Protein Alignment Slc22a3 and SLC22A

DIOPT Version :9

• Sequence 1: NP_035525.1
• Gene: Slc22a3 / 20519
• MGIID: 1333817
• Length: 551
• Species: Mus musculus
• Sequence 2: NP_649370.1
• Gene: SLC22A / 40437
• FlyBaseID: FBgn0037140
• Length: 568
• Species: Drosophila melanogaster
• Alignment Length: 565
• Identity: 174/565 - (30%)
• Similarity: 275/565 - (48%)
• Gaps: 78/565 - (13%)

Mouse     3 TFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCA--- 64
            |.|..|:..|:|||||..:|||:||..:..|...|..||             .|..:..||:
  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVF-------------TAATVTHRCSVEE 77

Mouse    65 --------WSPEEEWNLTTPELHVPAERRGQGHCHRYLLEATNTSSEL----------SCDPLTA 111
                    :.|...|:       :|...:....|:||      |:|||          |.|..|
  Fly    78 CDLPGSNYYEPHTNWS-------IPKNGKDLDSCNRY------TNSELPQWNHSVDICSADHFT- 128

Mouse   112 FPNRSAPLVSCS-GDWRYVETHSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYG 175
             .|:.|    |: .::.:.:...||.:.|.:.|.:.|.|.:...|.|||...|....|:.|||||
  Fly   129 -KNKEA----CAHNEFVFRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYG 188

Mouse   176 RLIIYLISCFGV--GITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVG 238
            |  .:.|:..|:  .:.||:.:|:|::..|::|.||..:.....:.|||||..|:||.|:|.:..
  Fly   189 R--SFSIALGGILGAVLGVIRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLAC 251

Mouse   239 IVIQMFFTLGIIILPGIAYFTPSWQGIQLAISL-PSFLFLLYYWVVPESPRWLITRKQGEKALQI 302
            .||.:|:.:|.::|...|.....|: |.|.|:. ||.:.|.|:|::|||.|||:::.:.|:|..|
  Fly   252 SVITVFYAVGEVLLAMSAKAFHDWR-ILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNI 315

Mouse   303 LRRVAKCNGKHL-SSNYSEITVTDEEVSNPSCLDLVRTP----------QMRKCTLILMFAWFTS 356
            |||.|..|.:.| .|...::.:.:.:....|...  |.|          ::..|:|    .|...
  Fly   316 LRRAAHVNKRELPESVLDKLVLANRDKLQQSSES--RFPIREAFKNFKWRIANCSL----CWIVH 374

Mouse   357 AVVYQGLVMRLGLIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAF 421
            .:||.||.:.:.|:.|:.|.:|....|||:||..:.||.::|.|||.......:.:|:.|:.|.|
  Fly   375 VLVYYGLSLNVVLLDGDKYNNFAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIF 439

Mouse   422 LPEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRL 486
            .....|.|:..:..:|:|.||.:|:::|...||:|||.|||..:|.||.:..||.::||.... |
  Fly   440 TGADQPVLQLVLFLVGKLTITASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAPQTPL-L 503

Mouse   487 AAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLG 531
            |..:...|.::|...|.|.|.|.:..|||..:.||.||::.:.:|
  Fly   504 AKYYANAPAMLFAGAAIVSGLLTLFFPETTNVVLPTTVQEADAIG 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	168/546 (31%)
		MFS	145..513	CDD:119392	125/381 (33%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	168/546 (31%)
		MFS	146..530	CDD:119392	129/393 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960