DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a1 and CG4630

DIOPT Version :9

Sequence 1:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	582	Identity:	173/582 - (29%)
Similarity:	274/582 - (47%)	Gaps:	67/582 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 DDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSP---GVAELSQRCGWSP 66
            ||:|..:||||.||::.:||:||.....|...:..||...:|.:.|..|   .:.:......|
  Fly    16 DDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGANW-- 78

Mouse    67 AEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCE-------- 123
               ::..|||..|.......|.|.::..:.        |.|.|.:...|..||..|.
  Fly    79 ---VSIAVPGSWSKRGHFTPSTCERFVANG--------DHLESSSDPWSAWPLDQCFAENFTTET 132

Mouse   124 ---HGWVYDTPGSSIVTEFNLVCGD-AWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTT 184
               :.:||.:...:||.::.|.|.: .||:....:....|..:|:.:.||:|||:|||...|...
  Fly   133 ERCNQFVYGSSERTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCI 197

Mouse   185 LVTSLSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGL 249
            :..:|:||..|::.||.|.|.|.||..:.:.|.:...:.:..|.||...|..::|:....:.||
  Fly   198 VFMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVG- 261

Mouse   250 VGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVP 314
            ..|.|::..:||||.||||:|:|..:.:.|:|.||||.||||::.|..||..|:.:.|:.||:..
  Fly   262 EALLGLSVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDI 326

Mouse   315 PADL----KMMCLEEDASERRSP--------------SFADLFRTPSLRKHTLILMYLWFSCAVL 361
            ..:|    |...|:.:..:....              :..::.|:..|.....||:.:|...|::
  Fly   327 SVELMASFKQQELDAETGQEDDVEGGLHVKKDDKIWLAVKEVARSHILMGRYAILLLIWAVNAIV 391

Mouse   362 YQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIP- 425
            |.||.::..:...|.||:|....|||.|...:..:.:.|.||...::.|.|:....|:...|:.
  Fly   392 YYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVASGFVTL 456

Mouse   426 ---------------HE---LHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSA 472
                           |.   .:||.|||..:|::|.|....::....||:.||.||:.|:.|.|.
  Fly   457 AQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGGVGVMST 521

Mouse   473 LCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLSAGAVTLLLPETKGVALPETIEEAENLGR 534
            ....|.:..||:.. |...:..|||:|||.|.|.||.::||||||....||:|:|||..||:
  Fly   522 FARFGAMLAPFVPL-LASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIALGK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	164/564 (29%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	128/427 (30%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	164/564 (29%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	108/375 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860