DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a2 and Orct

DIOPT Version :9

Sequence 1:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus
Sequence 2:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	191/567 - (33%)
Similarity:	297/567 - (52%)	Gaps:	67/567 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 DDILEHIGEFHLFQKQTFFLLAL---------LSGAFTPIYVGIVFLGFTPNHHCRSP----GVA 56
            ||::.|:|||..:||:.::||.|         |:|         |||...|:..|..|    .:.
  Fly     4 DDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAG---------VFLLAKPDFRCALPYENGSIY 59

Mouse    57 ELSQRCGWS---PAEELNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLDCVDPLSSLAANRSHLP 118
            |||... |:   |..|                  :|..|:||:.:..|:...|.||   |.:
  Fly    60 ELSPHL-WNLSYPENE------------------RCSYYDVDYTEEYLNGSIPRSS---NET--- 99

Mouse   119 LSPCEHGWVYDTPG--SSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKFCLL 181
             ..|. .:|||...  :|.|||:||||:.|.:.....||..:|..:|::..|.::|:.|||....
  Fly   100 -KTCS-SYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFF 162

Mouse   182 VTILINAISGVLMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQIAFT 246
            .::::..|.|||.|::|.|....:.|.:.|..:...:|:.|::..|.||..||...|:..|:.|:
  Fly   163 ASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFS 227

Mouse   247 VGLLILAGVAYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNG 311
            ||.::.||.||.:.:|||||.|:|||...||.|:|.||||.|||:.:.:..:|..||:..||:|.
  Fly   228 VGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENK 292

Mouse   312 KSVPVSLQSLTADEDTGMKLN---------PSFLDLVRTPQIRKHTLILMYNWFTSSVLYQGLIM 367
            ..||..:.....||....|..         .:..||:|.|.:|:.||::.::||.:|.:|.||..
  Fly   293 VEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSW 357

Mouse   368 HMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDLQWLK 432
            :....|.|..::|..|..||.|...:::.|::|.|||.....:.||||.:.||::|:|.|:.||.
  Fly   358 NTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLI 422

Mouse   433 ITVACLGRMGITIAYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPL 497
            :..|.:|::.||.:|..:.:.:||.:||.:||:.:...|.:..:|||:.|:|.. |.:||...||
  Fly   423 VACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPL 486

Mouse   498 VVFAVVGLVAGGLVLLLPETKGKALPETIEDAE---KMQRPRKKKEK 541
            ::...:.|.||.|.||||||..|.:||||||.|   |...|::..|:
  Fly   487 IICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQETAEE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	179/539 (33%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	131/377 (35%)
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	179/539 (33%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	123/356 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843591
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8821
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850