Protein Alignment EPS8 and eps-8

DIOPT Version :10

• Sequence 1: XP_047284450.1
• Gene: EPS8 / 2059
• HGNCID: 3420
• Length: 842
• Species: Homo sapiens
• Sequence 2: NP_001360610.1
• Gene: eps-8 / 178411
• WormBaseID: WBGene00001330
• Length: 943
• Species: Caenorhabditis elegans
• Alignment Length: 995
• Identity: 262/995 - (26%)
• Similarity: 402/995 - (40%)
• Gaps: 257/995 - (25%)

Human     8 SVP-GIPNTQVKDTMNGHISNHPSSFGMYPSQMNGYGSSPTFSQTDREHGSKTSAKALYEQRKNY 71
            |.| |.|......:.....|:||....|         |.|...::|...||:...     .|.::
 Worm    30 STPGGQPAPSPSHSQQSASSHHPRGVPM---------SQPIARRSDYRTGSEQMT-----PRSDH 80

Human    72 ARDSV---------SSVSDIS-QYRVEHLTTFVLDRKDAMITVDDGIRKLKLLDAKGKVWTQDMI 126
            ...|:         ..|.|:: .|.||||.||.:.|:..:....|||||||.::....:|.|.:|
 Worm    81 RGPSMGYGNGGSVDQRVDDVTPSYYVEHLATFAVGRQFGLTFPADGIRKLKQMEKNSAIWAQPLI 145

Human   127 LQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCS---YDSVLALVCKE-------PTQNKP 181
            |:....||::.| ::...:|.|||..|:...|.:.:.|   |::||..|.:|       ||
 Worm   146 LRFRHNAVTVED-DNGELVEQFPLELIEQPTAHVSNDSRETYNNVLLFVVREDRKRMSTPT---- 205

Human   182 DLHLFQCDEVKANLISEDIESAISDS----KGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPG 242
            ::|:|||..|.|..::||:::.:...    :.|::...|..|:......|..||
 Worm   206 EMHIFQCIRVSATDVAEDLKNYVQGQFRRVRNGRRTAAPTHLQAQQQQMPFYPP----------- 259

Human   243 TVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKL 307
                               |....        ..||.||    .:|||..||...||||.|:.::
 Worm   260 -------------------DDASI--------SSETSEM----FERDVNTLNRCFDDIERFVARI 293

Human   308 QKAAEAFSELSKR--------KKNKKGKRKGPGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAK 364
            |.||.|..|:.::        :::||.::.....|:|.:||:.|...||:|..:|||..||||||
 Worm   294 QSAALAQREIEQQNHRYRTANRRDKKNQQPPDPNGILFMRAQLPLESEFVDILKKFKLSFNLLAK 358

Human   365 LKSHIQNPSAADLVHFLFTPLNMVVQATG---GPELASSVLSPLLNKDTIDFLNYTVNGDERQLW 426
            ||:||..|:|.:|:|||||||.::::|..   |..:|.:|.||||:.:..:.:...:...|..:|
 Worm   359 LKNHIHEPNAPELLHFLFTPLAVILEACHWGLGRNVAPTVASPLLSLEARELMQNCLTSHESDIW 423

Human   427 MSLGGTWMKARAEWPKEQFIPPYVPRFRNGW----------------------------EPP--- 460
            ||||..|.....:|.| ...|||.|.|.:|:                            :||
 Worm   424 MSLGEAWRTPPEDWTK-PLPPPYRPIFNDGFAPYGVADRAMATPNQIHRGHSAPPEHFRQPPPRE 487

Human   461 ------------------------------MLNFMGATMEQDLYQLAESVANVAE------HQRK 489
                                          .|.|...|:|::  :|....|.:.|      |:.|
 Worm   488 RNMVDTAPNTPQSMQRTPKSRPPHRNMSVDNLEFDRLTLERE--RLEFEKAKIMERESRLRHEEK 550

Human   490 Q---EIKRLSTEHSSVSE--YHPADGYAFSSNIYTRGSHLDQGEAAVAFKPTSNRHIDRNYEPLK 549
            |   |.:|:..|...:::  ..|....|   .:.|......:.:..::..|...|:   ||..:|
 Worm   551 QIEDEKRRMHAEKDLITKETTQPVPPPA---AVVTHQPITKRYDPPISISPPPQRN---NYSHVK 609

Human   550 ------TQPK-------------KYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWKVRNASG 595
                  |.|:             |.|...||...:|..||:|.|.:.||::.|.:.||:.:|...
 Worm   610 VTVDSDTSPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFDERNWWECKNMHQ 674

Human   596 DSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYG----PRPADTPPAPSPPP-------- 648
            ..|:||:.||.:|  |......|.|.: |........|.    ..||.....|.|||
 Worm   675 RVGYVPHTILSMV--PFEQQQYASPNH-HNNSSSTGGYNNGHHQGPAQNVYRPPPPPLVSDAGVQ 736

Human   649 --------TPAPVPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKS 705
                    .|.|.||.:|| .|.||....:...:..|.           :..|:.::.||:....
 Worm   737 VEIRREHVAPPPPPVVIPP-PPPPVRTPTMEELLRMQQ-----------QQQQKQRKPPVEEPVY 789

Human   706 QMEEVQ------------DELIHRLTIGRSAAQKKFHVPR---QNVPVINITYDSTPEDVKTWLQ 755
            |.:..|            .:||..:|  .:..|....:.|   |....:.|...|:||||..|||
 Worm   790 QPQPAQRAGLEIWRRNQNPQLIQEVT--ETVGQHSGDILRPAMQRATRVAINEKSSPEDVTRWLQ 852

Human   756 SKGFNPVTVNSLGVLNGAQLFSLNKDELRTVC--PEGARVYSQITVQK--AALEDSSGSSELQEI 816
            .|||:|..::.|...:||.||||:|..|:..|  .||..:|||:.|||  :.....:| .||:.|
 Worm   853 EKGFSPRVIDLLDGQDGANLFSLSKLHLQQACGRDEGGYLYSQLLVQKKRSGFRTHTG-DELKAI 916

Human   817 MRRRQ---EKISAAASDSGV 833
            :..|:   |..:.||:|..|
 Worm   917 LNHRRTHVELSNEAAADEPV 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPS8	XP_047284450.1	PTB_EPS8	84..211	CDD:269921	44/140 (31%)
		SH3_Eps8	555..608	CDD:212698	19/52 (37%)
		SAM_EPS8-like	740..804	CDD:188939	31/67 (46%)
eps-8	NP_001360610.1	PTB_EPS8	100..231	CDD:269921	44/135 (33%)
		CAF-1_p150	<528..575	CDD:402959	10/48 (21%)
		SH3_Eps8	634..687	CDD:212698	19/52 (37%)
		SAM_3	836..897	CDD:436214	28/60 (47%)