DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a5 and SLC22A

DIOPT Version :9

Sequence 1:	NP_035526.1	Gene:	Slc22a5 / 20520	MGIID:	1329012	Length:	557	Species:	Mus musculus
Sequence 2:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	158/568 - (27%)
Similarity:	277/568 - (48%)	Gaps:	71/568 - (12%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 DEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLV------------PHTVN 57
            |.:...||::|.||.:||.|:...::.:....::.||.|.|..|||.|            |||
  Fly    28 DAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRCSVEECDLPGSNYYEPHT-- 90

Mouse    58 LSSAWRNHSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLE-----QESCLDGW 117
                  |.|||   |:|:.: ..|.||..:.:..::       ..||:...:     :|:|
  Fly    91 ------NWSIP---KNGKDL-DSCNRYTNSELPQWN-------HSVDICSADHFTKNKEAC---- 134

Mouse   118 EYDKDVFLS---TIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRK------NVL 173
            .:::.||..   ||..::.:.|.|:||..:..::..:|...|..|.|.::||:||.      .:|
  Fly   135 AHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGIL 199

Mouse   174 FLTMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIF 238
            ...:|:      ::.||.::..|.|...|..|...:.|...||:|.|::....|::..:: :.:|
  Fly   200 GAVLGV------IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSV-ITVF 257

Mouse   239 YAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKI 303
            ||.|.::|.:.|....|||:||.....|.::..|.:|.:|||.|||:|||:.:.|:.|:|:||.:
  Fly   258 YAVGEVLLAMSAKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHV 322

Mouse   304 NGIVAPSTIFDP------SELQDLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLS 362
            |....|.::.|.      .:||..:.::..:...:     :|.:.......:.|:...:.|:|||
  Fly   323 NKRELPESVLDKLVLANRDKLQQSSESRFPIREAF-----KNFKWRIANCSLCWIVHVLVYYGLS 382

Mouse   363 LDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYL 427
            |:...|.||.|.|...:|.||:|.:.:..|::....||||:...:...|...:......::...|
  Fly   383 LNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVL 447

Mouse   428 STALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPY 492
            ...|.:|||..||:::.::|.:.:|:|||.:||..:...|...|.||:|:|....|..|....|.
  Fly   448 QLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPLLAKYYANAPA 512

Mouse   493 ILMGSLTILTAILTLFFPESFGVPLPDTIDQMLRVKGIKQWQIQSQTR 540
            :|.....|::.:|||||||:..|.||.|:.:...: |:|:   ||:::
  Fly   513 MLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAI-GVKK---QSKSK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a5	NP_035526.1	2A0119	12..520	CDD:273328	151/539 (28%)
Slc22a5	NP_035526.1	MFS	123..510	CDD:119392	114/401 (28%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	151/539 (28%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	112/395 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.980