DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a2 and CG4630

DIOPT Version :9

Sequence 1:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	171/583 - (29%)
Similarity:	269/583 - (46%)	Gaps:	79/583 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 DDILEHIGEFHLFQKQTFFLLALLSGAFTPIY------VGIVFLGFTPNHHCRSP---GVAELSQ 60
            ||||..||||..||::.:.|:.|      |:.      :..||...:|.:.|..|   .:.:...
  Fly    16 DDILVEIGEFGRFQRRNYLLICL------PVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEY 74

Mouse    61 RCGWSPAEELNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCE-- 123
            ...|     ::..|||..|.......|.|.|:..:.        |.|.|.:...|..||..|.
  Fly    75 GANW-----VSIAVPGSWSKRGHFTPSTCERFVANG--------DHLESSSDPWSAWPLDQCFAE 126

Mouse   124 ---------HGWVYDTPGSSIVTEFNLVCAHS-WMLDLFQSLVNVGFFIGAVGIGYLADRFGRKF 178
                     :.:||.:...:||.::.|.|..: |.|....::...|..:|....||||||:|||.
  Fly   127 NFTTETERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKH 191

Mouse   179 CLLVTILINAISGVLMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQI 243
            ..|..|:..|::||..|:|.:|...|.|..|..:.:...:.:.:|:..|.||...|....|....
  Fly   192 IFLFCIVFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNY 256

Mouse   244 AFTVGLLILAGVAYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAK 308
            .:.||..:| |::..||:||.||.|:::|....:.|||.:|||.|||:::|:..:|..||:..||
  Fly   257 FYAVGEALL-GLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAK 320

Mouse   309 KNGKSVPVSL------QSLTA------DEDTGMKLNPSFLDLVRTPQI-RKHTL-----ILMYNW 355
            .|.:.:.|.|      |.|.|      |.:.|:.:.......:...:: |.|.|     ||:..|
  Fly   321 VNRRDISVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIW 385

Mouse   356 FTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLA 420
            ..::::|.||.::......|.||:|....|||.|...:..|.:.|.|||...:.|.::....|:|
  Fly   386 AVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVA 450

Mouse   421 SVFIP-------------------DDLQWLKITVACLGRMGITIAYEMVCLVNAELYPTYIRNLA 466
            |.|:.                   ....||.:|:..:|::|||.::.::....||:.||.||:..
  Fly   451 SGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGG 515

Mouse   467 VLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFAVVGLVAGGLVLLLPETKGKALPETIEDA 529
            |.|.|:....|.::.|| |..|...:...||::|..:.||||.|.||||||..:.||:|:|:|
  Fly   516 VGVMSTFARFGAMLAPF-VPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEA 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	163/570 (29%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	119/404 (29%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	163/570 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	111/376 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930