| Sequence 1: | NP_004437.2 | Gene: | EPRS1 / 2058 | HGNCID: | 3418 | Length: | 1512 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_524471.2 | Gene: | GluProRS / 42834 | FlyBaseID: | FBgn0005674 | Length: | 1714 | Species: | Drosophila melanogaster |
| Alignment Length: | 1728 | Identity: | 873/1728 - (50%) |
|---|---|---|---|
| Similarity: | 1097/1728 - (63%) | Gaps: | 233/1728 - (13%) |
- Green bases have known domain annotations that are detailed below.
|
Human 3 TLSLTVNSGDPPLGALLAVEHVKDDVSISVEEGKENI-LHVSEN--VIFTDVNSILRYLARVATT 64
Human 65 AGLYGSNLMEHTEIDHWLEFSATKLSSC-DSFTSTINELNHCLSLRTYLVGNSLSLADLCVWATL 128
Human 129 KGNAAWQEQLKQKKAPVHVKRWFGFLEAQQAFQSV--------GTKWDVSTTKARV---APEKKQ 182
Human 183 DVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKED 247
Human 248 FEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRIDSKHR 312
Human 313 KNPIEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYPTY 377
Human 378 DFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFV 442
Human 443 NEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRY 507
Human 508 VALLKKEVIPVNVPEAQEEMKEVAKHPKNPEVGLKPVWYSPKVFIEGADAETFSEGEMVTFINWG 572
Human 573 NLNITKIHKNADGKIISLDAKLNLENKDYKKTTKVTWLA--ETTHALPIPVICVTYEHLITKPVL 635
Human 636 GKDEDFKQYVNKNSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCVLI 700
Human 701 YIPDGHTKEMPTSGSK-EKTKVEATKNETS----------------------------------- 729
Human 730 -----------APFK---------------ERPTPSLNNNCTTSEDSLVLYNRVAVQGDVVRELK 768
Human 769 AKKAPKEDVDAAVKQLLSLKAEYKEKTGQEYKPGNPPAEIGQNISSNSSASILES-KSLYDEVAA 832
Human 833 QGEVVRKLKAEKSPKAKINEAVECLLSLKAQYKEKTGKEYIPG---QPPLSQSSDSSPTRNSEPA 894
Human 895 GLETPEAKVLFDKVASQGEVVRKLKTEKAPKDQVDIAVQELLQLKAQYKSLIGVEYKP------- 952
Human 953 -----VSATGAE----------------DKDKK-KKEK--------------------------- 968
Human 969 ---ENKSEKQNKPQKQNDGQRKDPSKNQ------------------------------------- 993
Human 994 -------------------GGGLSSSGAGEGQ-----------------GPKKQTRLGLEAKKEE 1022
Human 1023 NLADWYSQVITKSEMIEYHDISGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSAL 1087
Human 1088 EKEKTHVADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVR 1152
Human 1153 WEFKHPQPFLRTREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEELLAIPVVKGRKTEKEKFA 1217
Human 1218 GGDYTTTIEAFISASGRAIQGGTSHHLGQNFSKMFEIVFEDPKIPGEKQFAYQNSWGLTTRTIGV 1282
Human 1283 MTMVHGDNMGLVLPPRVACVQVVIIPCGITNALSEEDKEALIAKCNDYRRRLLSVNIRVRADLRD 1347
Human 1348 NYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAENEAETKLQAILEDIQVTL 1412
Human 1413 FTRASEDLKTHMVVANTMEDFQKILDSGKIVQIPFCGEIDCEDWIKKTTARDQDLEPGAPSMGAK 1477
Human 1478 SLCIPFKPLCELQPGAKCV---CGKNPAKYYTLFGRSY 1512 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| EPRS1 | NP_004437.2 | PLN02907 | 13..711 | CDD:215492 | 411/714 (58%) |
| GST_C_GluProRS_N | 74..157 | CDD:198342 | 29/83 (35%) | ||
| Glutamate--tRNA ligase | 164..759 | 374/661 (57%) | |||
| tRNA-synt_1c | 197..502 | CDD:279135 | 230/304 (76%) | ||
| 'HIGH' region | 204..214 | 9/9 (100%) | |||
| 'KMSKS' region | 432..436 | 3/3 (100%) | |||
| tRNA-synt_1c_C | 504..681 | CDD:281883 | 97/178 (54%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 709..744 | 13/96 (14%) | |||
| WHEP-TRS | 753..805 | CDD:278865 | 29/51 (57%) | ||
| 3 X 57 AA approximate repeats | 760..956 | 86/211 (41%) | |||
| WHEP-TRS | 826..878 | CDD:278865 | 24/54 (44%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 869..900 | 8/33 (24%) | |||
| WEPRS_RNA | 904..952 | CDD:238473 | 22/47 (47%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 956..1012 | 20/175 (11%) | |||
| Charged | 959..991 | 10/78 (13%) | |||
| Proline--tRNA ligase | 1007..1512 | 340/507 (67%) | |||
| PRK08661 | 1019..1512 | CDD:236327 | 330/495 (67%) | ||
| ProRS_core_arch_euk | 1023..1286 | CDD:238401 | 211/262 (81%) | ||
| L-proline binding. /evidence=ECO:0000269|PubMed:24100331, ECO:0007744|PDB:4K87 | 1121..1123 | 1/1 (100%) | |||
| ProRS_anticodon_zinc | 1292..1512 | CDD:238439 | 112/222 (50%) | ||
| GluProRS | NP_524471.2 | PLN02907 | 1..715 | CDD:215492 | 411/721 (57%) |
| GST_C_GluProRS_N | 76..153 | CDD:198342 | 29/83 (35%) | ||
| tRNA-synt_1c | 203..508 | CDD:279135 | 230/304 (76%) | ||
| tRNA-synt_1c_C | 510..688 | CDD:281883 | 97/178 (54%) | ||
| WHEP-TRS | 748..799 | CDD:278865 | 2/50 (4%) | ||
| WHEP-TRS | 821..870 | CDD:278865 | 28/48 (58%) | ||
| WHEP-TRS | 894..945 | CDD:278865 | 24/50 (48%) | ||
| WEPRS_RNA | 973..1022 | CDD:238473 | 23/48 (48%) | ||
| WHEP-TRS | 1050..1100 | CDD:278865 | 6/49 (12%) | ||
| WHEP-TRS | 1122..1168 | CDD:278865 | 0/45 (0%) | ||
| PRK08661 | 1220..1714 | CDD:236327 | 330/495 (67%) | ||
| ProRS_core_arch_euk | 1224..1486 | CDD:238401 | 211/262 (81%) | ||
| ProRS_anticodon_zinc | 1492..1714 | CDD:238439 | 112/222 (50%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165160101 | |
| Domainoid | 1 | 1.000 | 497 | 1.000 | Domainoid score | I353 |
| eggNOG | 1 | 0.900 | - | - | E1_COG0008 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 956 | 1.000 | Inparanoid score | I334 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S1284 |
| OMA | 1 | 1.010 | - | - | QHG52536 | |
| OrthoDB | 1 | 1.010 | - | - | D111937at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0002386 | |
| OrthoInspector | 1 | 1.000 | - | - | oto89463 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_100749 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR43382 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R1877 |
| SonicParanoid | 1 | 1.000 | - | - | X1809 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 15.750 | |||||