DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHB4 and vab-1

DIOPT Version :9

Sequence 1:	XP_016867305.1	Gene:	EPHB4 / 2050	HGNCID:	3395	Length:	1005	Species:	Homo sapiens
Sequence 2:	NP_494807.1	Gene:	vab-1 / 173794	WormBaseID:	WBGene00006868	Length:	1117	Species:	Caenorhabditis elegans

Alignment Length:	1166	Identity:	369/1166 - (31%)
Similarity:	550/1166 - (47%)	Gaps:	259/1166 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     5 VLLCWASLAAALEETLLNTKLETADLKWVTFPQV-----------DGQWEELSGLDEEQHSVRTY 58
            ||.|..::..:.:|.|.:.....:||||   .||           :..|...:..||:..:.|.|
Worm    19 VLQCLITIVTSHQEVLFDLSKVGSDLKW---DQVSLRHDRDDVWMEETWRNPAATDEKHANQRAY 80

Human    59 EVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFY-------- 115
            ..|:.... ..::||.:.::..:.|..:|..|.|...:|.:.... :||||||:|:.
Worm    81 VTCNYDMI-NPSNWLFSHFIEVKTARRIYIELLFNTRDCDAYLNP-KSCKETFSVYLKQFKTSRP 143

Human   116 ---------YESDADTATALTPAWMENPYIKVDTVAA--EHLTRKRPGAEATGKVNVKTLRLGPL 169
                     :..|.|.       |.     .:..:|.  .::|.:..|.|...  :.||:|
Worm   144 GSTKIEKERFSEDIDN-------WK-----NIGRLARSNSNMTTETLGMEIDS--DTKTIR---- 190

Human   170 SKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRF-PE-TVPREL-VVPVAGSCVVDA-VPA 230
                  :||::||.|::||::.::|:.|.:.|..|..| |: |.|:|. :|.:.|||:.:| ...
Worm   191 ------IAFEEQGICLSLLNVKIYYRICDEFTDQLVYFRPQVTGPKETDMVRMNGSCIPNASKKI 249

Human   231 PGPSPSLYCREDGQWAEQPVTG-CSCAPGF-EAAEGN-TKCRACAQGTFKPLSGEGSCQPCPANS 292
            ||......|...|...:  .:| |.|..|: :.|:.| .:|.:|...|:|| .|:..|:.||:||
Worm   250 PGVDLIGLCMSTGSGIK--TSGECVCDSGYSQIADSNGARCESCPTNTYKP-KGQSLCKSCPSNS 311

Human   293 HSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAP-RSVVSRLNGSSLHLEWSAPLESGGREDLT 356
            .|:...|: |:|..|||||..:....|||.|||.| :.|.:.:..:|..|.|:.|...|||.::.
Worm   312 ISSEAASS-CRCLNGYFRAEDELISMPCTQPPSRPIKLVANAITATSTRLSWNEPSSLGGRPEIW 375

Human   357 YALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVP 421
            |.::   |...|.|    |.:...||.:.|....|.:.||||...|||.|.|.|.||  |..| .
Worm   376 YEVK---CSGRGEC----GTVVMTPGDKKLSTRSVQINGLRPSSDYTFLVFAKNKVS--AQFP-E 430

Human   422 FEPVNVTTDREVKGQSYHAQGFPVSLPLTVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYE 486
            |...|...|...:.:..           .||| ||.:||..|....:::||:|   ....|.|:|
Worm   431 FSEKNAVIDIRTRSEEE-----------DVPP-VSHLRVDASQSDGITIAWSV---SDSDVSDFE 480

Human   487 VKYHEKGAEGPSSVRFLKTSENR------AELRGLKRGASYLVQVRARSEAGYG-PFGQE----- 539
            |:..      |:.|: .:|.|.|      ....||.....|..:||.|.:..:. |...:
Worm   481 VEVR------PAIVK-KRTFETRHVNMTYTTFIGLNPETVYQFRVRIRDDLRWSQPISYQLGRGL 538

