DRSC/TRiP Functional Genomics Resources

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Protein Alignment Siglec1 and side-II

DIOPT Version :9

Sequence 1:XP_036015809.1 Gene:Siglec1 / 20612 MGIID:99668 Length:1719 Species:Mus musculus
Sequence 2:NP_001014485.3 Gene:side-II / 3346206 FlyBaseID:FBgn0259213 Length:1064 Species:Drosophila melanogaster


Alignment Length:1046 Identity:228/1046 - (21%)
Similarity:344/1046 - (32%) Gaps:293/1046 - (28%)


- Green bases have known domain annotations that are detailed below.


Mouse   653 SLPSRCGSCSQRTKVSRTSNSLHVEIQKPVLEDEGVYLCEASNTLGNSSAAASFNAKATVLVI-- 715
            |.|...||   |.|....|....:||::   .|:|:|.|...   ..:|...||....:|:::  
  Fly   110 SAPEVFGS---RAKFHFDSQPATLEIKR---HDQGIYRCRVD---FRTSQTQSFRFNLSV
IILPE 165

Mouse   716 --------------TPSNTLREGTEANLTCNVNQEVAVSP-ANFSWFRNGVLWTQGS-------L 758
                          |.....:||.:..:||.|   |...| ....|..||:|....:       :
  Fly   166 QPIIMDRWGRQLNGTQLGPKQEGDDIVITCRV---VGGRPQPQVRWLVNGLLVDNQNEHNSGDVI 227

Mouse   759 ETVRLQP-VARTDA-AVYACRLLTEDGAQLS-------------APVVLSVLYAPDPPKLSALLD 808
            |...|.| |.|.|. :|:.|:.|   ..||.             .|:|:.:|   :||  |::  
  Fly   228 ENRLLWPSVQRNDLNSVFTCQAL---NTQLDKPKEKSFILDMHLKPLVVKIL---EPP--SSM-- 282

Mouse   809 VGQGHMAVFICTVDSYPLAHLSLFRGDHLL----------ATNLE----PQRPSHGR-IQAKA-- 856
            :......|...:..|.|.|.::.::|...|          :|..|    |.....|: |..:|  
  Fly   283 IADRRYEVSCESSGSRPNAIITWYKGKRQLRRTKDDISKNSTRSELSFVPTTDDDGKSITCRAEN 347

Mouse   857 -TANSLQLEVR-ELGLVDSGNYHCEATNILGSANSSLFFQVRGAWVQVSPSPELREGQAVVLSCQ 919
             ..|.|.||.. :|.:|    |....|..|||.              ::|. :::||..|...|.
  Fly   348 PNVNGLYLETMWKLNVV----YPPLVTLRLGST--------------LTPD-DIKEGDDVYFECH 393

Mouse   920 VPTGVSEGTSYSWYQDGRPLQESTSS-------TLRIAAISLRQAGAYHCQAQAPDTAIASLAAP 977
            |.:. .:.....|..:|..|:.:||:       :|.:..|:...||.|.|.|...:....|...|
  Fly   394 VQSN-PQWRKLLWLHNGIHLEHNTSARVIRSNQSLVLQKITKHYAGNYACSAINDEGETVSNQLP 457

Mouse   978 VSLHVSYTP--RHVTLSALLSTDPERLGHLVCSVQSDPPAQLQLFHRNRLVASTLQGADELA--G 1038
              |.|.|||  :|.....|:....:....:||.:|:|||.:...:..|....:...|::..:  |
  Fly   458 --LRVKYTPMCKHADRVILIGASKDETVEVVCEIQADPPPRTFRWKFNNSGETLDVGSERFSVNG 520

Mouse  1039 SNPRLHVTVLPNELRLQIHFPELEDDGTYTCEASNTLGQASAAADFDAQAVRVTVWPNATVQEGQ 1103
            |...|..|.:.:           :|.||.:|.|||.:|.......|.   |.:...|||.     
  Fly   521 SRSILKYTPVTD-----------QDYGTLSCWASNEVGTQQHPCLFQ---VVLAALPNAV----- 566

Mouse  1104 QVNLTCLVWSTHQ---DSLSYTWYKGGQQLLGARSITLPSVKVLDATSYRCGV---GLPGHAPHL 1162
               ..|.|::..:   |......|.||          ||.:.||:..|.|.|:   .|......|
  Fly   567 ---SNCTVFNRTELSVDIQCIPGYDGG----------LPQIFVLEMFSTRTGITRFNLSNAEEAL 618

Mouse  1163 SRPVTLDVL-----HAPRNLRL-TYLLETQGRQLALVLC----------TVDSRPPAQLTLS--- 1208
            .....||.|     ....:||| .|....:||..|.:|.          |.|.   ..||||   
  Fly   619 FSLENLDTLTSMMVQENNSLRLRIYSYNQKGRSAAYLLTDFIIGSTAYKTDDD---VTLTLSPVI 680

