DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc6a2 and List

DIOPT Version :9

Sequence 1:	NP_033235.3	Gene:	Slc6a2 / 20538	MGIID:	1270850	Length:	617	Species:	Mus musculus
Sequence 2:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	202/555 - (36%)
Similarity:	306/555 - (55%)	Gaps:	19/555 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse    48 SQDSDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYM 112
            |:....:|.|.||..::||.|.:..:|.|.|:|||||:.::||||.|:|||.:.|::.|.|::|:
  Fly    10 SEKPAEKPAEQWGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYL 74

Mouse   113 ELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCG 177
            |::|||:...|....:.:.|..|||....:|.......||:.|:|.:|.:..|||...|||:.|.
  Fly    75 EISLGQFTGRGVVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRCW 139

Mouse   178 HSWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGI-HDIGLPQWQLLLCL 241
            .||.: :|.|....|:|          .|.:||..::||.:  |||...| :.:.||.|||:.||
  Fly   140 ESWGT-DCHDGNAQNSS----------GKMSPAQLYFEREI--LHEVPNIDNGLSLPNWQLVACL 191

Mouse   242 MVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEAT 306
            .:..:|:...|.:|:|:|||..:.....||.||.:||:..||||||.:||..:....:..|....
  Fly   192 AIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYFFKPQWRELLNPL 256

Mouse   307 VWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHE 371
            ||..|.||:||||...||.||.:||||.|:.|.|.|.::.:|::..:|.|:|...|.|||.:|.|
  Fly   257 VWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIAGCITFGILGNLARE 321

Mouse   372 -HKVNIEDVATEGAGLVFILYPEAISTLS-GSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADD 434
             ...:|..|...||||.||.|||||:... ....:||||||||..||:.|::|....::..:.|.
  Fly   322 TGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGSTVGMGSCILRVIRDQ 386

Mouse   435 FQVLKRHRKLFTCVVTISTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVD 499
            |.:...........:|:..|.:::..:|.||.::|.|:|.:....:.|...:.|.:.|:|.|||:
  Fly   387 FGLRSPPIWKLASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFTALILAIGELVAVAWIYGVN 451

Mouse   500 RFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYTYPPWANWVGWGIALS 564
            ||..||:.|||.:.|.||||||:|::|..:..|::..:::...|.|....||..|:..|..:|..
  Fly   452 RFCEDIKFMMGIETGWYWRLCWRFITPGLMTAVLIYMLLDMSALEYKGVGYPTLAHVFGCFLATL 516

Mouse   565 SMILVPA---YVIYKFLSIRGSLWERVAYGITPEN 596
            .:|.:|.   |.|||.....||.|:|:.....|.:
  Fly   517 GLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSD 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a2	NP_033235.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
Slc6a2	NP_033235.3	SLC5-6-like_sbd	56..615	CDD:382020	200/547 (37%)
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	182/482 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820