Protein Alignment Slc22a2 and Orct

DIOPT Version :10

• Sequence 1: NP_038695.1
• Gene: Slc22a2 / 20518
• MGIID: 1335072
• Length: 553
• Species: Mus musculus
• Sequence 2: NP_524479.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Alignment Length: 567
• Identity: 191/567 - (33%)
• Similarity: 297/567 - (52%)
• Gaps: 67/567 - (11%)

Mouse     5 DDILEHIGEFHLFQKQTFFLLAL---------LSGAFTPIYVGIVFLGFTPNHHCRSP----GVA 56
            ||::.|:|||..:||:.::||.|         |:|         |||...|:..|..|    .:.
  Fly     4 DDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAG---------VFLLAKPDFRCALPYENGSIY 59

Mouse    57 ELSQRCGWS---PAEELNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLDCVDPLSSLAANRSHLP 118
            |||... |:   |..|                  :|..|:||:.:..|:...|.||   |.:
  Fly    60 ELSPHL-WNLSYPENE------------------RCSYYDVDYTEEYLNGSIPRSS---NET--- 99

Mouse   119 LSPCEHGWVYDTPG--SSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKFCLL 181
             ..|. .:|||...  :|.|||:||||:.|.:.....||..:|..:|::..|.::|:.|||....
  Fly   100 -KTCS-SYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFF 162

Mouse   182 VTILINAISGVLMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQIAFT 246
            .::::..|.|||.|::|.|....:.|.:.|..:...:|:.|::..|.||..||...|:..|:.|:
  Fly   163 ASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFS 227

Mouse   247 VGLLILAGVAYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNG 311
            ||.::.||.||.:.:|||||.|:|||...||.|:|.||||.|||:.:.:..:|..||:..||:|.
  Fly   228 VGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENK 292

Mouse   312 KSVPVSLQSLTADEDTGMKLN---------PSFLDLVRTPQIRKHTLILMYNWFTSSVLYQGLIM 367
            ..||..:.....||....|..         .:..||:|.|.:|:.||::.::||.:|.:|.||..
  Fly   293 VEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSW 357

Mouse   368 HMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDLQWLK 432
            :....|.|..::|..|..||.|...:::.|::|.|||.....:.||||.:.||::|:|.|:.||.
  Fly   358 NTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLI 422

Mouse   433 ITVACLGRMGITIAYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPL 497
            :..|.:|::.||.:|..:.:.:||.:||.:||:.:...|.:..:|||:.|:|.. |.:||...||
  Fly   423 VACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPL 486

Mouse   498 VVFAVVGLVAGGLVLLLPETKGKALPETIEDAE---KMQRPRKKKEK 541
            ::...:.|.||.|.||||||..|.:||||||.|   |...|::..|:
  Fly   487 IICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQETAEE 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	179/539 (33%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15244	284..288		3/3 (100%)
Orct	NP_524479.1	2A0119	11..514	CDD:273328	179/539 (33%)