Protein Alignment EPS8 and eps8

DIOPT Version :10

• Sequence 1: XP_047284450.1
• Gene: EPS8 / 2059
• HGNCID: 3420
• Length: 842
• Species: Homo sapiens
• Sequence 2: NP_001072508.1
• Gene: eps8 / 779963
• XenbaseID: XB-GENE-996936
• Length: 788
• Species: Xenopus tropicalis
• Alignment Length: 830
• Identity: 544/830 - (65%)
• Similarity: 652/830 - (78%)
• Gaps: 50/830 - (6%)

Human    21 MNGHI-SNHPSSFGMYPSQMNGYGSSPTFSQTDREHGSKTSAKALYEQRKNYARDSVSSVSDISQ 84
            |||.| |::...||......|||.|    .::||:..||.|||::||||||||||:|||:|:.||
 Frog     1 MNGQISSSYRGGFGPGSQHPNGYDS----PRSDRQSSSKISAKSIYEQRKNYARDTVSSLSETSQ 61

Human    85 YRVEHLTTFVLDRKDAMITVDDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFP 149
            |.:|||||||:||||.::|||||||||||||||||||||||:|||||:.|||.|:::|:||||||
 Frog    62 YHIEHLTTFVMDRKDGVLTVDDGIRKLKLLDAKGKVWTQDMLLQVDDKGVSLYDVDTKSELENFP 126

Human   150 LNTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKR 214
            |:::|||||||::|.|||:||||||||.|:|.|||||||||:||:|:..||:||||||||||||:
 Frog   127 LSSVQHCQAVMNACRYDSILALVCKEPAQSKADLHLFQCDEIKASLVQRDIDSAISDSKGGKQKK 191

Human   215 RPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETP 279
            ||:|||.|:..|..|||.|.||||.|||:||||||||||||||:||::.||::..||..:|:.||
 Frog   192 RPEALRAITRNDDKIPPHPGAPAPTPPGSVTQVDVRSRVAAWSSWASEYGDYDPSRQNLDQDSTP 256

Human   280 EMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPP 344
            ||:.||||||||||||||||:||||.|||||||||||||||||.|  |:||||||||||||:|||
 Frog   257 EMLEARIDRDVQILNHILDDVEFFIMKLQKAAEAFSELSKRKKGK--KKKGPGEGVLTLRARPPP 319

Human   345 PDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVVQATGGPELASSVLSPLLNKD 409
            .:||:|||||||||.|||||||||||||||::|||||||||:|:|:|||||:||.:|||||:.||
 Frog   320 QEEFVDCFQKFKHGINLLAKLKSHIQNPSASELVHFLFTPLHMMVEATGGPDLARTVLSPLITKD 384

Human   410 TIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQDLY 474
            ::||||:.:|.:|:|||.|||.:|.|.||||||||||||||||||||||||:|....|..||:|.
 Frog   385 SLDFLNFILNKEEKQLWTSLGDSWNKYRAEWPKEQFIPPYVPRFRNGWEPPLLGCAAAPKEQELS 449

Human   475 QLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNR 539
            .||||||||||.|||||...:...:|.||.|.|::|     |...|    ||.||
 Frog   450 YLAESVANVAELQRKQEFNSVPNMYSHVSRYPPSEG-----NFEER----DQVEA---------- 495

Human   540 HIDRNYEPLKTQPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNI 604
                         ::||..||||||||::||||||||:||:|||:|||||||::||..|||||||
 Frog   496 -------------QRYALCKYDFVARNSNELSVLKDDVLEVLDDKKQWWKVRSSSGAVGFVPNNI 547

Human   605 LDIVRPPESGLGRADPPYTHTIQKQRMEY-----GPRPADTPPAPSPPPTPAPVPVPLPPSTPAP 664
            |..::|.:......:..||||||||:.:.     ||.||    ||||||.|||...||..|....
 Frog   548 LVAMKPQDQSAKPMEAAYTHTIQKQKSDLIQSQAGPIPA----APSPPPNPAPTYSPLANSQQPT 608

Human   665 VPVSKV--PANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQK 727
            :||:|:  ...|:||:|.||||||..||:....:|:|.|||||||||||||||||||||||||||
 Frog   609 LPVAKLFTAGPISRQSSLSSDSGGGSVREQHGLQQVPADRRKSQMEEVQDELIHRLTIGRSAAQK 673

Human   728 KFHVPRQNVPVINITYDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGAR 792
            ||.|||.|.|.::|:|.|..||||:|||:||||.|||:|||||.|||||||.||||:||||||.|
 Frog   674 KFTVPRLNAPAVHISYSSPAEDVKSWLQAKGFNSVTVDSLGVLTGAQLFSLTKDELKTVCPEGPR 738

Human   793 VYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAASDSGVESFDEGSSH 842
            ||:|:||||||:|:.||.|||.|||::|||:|:.|||||||||||||:||
 Frog   739 VYNQVTVQKAAIEEQSGGSELLEIMKKRQERINMAASDSGVESFDEGNSH 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPS8	XP_047284450.1	PTB_EPS8	84..211	CDD:269921	96/126 (76%)
		SH3_Eps8	555..608	CDD:212698	40/52 (77%)
		SAM_EPS8-like	740..804	CDD:188939	48/63 (76%)
eps8	NP_001072508.1	PTB_EPS8	58..188	CDD:269921	97/129 (75%)
		SH3_Eps8	498..551	CDD:212698	40/52 (77%)
		SAM_EPS8-like	686..750	CDD:188939	48/63 (76%)