   259 FNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCPYNYLATEVGSCTLFCPQDNQEV 323

Human   323 TAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGVSLC 387
            .. ...|:||||.|.|::||||||.:.||..:||.::.|..|.||.||||||.||.|||      
 Frog   324 IV-GNVQKCEKCDKQCSKVCYGLGRDFLRTTQAVNASIIHHFQGCTKIFGSLVFLSESF------ 381

Human   388 QQAGVQWYDLGSLQPLPPGFKQFSCLSLLSSWDYRDPASNTAPLQPEQLQVFETLEEITGYLYIS 452
                         :|                    ||....:.|..:.|:||:||||||||:||.
 Frog   382 -------------KP--------------------DPNKPNSVLNAQSLEVFKTLEEITGYIYIE 413

Human   453 AWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVH 517
            :||:.|..|:||:||:||.||:|.||||||.|:.|.||.||||||.|:.|||.||..|..|||:.
 Frog   414 SWPEELKSLNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLE 478

Human   518 TVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEE 582
            :.||..|||||.|.:|.|.|:|::.|..||..|...|....||||||:|||.|:.||||.:|:|.
 Frog   479 SAPWASLFRNPRQTILKTINKPQEACDQEGQNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIES 543

Human   583 CRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDL 647
            |.||.|.|||:||...|:||||:|.||||::||.|.||.||:.||||.|...||.:||||||.: 
 Frog   544 CNVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAHYLDGEDCVEQCPSGVKGN- 607

Human   648 SYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGI 712
            |::||||:||::..||.|.:||:|||..||::|||.....|.:..:.|.|:.||:|:.:.....:
 Frog   608 SFVPIWKYPDKDRICQLCNVNCSHSCNQLDERGCPILPDNSQVYMVASIVISILIVITISTAIVL 672

Human   713 LIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGI 777
            .|:||:|..:|:|||||||: |||||||||||:||||||||||||||:|:.:|||||||||||||
 Frog   673 YIRRRKQLKKKHTMRRLLQD-ELVEPLTPSGAIPNQAQMRILKETELKKMMILGSGAFGTVYKGI 736

Human   778 WIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPY 842
            |||||||:||||||||||||||||||||||||||||||||||||.||||||||||||||||||||
 Frog   737 WIPDGENIKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLTSTVQLVTQLMPY 801

Human   843 GCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLAR 907
            |||||:||||:.|:.|:||||||:||||||:||||||||||||||||||||||:|||||||||||
 Frog   802 GCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLAR 866

Human   908 LLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPD 972
            |||:|||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
 Frog   867 LLDVDETEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPD 931

Human   973 LLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNED-LGPA 1036
            ||||||||||||:||||||||||||||||||.||:||:||.|.|||||||.|:|||:||: |..|
 Frog   932 LLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQA 996

Human  1037 SPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLG 1101
            ||:.:.||.:||::..|.||||||||||||:|||     |.......||.|.|||||       .
 Frog   997 SPMTTQFYSALLQEVGMDDLVDAEEYLVPQRGFF-----PSEDVTSEHRSRISSTRS-------A 1049

Human  1102 LEPSEEEAPRSPLAP------------SEGAGSDVF-DGDLGMGAAKGLQSLPTHDPSPLQRYSE 1153
            .|...|:|.....||            |.|:|||.. :|:......:..:|...|      ||::
 Frog  1050 TEMQAEQALLQETAPSGAALARTMSERSGGSGSDALSEGEYVFDPPQNEESGSPH------RYTD 1108

Human  1154 DPTVPLPSETDGYVAPLTC-SPQ------PEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKT 1211
            ||......|||.......| ||.      .|||||.|     ......|:.:.|.:.:||||.|:
 Frog  1109 DPLHSGEDETDSCFFEGDCISPSIPLHLPAEYVNQKD-----GERNHSPVKSQRTSVSTLERQKS 1168

Human  1212 LSPG------------------------------------------------------------- 1215
            ....                                                             
 Frog  1169 TQERHKSTLERHKSTLERQKSTQERQKNTLERQKSTLERQKSSLDRQKSTLERQKSTLERQKAQQ 1233

Human  1216 -KNGVVKDVFA--FGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQD---PPERGAPPS 1274
             |||:|:::.:  ...:::||:||.|.|...|.     .|..||||.|||:.:   ....|.|..
 Frog  1234 CKNGLVRELRSPPALSSLDNPDYLPPPGLILPN-----GFPQAFDNPYYWNHELNLAKADGDPAQ 1293

Human  1275 TFKG--TPTAENPEYLGLD 1291
            ...|  |||||||||||||
 Frog  1294 GHNGFTTPTAENPEYLGLD 1312

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERBB2NP_001369713.1 Recep_L_domain 52..173 CDD:460032 71/120 (59%)
Furin-like 189..338 CDD:395614 100/154 (65%)
Recep_L_domain 433..521 CDD:460032 52/87 (60%)
GF_recep_IV 550..682 CDD:464344 75/131 (57%)
TM_ErbB2 680..723 CDD:213055 13/42 (31%)
PTKc_HER2 751..1029 CDD:270684 252/277 (91%)
erbb2XP_002940420.3 Recep_L_domain 56..168 CDD:460032 71/120 (59%)
Furin-like 184..340 CDD:395614 101/156 (65%)
Recep_L_domain 366..479 CDD:460032 69/151 (46%)
GF_recep_IV 511..642 CDD:464344 75/131 (57%)
PTKc_HER2 710..988 CDD:270684 252/277 (91%)
COG4372 <1153..>1317 CDD:443500 41/165 (25%)
CwlO1 <1161..>1232 CDD:443091 5/70 (7%)

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