DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a2 and CG7333

DIOPT Version :9

Sequence 1:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus
Sequence 2:	NP_650814.2	Gene:	CG7333 / 42334	FlyBaseID:	FBgn0038715	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	152/581 - (26%)
Similarity:	239/581 - (41%)	Gaps:	94/581 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse     7 ILEHIGEFHLFQKQTFFLLALLSGAFTPI-----YVGIVFLGFTPNHHCRSPGVAELSQRCGWSP 66
            :|:..|.:..||     ::.||...:|.|     |.....:.|||.|.|....:..||
  Fly     6 VLDKCGNYGRFQ-----VMILLLYGYTNILGSLHYFSQTLITFTPEHWCFHADLNGLS------- 58

Mouse    67 AEELNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWVYDTP 131
                   |.|:.|..|....|.|        ...|..|:....::.||.      |.: |:::..
  Fly    59 -------VEGIRSVYENISASSC--------TPLLGVVNGTGVVSTNRK------CRN-WIFNRE 101

Mouse   132 G--SSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKFCLLVTILINAISGVLM 194
            .  .||.||...||..|....:.||...:|..:|.:..|||:|:.||...||:..|..|....:.
  Fly   102 SGYESITTELKWVCDKSHHPAVGQSFFFMGSVVGTIIFGYLSDQVGRLPSLLMATLCGATGDFIT 166

Mouse   195 AISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVG--ICYQIAFTVGLLILAGVAY 257
            :......|....||:.||.:...:.:.|||:.|::. ...||.|  |...:.:..||:.....|.
  Fly   167 SFVHTLPWFAFSRFMSGLSTDTMYYLMYILVFEYLS-PKSRTFGLNIILAVFYCFGLMTSPWAAI 230

Mouse   258 ALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNGKSVPVSL---- 318
            .:.|||...:..:||....|:|.:.|.||.:||:::.|...|:..:|.:||.|.:.|..|:
  Fly   231 WIGNWRRYLWLASLPALGVLIYPFLICESAQWLLTKRKYDDAVICLKKVAKFNRRHVEESVFDEF 295

Mouse   319 -----------QSLTADEDTGMKLNPSFLDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLA 372
                       ..|.:.|||       ||.:..||::|:.||.|:......::....:..:|...
  Fly   296 VKYYRERELQDYKLNSHEDT-------FLAMFLTPRLRRFTLTLLVKSVIITLSCDVINRNMEGL 353

Mouse   373 GDNIYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFI-----PDDLQWLK 432
            |.:.:..|.::::|..||...|:|..::|||:.....:..|.|....|:.|:     |.:...|.
  Fly   354 GTSPFKLFSFTSIVYLPAGVAILLLQNKIGRKGMACTALFVGGLITTATGFMIAHLDPTENALLL 418

Mouse   433 ITVACLGRMGITIAYEMVCLVNAELYPTYIRNLAV-------LVCSSMCDIGGIVTPFLVYRLTD 490
            ..:..|||.|.|::|:......||:.||.:|..||       |..||:.        |.|..|..
  Fly   419 AIMVGLGRFGATVSYDAEIQYAAEIIPTSVRGQAVSNIHVIGLASSSLA--------FYVIYLAQ 475

Mouse   491 IWLEFPLVVFAVVGLVAGGLVLLLPETKGKALPETIEDAEKMQRPR--------KKKEKRI 543
            .:...|.:..:.:.....||.|.||||..|.||||:.|.||.....        .:|||.:
  Fly   476 YYKPLPSIFISCLMFFGAGLCLTLPETLNKKLPETLADGEKFALNESFLYFPCFSRKEKNV 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	143/548 (26%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	106/397 (27%)
CG7333	NP_650814.2	2A0119	11..510	CDD:273328	143/548 (26%)
CG7333	NP_650814.2	MFS	126..499	CDD:119392	101/388 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950