Human   540 --HHSQTQLDESEGWREQLALIAGTAVVGVVLVLVVIVVAV-LCL---RKQSNGREAEYSD---- 594
              ..|..:::||:...:     .|:|:: :::.|::||:|| ||:   :|:|..|: :.||
Worm   539 MSSPSSNEVEESQFLNQ-----TGSALL-IIIALILIVIAVALCMIVVQKKSKNRK-QMSDLDVL 596

Human   595 ----------------KH----------------------------------------------- 596
                            :|
Worm   597 DTYKQDSMTPDYHTTSRHHHHQGNLPATLHEQLRSTTKLNAPLIPSFGSPISQPPPYYGGVHPNS 661

Human   597 GQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRL--KAP---- 655
            |:|      |.|:||.|||||.:|:.||..:|..:.|.|.:|||.||||:||.|.|  .:|
Worm   662 GKY------KTYVDPTTYEDPYQALIEFTFDISPNDVFITQVIGGGEFGDVCLGGLSKNSPAAAK 720

Human   656 --------------GKKES----CVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVT 702
                          |..||    .|||||||.|.:.:.:.|||:||:|||||.|||:|||.||||
Worm   721 WSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAKAKAEFLTEATIMGQFSHPNVIRLIGVVT 785

Human   703 NSMPVMILTEFMENGALDSFLRLNDGQFTVI---QLVGMLRGIASGMRYLAEMSYVHRDLAARNI 764
            ::.||||:.|:|.||:||.|||..|.:...:   ::..||.||||||:||.:|.||||||||||:
Worm   786 SAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGYVHRDLAARNV 850

Human   765 LVNSNLVCKVSDFGLSRFL--EENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIV 827
            |::..|.||::||||||.:  |.:|.:|.||:: |||||:||||||||..||||.:||.||:|:|
Worm   851 LLDMELRCKIADFGLSRGVRSEGSSVEPEYTTN-GGKIPVRWTAPEAITHRKFTPSSDVWSFGVV 914

Human   828 MWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL 892
            :|||.|||||||||.:||.||:.:...||||||.|||..|:::...||:.:|:.||.|.|:::..
Worm   915 IWEVCSFGERPYWDWTNQKVISEVMIGYRLPPPMDCPMGLYRIAQWCWKMERHERPTFTQLLATF 979

Human   893 DKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVG------------------EWLRAIKM 939
            .|.|..|..:     |:.....|...|.|...:.:|||.                  ::||.|.:
Worm   980 HKYILQPTLI-----EHDPGELPRRVQSQSALNTYGSVNVGVVPTPPSSAAPMPSLDDFLRQIGL 1039

Human   940 GRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGG 1000
            ........:....|...::..|..|||..|:..|.     .::|:...:....|:|.|:.|
Worm  1040 NHVYGQLVSNNIHSVSDLANTSHLDLLAYGLMSAE-----CSTVRDGLNGRISGSPPGSSG 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHB4	XP_016867305.1	EphR_LBD_B4	17..196	CDD:198442	46/208 (22%)
		FN3	324..429	CDD:238020	36/105 (34%)
		FN3	452..544	CDD:238020	27/105 (26%)
		EphA2_TM	<582..628	CDD:291255	20/112 (18%)
		PTKc_EphR_B	628..896	CDD:173638	153/296 (52%)
		Pkinase_Tyr	633..892	CDD:285015	151/287 (53%)
		SAM	922..989	CDD:197735	14/84 (17%)
		SAM_EPH-B4	925..991	CDD:188953	14/83 (17%)
vab-1	NP_494807.1	EphR_LBD	32..211	CDD:198439	46/207 (22%)
		FN3	342..423	CDD:238020	29/87 (33%)
		FN3	450..531	CDD:238020	26/91 (29%)
		EphA2_TM	<642..687	CDD:291255	14/50 (28%)
		PTKc_EphR	687..983	CDD:270629	153/296 (52%)
		STYKc	692..979	CDD:214568	151/287 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	295	1.000	Domainoid score	I891
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I753
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		otm16171
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880