DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smarcb1 and Snr1

DIOPT Version :9

Sequence 1:	NP_035548.1	Gene:	Smarcb1 / 20587	MGIID:	1328366	Length:	385	Species:	Mus musculus
Sequence 2:	NP_730935.1	Gene:	Snr1 / 40657	FlyBaseID:	FBgn0011715	Length:	370	Species:	Drosophila melanogaster

Alignment Length:	386	Identity:	254/386 - (65%)
Similarity:	301/386 - (77%)	Gaps:	20/386 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 MALSKTFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIV---A 65
            ||| :|:|.|||.||||:.||:|.:|||||||:|.|||.|||:||.:.|.:.:.||||::.   .
  Fly     1 MAL-QTYGDKPVAFQLEEGGEYYYVGSEVGNYMRHFRGILYKKYPGMTRIVLSNEERKRLAESGL 64

Mouse    66 SSHGKKTKPNTKDHGYTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYLREQKAKRNSQ 130
            |||              .||:||:||:|.||::|:.||||||:|||::|......||.|:|:..|
  Fly    65 SSH--------------ILASSVSLLRAVEVDDIMAGNDEKYRAVSVNTSDTPVPRESKSKKQPQ 115

Mouse   131 WVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENASQPEVLVPIRLDMEI 195
            :|||:|||| ||||||.:|.|||||:...|.||||:||||.||....|||:|.|.|||||||||:
  Fly   116 YVPTMPNSS-HLDAVPQATPINRNRVHTKKVRTFPMCFDDTDPTASLENAAQKECLVPIRLDMEL 179

Mouse   196 DGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTD-SILEDQSD 259
            :||||||.||||.||.::|||.|:|:||||||||||.||||||.|||||||::|.| .|||:..|
  Fly   180 EGQKLRDTFTWNKNESMITPEQFAEVLCDDLDLNPLPFVPAIAQAIRQQIEAFPNDPPILEETCD 244

Mouse   260 QRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIRGQLSWHQK 324
            ||||:||||||||.|||||.|||||||.|:||:||:|||:||||||||||.||||||||||||.:
  Fly   245 QRVIVKLNIHVGNTSLVDQVEWDMSEKNNNPEEFAIKLCAELGLGGEFVTAIAYSIRGQLSWHCR 309

Mouse   325 TYAFSENPLPTVEIAIRNTGDADQWCPLLETLTDAEMEKKIRDQDRNTRRMRRLANTAPAW 385
            ||||||.||.|:::..||..|||.|.|.|||||||||||||||||||||||||||||...|
  Fly   310 TYAFSEAPLSTIDVPFRNPSDADAWAPFLETLTDAEMEKKIRDQDRNTRRMRRLANTTTGW 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smarcb1	NP_035548.1	DNA-binding. /evidence=ECO:0000250\|UniProtKB:Q12824	1..113		58/111 (52%)
		WH_NTD_SMARCB1	9..107	CDD:411036	50/100 (50%)
		SNF5	181..363	CDD:398495	136/182 (75%)
		2 X approximate tandem repeats	186..319		104/133 (78%)
		MYC-binding. /evidence=ECO:0000250\|UniProtKB:Q12824	186..245		46/58 (79%)
		Interaction with PPP1R15A. /evidence=ECO:0000250\|UniProtKB:Q12824	304..318		12/13 (92%)
Snr1	NP_730935.1	WH_NTD_SMARCB1	5..92	CDD:411036	50/100 (50%)
Snr1	NP_730935.1	SNF5	165..348	CDD:398495	136/182 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844417
Domainoid	1	1.000	196	1.000	Domainoid score	I3134
eggNOG	1	0.900	-	-		E1_KOG1649
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2310
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1343
Isobase	1	0.950	-	0	Normalized mean entropy	S1514
OMA	1	1.010	-	-		QHG45849
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002902
OrthoInspector	1	1.000	-	-		oto93018
orthoMCL	1	0.900	-	-		OOG6_103095
Panther	1	1.100	-	-	LDO	PTHR10019
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1364
SonicParanoid	1	1.000	-	-		X1914
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740