Mouse  1209 --------------------------------HGDQLVASSTEASVPNTLR-LELQDPR------ 1234
                                            ||.:..|:...|...:..: ..|:.||      
  Fly   681 VGSVLTIIIIGVAIAIRIFVVTFVHNLRRNRHHGSKATAAGVTAQPSDVFKGGNLEKPRWQHTDI 745

Mouse  1235 --PSNEGL-------------YSCSAHSPLGKANTSLELLLEGVRVKMNPSGSVPEGEPVTVTCE 1284
              .|:|.|             |...:.:....:|.|        .|....:|:.......|....
  Fly   746 KTKSSEDLVEDERDPDVIPSQYVGGSSAGSSGSNAS--------NVGSTTAGTATGSSTSTAVVA 802

Mouse  1285 DPAALSSALYAWFHNGHWLQEGPASSLQFLVTTRAHAGAYFCQVHDTQGTRSSRPASLQILYAPR 1349
            :..|.:||:           .||..:......|..|..|..........::.|...::.......
  Fly   803 NANAAASAM-----------AGPGGATSSASATDGHQFASGTAAAGGGASKWSPNGNVTTTMLTG 856

Mouse  1350 DAV-----LSSFRDSRTRLMVVIQ-----CTVDSEPPAEMVLSHNGKVLAASHERHSSASGIGHI 1404
            |||     .:.....|.:|:..:.     |:.....|:..:|...||.|..     ....|:|  
  Fly   857 DAVNATVTYNQINAQRAQLLAAVAAVGGGCSSTVISPSSSILGGLGKPLGM-----GMGMGLG-- 914

Mouse  1405 QVARNALRLQVQDVTLGDGNTYVCTAQNTLGSISTTQRLL--TETDIRVTAEPGLDVPEGTALN- 1466
                           :|.|.| |..:..:|.|.:|....|  ..:....|..|||....|..|| 
  Fly   915 ---------------MGVGGT-VIGSPTSLSSTATLAAHLQPAHSSGVGTLPPGLGSGGGYILNA 963

Mouse  1467 -LSCLL--PGGSGPTGNSSFTWFWNRH-----RLHSAP---VPTLSFTPVVRAQAGLYHCRADLP 1520
             .|..|  |.|.|..|.::.|...|||     :||..|   .|..|.:.::...||.........
  Fly   964 YASGRLHHPPGGGVPGGATHTATLNRHHHQQQQLHHHPHHQQPHHSGSSLLMGSAGSVMGVVGST 1028

