Protein Alignment EPHX1 and Jheh2

DIOPT Version :10

• Sequence 1: NP_000111.1
• Gene: EPHX1 / 2052
• HGNCID: 3401
• Length: 455
• Species: Homo sapiens
• Sequence 2: NP_611386.2
• Gene: Jheh2 / 37181
• FlyBaseID: FBgn0034405
• Length: 463
• Species: Drosophila melanogaster
• Alignment Length: 460
• Identity: 187/460 - (40%)
• Similarity: 269/460 - (58%)
• Gaps: 17/460 - (3%)

Human     1 MWLEILLTSV-----LGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI 60
            :|..||:.::     :|:..|..:|...:......:.:|||..:...||:.:|.||.:....|.|
  Fly     4 IWPRILVGALTILVAVGYKNYRDLSAPGKRPDLDNNAYWGPTLKEPYRENKAILPFDISVKPEVI 68

Human    61 HDLHQRIDK-FRFTPPLEDSCFHYGFNSNYLKKVISYWRNEF--DWKKQVEILNRYPHFKTKIEG 122
            .||..::.: .:...|||...|.||||:|.|.||:.|||:.:  .|.::.|.|.:..|::|:|:|
  Fly    69 EDLIGQLSRPLKAQAPLEGVGFQYGFNANELAKVVKYWRDTYLPKWSEREEYLKKLDHYQTEIQG 133

Human   123 LDIHFIHVKPPQLPAGHTPK---PLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPS 184
            |.|||||.||.|: .|..||   |||::|||||:..|||..|||||.|.:   ..::|||||.||
  Fly   134 LKIHFIHAKPSQV-KGQKPKKVLPLLLMHGWPGTVREFYDFIPLLTTPSD---KSDYVFEVIAPS 194

Human   185 IPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLN 249
            :||||:|:.|||.||.....|.:...||||:||.:|.:|||||||:|.:|:|.|.|.:|.|.|.|
  Fly   195 LPGYGWSQGSSKTGFGVAQVAVVMRNLMLRVGFDKFLVQGGDWGSIIGSNVASLFPENVLGYHSN 259

Human   250 MALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSAL 314
            |....|....|.::|...|..:  ..:.:....|.....:|.::|.|.||.|||.:||||:|:||
  Fly   260 MCGNNSPMGQLKMVLASFFPSW--FVDSEYADFYKGLGHLFSTIMEEMGYAHIQASKPDTIGNAL 322

Human   315 NDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLG 379
            .|:|.|||:||||||||||||.||.|.||||.::|:.|.||.|||:|:.|.:|.:|.|.|.|::.
  Fly   323 IDNPTGLASYILEKFSTWTNTAFRSLPDGGLTKRFTYDQLLDNVMIYYVTNSITTSMRLYSESMV 387

Human   380 QGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQD 444
            ........:.:.:....|.:.|..|:.|..:..:..|:|.|:..::...||||.|||.|:.|..|
  Fly   388 ASQFALAVDSVPIKAKAGCTRFAHEITHFSDSVLANKFPNLVHSTHHRDGGHFPAFELPQQLYDD 452

Human   445 IRKFL 449
            ...|:
  Fly   453 FVSFV 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHX1	NP_000111.1	EHN	48..157	CDD:461913	49/114 (43%)
		Abhydrolase_1	142..404	CDD:395444	120/264 (45%)
Jheh2	NP_611386.2	EHN	56..170	CDD:461913	49/114 (43%)
		Abhydrolase_1	156..370	CDD:395444	110/218 (50%)