DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EPHB3 and YPL150W

DIOPT Version :9

Sequence 1:	NP_004434.2	Gene:	EPHB3 / 2049	HGNCID:	3394	Length:	998	Species:	Homo sapiens
Sequence 2:	NP_015175.1	Gene:	YPL150W / 855953	SGDID:	S000006071	Length:	901	Species:	Saccharomyces cerevisiae

Alignment Length:	433	Identity:	101/433 - (23%)
Similarity:	175/433 - (40%)	Gaps:	95/433 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   618 NEAVREFAKE--IDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFL 680
            |....:|..:  .:|...||.:.||.|.||:|... |.:|..|:  |.:||     :::...:.:
Yeast    24 NRLYSQFTSDELTEVGNYKILKQIGEGSFGKVYLA-LHRPTHRK--VCLKT-----SDKNDPNIV 80

Human   681 SEASIMGQFDHPNIIRL-EGVVTKSRPVMILTEFMENC----ALDSFLRLNDGQFTVIQLVGMLR 740
            .|.....|||.|.|.:| |.:||:|:..|.|    |.|    ..|..|.|.  :.::::...:..
Yeast    81 REVFYHRQFDFPYITKLYEVIVTESKVWMAL----EYCPGKELYDHLLSLR--RISLLECGELFA 139

Human   741 GIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWT 805
            .|:..:.|...|:.|||||...|||::.|...|::|||.:|   :..:..|..:..|..:   :.
Yeast   140 QISGAVYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTR---ECMTKTTLETVCGTTV---YM 198

Human   806 APEAIAYRKFTSAS-DVWSYGIVMWEVMSYGERPY---------WDMSNQDVINAVEQDYRLPPP 860
            |||.|..|.:.... |:||.|::::.::: |..|:         |.:.|::            |.
Yeast   199 APELIERRTYDGFKIDIWSLGVILYTLIT-GYLPFDDDDEAKTKWKIVNEE------------PK 250

Human   861 MDC---PTALHQLMLDCWVRDRNLRPKFSQIVN----------TLDK----LIRNAAS------- 901
            .|.   |.....|:.....::...||..||::.          .||:    |.|..:.
Yeast   251 YDAKVIPDDARDLISRLLAKNPGERPSLSQVLRHPFLQPYGSVVLDQTQKILCRQRSGGTQFKSK 315

Human   902 -----LKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFV----SAGFASFDLV 957
                 ||.:  .|||:....:.:::......:..|.||..:..|:.:|:..    |....|...|
Yeast   316 LERRLLKRL--KQSGVDTQAIKQSILKKKCDSLSGLWLLLLAQGKKQENCKYPKRSRSVLSVKKV 378

Human   958 AQMT--------AEDLLRIGVTL--AGHQKKILSSIQDMRLQM 990
            .:..        :||:|:..:.|  |....|:|:...|....|
Yeast   379 IESATHNDTNGISEDVLKPSLELSRAASLSKMLNKGSDFVTSM 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHB3	NP_004434.2	EphR_LBD_B3	39..211	CDD:198446
		Ephrin_rec_like	<284..316	CDD:311571
		fn3	341..436	CDD:365830
		FN3	<473..542	CDD:238020
		EphA2_TM	<581..628	CDD:373140	2/11 (18%)
		PTKc_EphR_B	628..896	CDD:173638	75/299 (25%)
		SAM_superfamily	922..990	CDD:387673	16/81 (20%)
YPL150W	NP_015175.1	STKc_AMPK-like	40..286	CDD:270905	72/278 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910