Protein Alignment EPS8 and Eps8

DIOPT Version :10

• Sequence 1: XP_047284450.1
• Gene: EPS8 / 2059
• HGNCID: 3420
• Length: 842
• Species: Homo sapiens
• Sequence 2: NP_001363864.1
• Gene: Eps8 / 312812
• RGDID: 1310590
• Length: 822
• Species: Rattus norvegicus
• Alignment Length: 822
• Identity: 743/822 - (90%)
• Similarity: 784/822 - (95%)
• Gaps: 0/822 - (0%)

Human    21 MNGHISNHPSSFGMYPSQMNGYGSSPTFSQTDREHGSKTSAKALYEQRKNYARDSVSSVSDISQY 85
            ||||:|||.|.:|:||||||||||||.:||.||||.|:|||||||||||||||||||||||:|||
  Rat     1 MNGHMSNHSSGYGIYPSQMNGYGSSPPYSQMDREHCSRTSAKALYEQRKNYARDSVSSVSDVSQY 65

Human    86 RVEHLTTFVLDRKDAMITVDDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPL 150
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 RVEHLTTFVLDRKDAMITVDDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPL 130

Human   151 NTIQHCQAVMHSCSYDSVLALVCKEPTQNKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRR 215
            |||||||||.|:|||||:|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 NTIQHCQAVAHTCSYDSILALVCKEPTQNKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRR 195

Human   216 PDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPE 280
            |:|||||:.|||.||||||||||.|||||||||||||||||||||||||||||||||||||||||
  Rat   196 PEALRMIAKADPGIPPPPRAPAPVPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPE 260

Human   281 MMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPP 345
            ||||||||||||||||||||||||||||||||||||||||||:||.|||||||||||||||||||
  Rat   261 MMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKSKKSKRKGPGEGVLTLRAKPPPP 325

Human   346 DEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVVQATGGPELASSVLSPLLNKDT 410
            |||:|||||||||||||||||||||||||:|||||||||||||||||||||||||||||||.|||
  Rat   326 DEFVDCFQKFKHGFNLLAKLKSHIQNPSASDLVHFLFTPLNMVVQATGGPELASSVLSPLLTKDT 390

Human   411 IDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATMEQDLYQ 475
            :|||||||..:|||||||||.||||.|||||||||||||||||||||||||||||||..|||:||
  Rat   391 VDFLNYTVKAEERQLWMSLGETWMKVRAEWPKEQFIPPYVPRFRNGWEPPMLNFMGAPTEQDMYQ 455

Human   476 LAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRH 540
            |||||||.||.||||:.||.||||||:|:|.|||||.||:::|.||.|:||||||:|.|.|.|||
  Rat   456 LAESVANAAEQQRKQDSKRQSTEHSSMSDYPPADGYTFSNSMYHRGPHVDQGEAALALKSTPNRH 520

Human   541 IDRNYEPLKTQPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNIL 605
            :||||:|:||||||||||||||||||:|||||:|||:||||||||||||||||||||||||||||
  Rat   521 VDRNYDPVKTQPKKYAKSKYDFVARNSSELSVMKDDVLEILDDRKQWWKVRNASGDSGFVPNNIL 585

Human   606 DIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPTPAPVPVPLPPSTPAPVPVSKV 670
            ||:|.||||:||.||||||||||||.|||||.||||.||||||||||||||||||.||||||.||
  Rat   586 DIMRTPESGVGRTDPPYTHTIQKQRTEYGPRSADTPSAPSPPPTPAPVPVPLPPSAPAPVPVPKV 650

Human   671 PANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEEVQDELIHRLTIGRSAAQKKFHVPRQN 735
            |||:||||||||:|||||.|||||:|||||||||||||||||||..||||||||||:||||||||
  Rat   651 PANVTRQNSSSSESGGSIARDSQRYKQLPVDRRKSQMEEVQDELFQRLTIGRSAAQRKFHVPRQN 715

Human   736 VPVINITYDSTPEDVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRTVCPEGARVYSQITVQ 800
            ||||||||||:||:|||||||||||||||:|||||||||||||||||||:||||||||:||||||
  Rat   716 VPVINITYDSSPEEVKTWLQSKGFNPVTVSSLGVLNGAQLFSLNKDELRSVCPEGARVFSQITVQ 780

Human   801 KAALEDSSGSSELQEIMRRRQEKISAAASDSGVESFDEGSSH 842
            ||||||||||||||||||||||||||||||||||||||||||
  Rat   781 KAALEDSSGSSELQEIMRRRQEKISAAASDSGVESFDEGSSH 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPS8	XP_047284450.1	PTB_EPS8	84..211	CDD:269921	123/126 (98%)
		SH3_Eps8	555..608	CDD:212698	49/52 (94%)
		SAM_EPS8-like	740..804	CDD:188939	58/63 (92%)
Eps8	NP_001363864.1	PTB_EPS8	64..191	CDD:269921	123/126 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..224		16/19 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..320		22/24 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	460..487		19/26 (73%)
		SH3_Eps8	535..588	CDD:212698	49/52 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..685		67/76 (88%)
		Effector region. /evidence=ECO:0000250	649..822		160/172 (93%)
		Amphipathic helix. /evidence=ECO:0000250	680..698		15/17 (88%)
		Helix bundle 1. /evidence=ECO:0000250	718..738		17/19 (89%)
		SAM_EPS8-like	720..784	CDD:188939	58/63 (92%)
		Helix bundle 2. /evidence=ECO:0000250	752..757		4/4 (100%)
		Helix bundle 3. /evidence=ECO:0000250	762..767		3/4 (75%)
		Helix bundle 4. /evidence=ECO:0000250	766..785		17/18 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..822		34/34 (100%)