DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sstr4 and AstC-R1

DIOPT Version :9

Sequence 1:	NP_033245.2	Gene:	Sstr4 / 20608	MGIID:	105372	Length:	385	Species:	Mus musculus
Sequence 2:	NP_649040.2	Gene:	AstC-R1 / 40020	FlyBaseID:	FBgn0036790	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	138/417 - (33%)
Similarity:	221/417 - (52%)	Gaps:	44/417 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 APATLPPGVEDTTWTPGINASW----APDEEEEDAMGSD----------GTGTAGMVTIQCIYAL 53
            |.||......::.:|..:|..|    :..:.||...|:|          ....|.:.|: .:|..
  Fly    23 ANATNWYNTNESLYTTELNHRWISGSSTIQPEESLYGTDLPTYQHCIATRNSFADLFTV-VLYGF 86

Mouse    54 VCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRA 118
            ||::||.||.|||:|:||::||:|.||||:||||||||.|::.:||:.....:..|.||..:|:|
  Fly    87 VCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIGIPFLLYTMRICSWRFGEFMCKA 151

Mouse   119 VLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFAD 183
            .:....:..|||...|.::|.|||:||.||:.:..||...:||:::...|..|.::.||:.::|.
  Fly   152 YMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRTLHIAKVVSAIAWSTSAVLMLPVILYAS 216

Mouse   184 TRPARGGEAVACNLHWP-----HPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAG 243
            |.....|...:||:.||     |.  ...|::|||.|||..|:..|...|.|::.|:|:|..:.|
  Fly   217 TVEQEDGINYSCNIMWPDAYKKHS--GTTFILYTFFLGFATPLCFILSFYYLVIRKLRSVGPKPG 279

Mouse   244 W--QQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLI-------LSYA 299
            .  :::||:.:|:|||||.|::|::|||:|.::.|:..:........::.:.::       |.|:
  Fly   280 TKSKEKRRAHRKVTRLVLTVISVYILCWLPHWISQVALIHSNPAQRDLSRLEILIFLLLGALVYS 344

Mouse   300 NSCANPILYGFLSDNFRRSFQRVL-CLRCCLLETTGGAEEEPLDYYATALKSRGGAGCI------ 357
            ||..|||||.|||:|||:||.:.. |:.  ..:.....:.||..:.....|.|||:..:
  Fly   345 NSAVNPILYAFLSENFRKSFFKAFTCMN--KQDINAQLQLEPSVFTKQGSKKRGGSKRLLTSNPQ 407

Mouse   358 CPPLPCQQEPVQAEPGCKQVPFTKTTT 384
            .|||    .|:.|.........:.|||
  Fly   408 IPPL----LPLNAGNNNSSTTTSSTTT 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sstr4	NP_033245.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		9/37 (24%)
		7tmA_SSTR4	45..319	CDD:320639	110/287 (38%)
		TM helix 1	46..72	CDD:320639	13/25 (52%)
		TM helix 2	79..105	CDD:320639	15/25 (60%)
		TM helix 3	116..146	CDD:320639	11/29 (38%)
		TM helix 4	158..180	CDD:320639	6/21 (29%)
		TM helix 5	205..234	CDD:320639	11/28 (39%)
		TM helix 6	249..279	CDD:320639	14/29 (48%)
		TM helix 7	287..312	CDD:320639	10/31 (32%)
AstC-R1	NP_649040.2	7tm_4	88..368	CDD:304433	109/281 (39%)
AstC-R1	NP_649040.2	7tm_1	94..353	CDD:278431	96/260 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	224	1.000	Domainoid score	I2540
eggNOG	1	0.900	-	-		E33208_3BCR0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I3329
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000463
OrthoInspector	1	1.000	-	-		mtm8844
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X22
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.960