DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc5a1 and CG2187

DIOPT Version :9

Sequence 1:	NP_062784.3	Gene:	Slc5a1 / 20537	MGIID:	107678	Length:	665	Species:	Mus musculus
Sequence 2:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	133/530 - (25%)
Similarity:	217/530 - (40%)	Gaps:	84/530 - (15%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 SSTLSPAVTATDAPIPSYERIR-NAADISVIVIYFVVVMAVGLW-AMFSTNRGTVGGFFLAGRSM 65
            |:|.:...|...|...:.:.:| ...|..|.||.......:|:: ..||.::.|...:...|:.|
  Fly     2 STTTTTTTTMASAVSSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKM 66

Mouse    66 VWWPIGASLFASNIGSGHFVGLAGTGAAAGIAMGGFEW-----NALVLVVVLGWIFVPIYIKAGV 125
            ...||..||.||.:.     |:|.....|.....||.:     ..||::.:|.:|.||::.:..|
  Fly    67 QTLPIAISLVASQLS-----GIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNV 126

Mouse   126 VTMPEYLRKRFGGKRIQIYL------SVLSLLLYIFTKISADIFSGAIFINLALGLDIYLAIFIL 184
            ....|||..||..:..|:..      |.|.|.:|:|....|       |..:. |::|:|...::
  Fly   127 SNCYEYLEMRFNKRTRQLVTFFFVTNSFLMLPVYMFIPSLA-------FAQVT-GMNIHLINVMV 183

Mouse   185 LAITALYTITGGLAAVIYTDTLQTAIMLVGSFILTGFAFNEVGGYEAFMDKYMKAIPTKVSNGNF 249
            .:|...||:.||:.||::||.:|.||||: |.:..|                  .:.|..|.|.|
  Fly   184 SSICIFYTMLGGIKAVVWTDVVQGAIMLL-SVVAVG------------------VLGTIRSGGMF 229

Mouse   250 TAKEECYTPRADSFHIFRDP----------ITGDMPWPGLIFGLAILALWYWCTDQVIVQRCLSA 304
            |..|........:|....||          :.|...|.|.| ||          :|..|||.:|.
  Fly   230 TVMERASDGGRFNFDFGLDPRIRMTFWGATMGGIFMWTGHI-GL----------NQSCVQRIVSL 283

Mouse   305 KNMSHVKAGCTLCGYLKLLPMFLMVMPGMISRILYTEKIACVLPEECQKYCGTPVGCTNIAYPTL 369
            .:.||.|....:.|...|:..|...:.|:|....|         ..|.......|...:...|..
  Fly   284 PSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARY---------YGCDPMLAGLVSKPDKMMPFF 339

Mouse   370 VVELMPN--GLRGLMLSVMMASLMSSLTSIFNSASTLFTMDIYTKIRKKASEKELMIAGRLFILV 432
            |.::|.:  |:.|:.:|.:.::.:|||::..||.:.:...| |.|.|.:.:|.....|.:|.::|
  Fly   340 VQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFD-YIKPRIRHTEARANWAMKLIVVV 403

Mouse   433 LIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEQGAFWGLILGFLIGI 497
            :.|..|....:||:..|  :...:.:||......:..||||.:|..|.|.:.|    :...::.:
  Fly   404 MGGYCILGGFMVQNFNS--ILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTA----VTSIIVSV 462

Mouse   498 SRMITEFAYG 507
            ..|:...|.|
  Fly   463 VAMVWIIANG 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a1	NP_062784.3	SLC5-6-like_sbd	27..665	CDD:294310	128/505 (25%)
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	128/505 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740