DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc6a2 and CG15279

DIOPT Version :9

Sequence 1:	NP_033235.3	Gene:	Slc6a2 / 20538	MGIID:	1270850	Length:	617	Species:	Mus musculus
Sequence 2:	NP_609726.1	Gene:	CG15279 / 34863	FlyBaseID:	FBgn0028886	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	202/571 - (35%)
Similarity:	320/571 - (56%)	Gaps:	32/571 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse    48 SQDSDA----QPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMP 108
            |.|.:|    :.|.||||.::||:|.:..:|.|.||||||:....||||||||||.:.|.:.|.|
  Fly    38 SDDQEAAKVPEERATWGKGVEFLMSCIAMSVGLGNVWRFPFTALDNGGGAFLIPYLIVLFLIGKP 102

Mouse   109 LFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPW 173
            ::|:|:.:||::..|:..|:.:||..||||.........:..||..::|....|...||...|||
  Fly   103 IYYLEMVIGQFSSRGSVKVFDLCPAMKGVGAGQAFQVFMLSTYYAALVAIIGRYFIESFRNPLPW 167

Mouse   174 TNCGHSWNSPNCTD--PKLLNASVL-------GDHTKYSKYK--FTPAAEFYERGVLHLHESSGI 227
            :.|...|.. :|.:  |...|.|.|       .::|..|:..  .|.:..::.:.|  |||...|
  Fly   168 STCRAEWGI-HCINSAPDASNWSQLESNDQRPQNYTMKSQNDRVITSSEWYFVKEV--LHEKPNI 229

Mouse   228 HD-IGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGI 291
            .: ||||.|:|::.|.:....::|.:.:|||:|||..:..|..||.::.||||..|||||:.:||
  Fly   230 EEGIGLPNWELVIGLFIAWSCVFFIIRRGVKSSGKASYFLALFPYVIMGVLLVRAVTLPGSIDGI 294

Mouse   292 NAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFI 356
            ..::...:.::.:..||..|.||.|:||...||.:|.::|:|||.:|.:|||.:.:.::.:||.:
  Fly   295 YYFIKPQWGKILDPKVWYAAVTQCFYSLSVCFGNIIMYSSFNKFGHNVHRDAAIVTGLDTMTSLL 359

Mouse   357 SGFAIFSILGYMAHEHKVNIEDVAT---EGAGLVFILYPEAISTLSG-STFWAVLFFLMLLALGL 417
            :||.||.|||::|||  :..:|:.:   .||||.||.||:||:.... ...::|||||||..||:
  Fly   360 AGFTIFGILGHLAHE--IGTDDIGSVVKGGAGLAFISYPDAIAKFKNLPQIFSVLFFLMLFVLGI 422

Mouse   418 DSSMGGMEAVITGLADDFQVLKRHRKLFTC--VVTISTFLLALFCITKGGIYVLTLLDTFAAGTS 480
            .|::......:|.:.|.|....:    :.|  ::.:.:|.:.|..||.||.|:|||:|.|.|...
  Fly   423 GSNIAMTSCSVTAIRDRFPNFGQ----WQCSLLIAVVSFFIGLMYITPGGQYMLTLVDFFGASMI 483

Mouse   481 ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTY 545
            .|...:.|...:.|.||.||...||:.|:|.|.||||||||..::|..:..:::.....::||||
  Fly   484 ALVLGIAELYTIGWIYGTDRLCKDIEFMLGRKVGLYWRLCWSIITPLIMTVILIYFYATYQPLTY 548

Mouse   546 DDYTYPPWANWVGWGIALSSMILVPAYVIYKFLSIRG-SLWERVAYGITPE 595
            ::..||.|:..:||.|....::.:|.::|...:...| :|..::....||:
  Fly   549 NNIVYPNWSYSIGWLITAFGILQLPIWMIVAIVRDPGQTLGAKIRGAFTPK 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a2	NP_033235.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
Slc6a2	NP_033235.3	SLC5-6-like_sbd	56..615	CDD:382020	199/559 (36%)
CG15279	NP_609726.1	SLC5-6-like_sbd	50..598	CDD:294310	197/556 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820