Mouse  1521 TGATTS 1526
            |.||||
  Fly  1029 TTATTS 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Siglec1XP_036015809.1 IgV_CD33 27..134 CDD:409377
Ig strand B 43..47 CDD:409377
Ig strand C 62..66 CDD:409377
Ig strand E 104..108 CDD:409377
Ig strand F 118..123 CDD:409377
C2-set_2 148..235 CDD:400489
Ig strand A 148..153 CDD:409353
Ig strand B 161..169 CDD:409353
Ig strand C 178..184 CDD:409353
Ig strand D 193..199 CDD:409353
Ig strand E 203..212 CDD:409353
Ig strand G 231..239 CDD:409353
Ig strand A 245..253 CDD:409353
Ig strand A' 257..261 CDD:409353
IGc2 261..319 CDD:197706
Ig strand B 262..272 CDD:409353
Ig strand C 279..285 CDD:409353
Ig strand C' 287..290 CDD:409353
Ig strand E 296..301 CDD:409353
Ig strand F 308..316 CDD:409353
Ig strand G 319..330 CDD:409353
Ig 334..417 CDD:416386
Ig strand A' 342..345 CDD:409353
Ig strand B 346..356 CDD:409353
Ig strand C 363..369 CDD:409353
Ig strand C' 371..374 CDD:409353
Ig strand E 380..386 CDD:409353
Ig strand F 393..401 CDD:409353
Ig strand G 404..417 CDD:409353
Ig strand A' 412..415 CDD:409353
Ig 428..511 CDD:416386
Ig strand B 436..443 CDD:409353
Ig strand C 449..454 CDD:409353
Ig strand C' 456..458 CDD:409353
Ig strand D 471..477 CDD:409353
Ig strand E 480..486 CDD:409353
Ig strand F 494..502 CDD:409353
Ig_3 523..583 CDD:404760
IG 624..702 CDD:214652 13/48 (27%)
Ig_3 712..777 CDD:404760 20/90 (22%)
Ig strand A' 720..723 CDD:409353 0/2 (0%)
Ig strand B 724..734 CDD:409353 3/9 (33%)
Ig strand C 742..748 CDD:409353 1/5 (20%)
Ig strand C' 750..753 CDD:409353 1/2 (50%)
Ig strand E 759..765 CDD:409353 2/5 (40%)
Ig strand F 772..780 CDD:409353 2/7 (29%)
Ig strand G 783..796 CDD:409353 4/25 (16%)
Ig 815..895 CDD:416386 23/98 (23%)
Ig strand B 815..819 CDD:409353 1/3 (33%)
Ig strand C 828..832 CDD:409353 0/3 (0%)
Ig strand E 861..865 CDD:409353 2/3 (67%)
Ig strand F 875..880 CDD:409353 1/4 (25%)
Ig 900..975 CDD:416386 19/81 (23%)
Ig strand A' 907..910 CDD:409353 0/2 (0%)
Ig strand B 911..921 CDD:409353 3/9 (33%)
Ig strand C 928..934 CDD:409353 1/5 (20%)
Ig strand C' 936..939 CDD:409353 1/2 (50%)
Ig strand E 945..951 CDD:409353 1/12 (8%)
Ig strand F 958..968 CDD:409353 4/9 (44%)
Ig strand G 971..984 CDD:409353 4/12 (33%)
IG_like 1005..1093 CDD:214653 22/89 (25%)
Ig strand C 1026..1031 CDD:409353 0/4 (0%)
Ig strand C' 1033..1035 CDD:409353 0/1 (0%)
Ig strand D 1042..1048 CDD:409353 2/5 (40%)
Ig strand E 1051..1057 CDD:409353 0/5 (0%)
Ig strand F 1065..1073 CDD:409353 4/7 (57%)
Ig_2 1095..1167 CDD:404734 18/77 (23%)
Ig strand A' 1095..1100 CDD:409353 3/4 (75%)
Ig strand B 1105..1114 CDD:409353 2/8 (25%)
Ig strand C 1121..1126 CDD:409353 1/4 (25%)
Ig strand C' 1128..1131 CDD:409353 0/2 (0%)
Ig strand E 1133..1138 CDD:409353 0/4 (0%)
Ig strand F 1148..1156 CDD:409353 3/10 (30%)
Ig strand G 1160..1170 CDD:409353 2/9 (22%)
IG_like 1195..1258 CDD:214653 19/129 (15%)
Ig strand C 1204..1208 CDD:409353 2/3 (67%)
Ig strand E 1226..1230 CDD:409353 0/4 (0%)
Ig strand F 1240..1245 CDD:409353 2/17 (12%)
Ig 1265..1344 CDD:416386 12/78 (15%)
Ig strand A' 1271..1274 CDD:409353 1/2 (50%)
Ig strand B 1278..1284 CDD:409353 1/5 (20%)
Ig strand C 1294..1299 CDD:409353 0/4 (0%)
Ig strand C' 1301..1303 CDD:409353 0/1 (0%)
Ig strand E 1309..1314 CDD:409353 0/4 (0%)
Ig strand F 1322..1327 CDD:409353 1/4 (25%)
Ig strand G 1338..1344 CDD:409353 0/5 (0%)
Ig <1365..1440 CDD:416386 14/79 (18%)
Ig strand B 1365..1372 CDD:409353 1/11 (9%)
Ig strand C 1378..1383 CDD:409353 1/4 (25%)
Ig strand C' 1386..1388 CDD:409353 1/1 (100%)
Ig strand D 1394..1407 CDD:409353 2/12 (17%)
Ig strand E 1409..1415 CDD:409353 0/5 (0%)
Ig strand F 1424..1432 CDD:409353 2/7 (29%)
Ig_3 1450..1517 CDD:404760 24/78 (31%)
Ig strand B 1555..1561 CDD:409353
Ig <1556..1630 CDD:416386
Ig strand C 1566..1571 CDD:409353
Ig strand C' 1573..1575 CDD:409353
Ig strand D 1592..1596 CDD:409353
Ig strand E 1599..1603 CDD:409353
Ig strand F 1613..1621 CDD:409353
side-IINP_001014485.3 IG_like 55..160 CDD:214653 16/58 (28%)
Ig 57..160 CDD:299845 16/58 (28%)
Ig 188..251 CDD:299845 19/68 (28%)
Ig 289..363 CDD:299845 17/73 (23%)
IG_like 289..351 CDD:214653 12/61 (20%)
Ig_2 376..460 CDD:290606 21/101 (21%)
IG_like 383..454 CDD:214653 17/71 (24%)
Ig 470..548 CDD:299845 20/88 (23%)
IG_like 481..557 CDD:214653 21/89 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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