Protein Alignment Plk2 and SAK

DIOPT Version :9

• Sequence 1: NP_690017.2
• Gene: Plk2 / 20620
• MGIID: 1099790
• Length: 682
• Species: Mus musculus
• Sequence 2: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Alignment Length: 580
• Identity: 153/580 - (26%)
• Similarity: 246/580 - (42%)
• Gaps: 159/580 - (27%)

Mouse    84 VLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKHVVQFYHYFED 148
            :|||||||..|:...|..::..|.|:|....:.......::.:|:|:|..|.|..|:|.|.:|:|
  Fly    19 LLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQD 83

Mouse   149 KENIYILLEYCS----RRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFF 209
            ...:|::||...    .|.|.||.:.   .||.|....|:|:|:||.|||...|:|||:.|.|..
  Fly    84 ANYVYLVLELAHNGELHRYMNHIARP---FTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLL 145

Mouse   210 INEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGR 274
            ::..|.:|:.|||||.:|:..:.|..|:||||||:||||:::..||..:|:|::||::||:|:||
  Fly   146 LSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGR 210

Mouse   275 PPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDR 339
            |||||..::.|...:..:.|.||:.|...|:.||..:|.|.|.:|.:|:.::.|.|.|:
  Fly   211 PPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLK------ 269

Mouse   340 LSSSCCHTVPDFHLSSPAKNFFKKAAAALFGG--------KKDKARYNDTHNKVSKEDEDIYKLR 396
             .|:..|:.|.      |.|.|.::..:...|        .::..:.....|  |...:.:.::|
  Fly   270 -CSNGGHSAPG------ALNVFSQSMESGDSGIITFASSDSRNSQQIRSVEN--SGPQQVLPQIR 325

Mouse   397 HDLKKV-----------------------------------SITQQPSKHRA----DEEPQPP-- 420
            .:.|:|                                   .....|:..:|    |....||
  Fly   326 EEFKQVHHKLPYEQTGLFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLKEDRISVPPLN 390

Mouse   421 -----PT---------TVARSGTSAVE--------NKQQIGDAIRMIVRGTLGSCSSSSECLEDS 463
                 ||         ::.|:|...:|        |:.:|.|..|
  Fly   391 TKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICR-------------------- 435

Mouse   464 TMGSVADTVARVL-------RGC--------LENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGF 513
                ::|...|::       ||.        |: :|..||:.......|..|        .||.:
  Fly   436 ----ISDDGQRIIIYQPDPGRGLPVREQPPDLQ-IPSGDCVYNYDNLPSKHW--------KKYIY 487

Mouse   514 GYQLSDHTVGVLFNNGAHMSLLPDKKT--VHYYAELGQCSVFPA-TDAPEQFISQVTVLK 570
            |.:.    ||           |...||  |.|::.||:|.:... ||...:|.|...:||
  Fly   488 GARF----VG-----------LVKSKTPKVTYFSTLGKCQLMETMTDFEIRFYSGAKLLK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plk2	NP_690017.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..67
		STKc_PLK2	77..331	CDD:271090	96/250 (38%)
		S_TKc	79..331	CDD:214567	96/250 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..432		9/48 (19%)
		POLO_box_1	500..585	CDD:240561	20/74 (27%)
		POLO_box_2	598..679	CDD:240560
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	96/250 (38%)
		S_TKc	14..267	CDD:214567	96/250 (38%)
		POLO_box_Plk4_1	382..497	CDD:240557	28/162 (17%)
		POLO_box_Plk4_2	498..596	CDD:240558	13/35 (37%)
		POLO_box_Plk4_3	657..738	CDD:240559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507604at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820