DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc22a1 and SLC22A

DIOPT Version :9

Sequence 1:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus
Sequence 2:	NP_649370.1	Gene:	SLC22A / 40437	FlyBaseID:	FBgn0037140	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	167/551 - (30%)
Similarity:	266/551 - (48%)	Gaps:	31/551 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse     3 TVDDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSPGVAELSQRCGWSPA 67
            |:|.:|:|:|:||.||...|||:||.....|...|..||...|..|.| |....:|.....:.|
  Fly    26 TLDAILKHLGQFGRFQLIIFLLICLPMMFHAMFSVTYVFTAATVTHRC-SVEECDLPGSNYYEP- 88

Mouse    68 EELNYTVPGLGSAGEASFLSQCMKYE----VDWNQSTLDCVDPLSSLAANRSHLPLSPCEHG-WV 127
             ..|:::|..|..     |..|.:|.    ..||.|...|       :|:........|.|. :|
  Fly    89 -HTNWSIPKNGKD-----LDSCNRYTNSELPQWNHSVDIC-------SADHFTKNKEACAHNEFV 140

Mouse   128 YDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLSGV 192
            :.....:|..:|.:.|.|.||:.:..:..|||.|.|..:.|::|||:||...:.:..::.::.||
  Fly   141 FRDDEVTISNDFGIFCDDEWKLSMVGTINNLGQFFGIPIGGFVADRYGRSFSIALGGILGAVLGV 205

Mouse   193 LTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGVAY 257
            :.:.:|.|...|:|..|..|.|...:.:.:.:..|.||...|.....:..|.:.||.|.||..|.
  Fly   206 IRSFSPSYGWFLVFEFLDNMTSSTLYSTCFVIGIELVGPKRRVLACSVITVFYAVGEVLLAMSAK 270

Mouse   258 AIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKN-RKVPPADLKMM 321
            |..|||.|......|:.:.|.|:|.:|||.||||||.:..:|..|:.:.|..| |::|.:.|..:
  Fly   271 AFHDWRILLRITYGPSLILLAYFWILPESVRWLLSQGKEERAKNILRRAAHVNKRELPESVLDKL 335

Mouse   322 CLE-----EDASERRSPSFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANLYLDFF 381
            .|.     :.:||.|.| ..:.|:....|.....|  .|....::|.||.::|.....:.|.:|.
  Fly   336 VLANRDKLQQSSESRFP-IREAFKNFKWRIANCSL--CWIVHVLVYYGLSLNVVLLDGDKYNNFA 397

Mouse   382 YSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGRMGATIV 446
            |.:|||.|..|:.|:.:||.||.|.:....|.:|..|:..||...:...|.:.|..:|::..|..
  Fly   398 YIALVEIPGFFMPLLIMDRFGRRYSLCGLMLASGLCCIGTIFTGADQPVLQLVLFLVGKLTITAS 462

Mouse   447 LQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLSAGAVT 511
            .|::....:|:|||.:||..:..||.:...|.:..| ....|.:.:...|.:||....:.:|.:|
  Fly   463 FQVLYFFASEIYPTNLRNSLLSFCSMMGRFGSMLAP-QTPLLAKYYANAPAMLFAGAAIVSGLLT 526

Mouse   512 LLLPETKGVALPETIEEAENLG-RRKSKAKE 541
            |..|||..|.||.|::||:.:| :::||:|:
  Fly   527 LFFPETTNVVLPTTVQEADAIGVKKQSKSKD 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	156/523 (30%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	117/396 (30%)
SLC22A	NP_649370.1	2A0119	35..540	CDD:273328	156/523 (30%)
SLC22A	NP_649370.1	MFS	146..530	CDD:119392	116/387 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960