DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc2a4 and CG1213

DIOPT Version :9

Sequence 1:	NP_033230.2	Gene:	Slc2a4 / 20528	MGIID:	95758	Length:	509	Species:	Mus musculus
Sequence 2:	NP_001246937.1	Gene:	CG1213 / 40728	FlyBaseID:	FBgn0037387	Length:	491	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	150/490 - (30%)
Similarity:	226/490 - (46%)	Gaps:	67/490 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 PRQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGP--------GGPDSI 72
            |....:|.:.:|..:|.|.:...|..:|                |....||        ..|.|.
  Fly    34 PEPVKSGRIFMAAVAANLSAFVVGTTLG----------------WTSPIGPKLKSEDTSDSPLSR 82

Mouse    73 PQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEI 137
            |..:....|..|  :.:||.:::.|:.|.::..:|||..:|::::..||.   .||...|:...|
  Fly    83 PITSDEDAWISS--LIAVGALVAPFVAGPMADRIGRKWVLLSSSLFFVLA---FGLNMVASEVWI 142

Mouse   138 LILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLW 202
            |.:.|.:.|...|....:.|||||||:..::|||.|:|.||.||.|||....:| ..:...|..|
  Fly   143 LYMSRLIQGFGVGFVMTVQPMYVGEISTDNVRGATGSLMQLFIVGGILYVYAIG-PYVSYQALQW 206

Mouse   203 PLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGWA--DVSDALAELKD--E 263
                ...|:|.:..|:.. ..|||| |.:..:..:..|.|||:.|.|.:  .|.|.:||::.  |
  Fly   207 ----CCIVVPVVFDLVFY-MMPESP-YFFAGKGRKSEALKSLQFLRGQSAEGVHDEMAEIQANVE 265

Mouse   264 KRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVG-QPAYATI 327
            :....:...|.|.:..|   :|:.|.|...|...|||||||.|.:.|.|||.||..| .||.|||
  Fly   266 EAMASKGTVMDLFKNAG---NRRALFICAGLISFQQLSGINVVLFNSQSIFASANTGLDPAIATI 327

Mouse   328 GAGVVNTVFTLVSVLLVERAGRRTLHL-------LGLAGMCGCAILM-----TVALLLLERVPAM 380
            ..|.|....:.::.|:.:|.||:.:.|       :|||.: |....|     .::.::...|||:
  Fly   328 IIGCVQVGSSALTPLVADRLGRKVMLLTSSSVMSIGLAAL-GAFFYMQLVKGDISSVVWMPVPAL 391

Mouse   381 SYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAM 445
            ...:||...||        ||:||.::.|:|....:..|.:|...:.||..|:|.. |....||:
  Fly   392 IIYNIVYCTGF--------GPLPWAVLGEMFPANIKSVASSVVASTCWTLGFLVTF-FYPSLDAL 447

Mouse   446 GP-YVFLLFAVLLLGFFIFTFLKVPETRGRTFDQI 479
            |. |.|.||||.::..|.|....|.||:|.:..||
  Fly   448 GSYYAFWLFAVCMVVAFFFVLFVVMETKGLSLQQI 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc2a4	NP_033230.2	Interaction with SRFBP1. /evidence=ECO:0000250\|UniProtKB:P14672	7..13
		Sugar_tr	27..483	CDD:278511	148/479 (31%)
		MFS	78..447	CDD:119392	122/385 (32%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		5/5 (100%)
		Dileucine internalization motif. /evidence=ECO:0000255	489..490
CG1213	NP_001246937.1	SP	42..482	CDD:273317	146/480 (30%)
CG1213	NP_001246937.1	MFS	47..460	CDD:119392	139/453 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100060
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810