DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a2 and SLC22A

DIOPT Version :9

Sequence 1:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus
Sequence 2:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	167/558 - (29%)
Similarity:	269/558 - (48%)	Gaps:	34/558 - (6%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 TVDDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPNHHCRSPGVAELSQRCGWSPA 67
            |:|.||:|:|:|..||...|.|:.|.........|..||...|..|.| |....:|.....:.|
  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC-SVEECDLPGSNYYEP- 88

Mouse    68 EELNYTVPGLGSAGEVSFLSQCMRYE----VDWNQSTLDCVDPLSSLAANRSHLPLSPCEHG-WV 127
             ..|:::|..|..     |..|.||.    ..||.|...|       :|:........|.|. :|
  Fly    89 -HTNWSIPKNGKD-----LDSCNRYTNSELPQWNHSVDIC-------SADHFTKNKEACAHNEFV 140

Mouse   128 YDTPGSSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKFCLLVTILINAISGV 192
            :.....:|..:|.:.|...|.|.:..::.|:|.|.|....|::|||:||.|.:.:..::.|:.||
  Fly   141 FRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV 205

Mouse   193 LMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQIA--FTVGLLILAGV 255
            :.:.||:|.|.|||.||..:.|...:...:::..|.|  |.:|.|..|..|.  :.||.::||..
  Fly   206 IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELV--GPKRRVLACSVITVFYAVGEVLLAMS 268

Mouse   256 AYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNGKSVPVSL-- 318
            |.|..:||.|......|:...|.|||.:|||.|||:||.|..:|..|::..|..|.:.:|.|:
  Fly   269 AKAFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLD 333

Mouse   319 QSLTADEDTGMKLNPSFLDLVRTPQIRKHTLILMYN----WFTSSVLYQGLIMHMGLAGDNIYLD 379
            :.:.|:.|   ||..|........:..|:....:.|    |....::|.||.:::.|...:.|.:
  Fly   334 KLVLANRD---KLQQSSESRFPIREAFKNFKWRIANCSLCWIVHVLVYYGLSLNVVLLDGDKYNN 395

Mouse   380 FFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITVACLGRMGIT 444
            |.|.||||.|..|:.:|.:||.||||......:.:|..|:.::|...|...|::.:..:|::.||
  Fly   396 FAYIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTIT 460

Mouse   445 IAYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFAVVGLVAGG 509
            .:::::....:|:|||.:||..:..||.|...|.::.| ....|...:...|.::||...:|:|.
  Fly   461 ASFQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP-QTPLLAKYYANAPAMLFAGAAIVSGL 524

Mouse   510 LVLLLPETKGKALPETIEDAEKMQRPRKKKEKRIYLQV 547
            |.|..|||....||.|:::|:.:...::.|.|.:.|.|
  Fly   525 LTLFFPETTNVVLPTTVQEADAIGVKKQSKSKDLDLVV 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	156/525 (30%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	114/375 (30%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	156/525 (30%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	120/389 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030