DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc1a3 and Eaat2

DIOPT Version :9

Sequence 1:	NP_683740.1	Gene:	Slc1a3 / 20512	MGIID:	99917	Length:	543	Species:	Mus musculus
Sequence 2:	NP_001162844.1	Gene:	Eaat2 / 33247	FlyBaseID:	FBgn0026438	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	204/478 - (42%)
Similarity:	312/478 - (65%)	Gaps:	15/478 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse    42 KSYLFRNAFVLLTVTAVIVGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVT 106
            :.:|..|..:|:|::.|::|.|||.:|||..:....:...|:||||.||:|::::|||:||||:.
  Fly    43 RRWLSENLMLLVTLSGVLLGVILGLSLRPLNLHGDSIMLISYPGELFMRVLKLMILPLVISSLIA 107

Mouse   107 GMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENM-YREGKIVQVTAADAF 170
            |.|:|::|.:||:.:|.:||:.:|:.....:||.:|::||||.....|. .|......|...|:.
  Fly   108 GSASLNAKMNGKIALRTLVYFASTSFFNAALGIALVLLIHPGNPDLHNADDRSTDRRAVNLLDSL 172

Mouse   171 LDLIRNMFPPNLVEACFKQFKTSYEKRSFKVPIQS-----NETLLGAVINNVSEAMETLTRIREE 230
            |||.||:||.||.:|..:|..|.|      :|..|     |||:...:.:. |||......:.|:
  Fly   173 LDLGRNVFPDNLFQASIQQAHTVY------LPKPSILHVFNETMNDTLASG-SEAQRLSEDLTED 230

Mouse   231 MVPVPGSV--NGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGI 293
            :|.|....  :|.|.||:|.|.:.||..:|.:.::||.:.:||.::.|.||::|..:||..|:||
  Fly   231 VVLVRDIQYRSGTNTLGIVFFCLVFGTFLGTIGQKGQVVVDFFAAIFEVIMKMVTCVMWLTPVGI 295

Mouse   294 LFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALIT 358
            ..:|||||:.:.|:|::..||..:.|||.:|:.|:..:|:..:||:|.|:||:.|..||:||::|
  Fly   296 SSVIAGKILSVGDLGLVMSQLMWFIVTVAIGVFIYQFVVMQAIYFVVVRRNPFKFYAGLIQAMLT 360

Mouse   359 ALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFIAQVNNFDLNF 423
            |..|:|::|.|||||:|:.|...||.||||||||:|..|||||||||.|:|:|||||::...|.|
  Fly   361 AFATASTAAALPITFRCMNEKLKVDPRITRFVLPIGCNINMDGTALYIAVASIFIAQMSGMVLGF 425

Mouse   424 GQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDS 488
            |:::|:.:|:||||:.:|.:|.|.||.:::|||::..|..|:||:.|||||:||:|||.|:|||.
  Fly   426 GELLTVLLTSTAASMSSASVPSAALVLLLVVLTAIDAPVQDVTLLFAVDWFVDRIRTTNNMLGDC 490

Mouse   489 LGAGIVEHLSRHELKNRDVEMGN 511
            ..|.:||.|||.||...|....|
  Fly   491 YTAAVVEELSRKELMALDAASVN 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc1a3	NP_683740.1	SDF	50..497	CDD:278787	195/454 (43%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:O59010	363..365		0/1 (0%)
		Aspartate binding. /evidence=ECO:0000250\|UniProtKB:P43003	443..447		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..543
Eaat2	NP_001162844.1	SDF	51..496	CDD:278787	193/451 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62336
OrthoDB	1	1.010	-	-		D1184392at2759
OrthoFinder	1	1.000	-	-		FOG0000144
OrthoInspector	1	1.000	-	-		otm42841
orthoMCL	1	0.900	-	-		OOG6_100309
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X191
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.730