DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHB3 and BCK1

DIOPT Version :9

Sequence 1:	NP_004434.2	Gene:	EPHB3 / 2049	HGNCID:	3394	Length:	998	Species:	Homo sapiens
Sequence 2:	NP_012440.1	Gene:	BCK1 / 853350	SGDID:	S000003631	Length:	1478	Species:	Saccharomyces cerevisiae

Alignment Length:	1033	Identity:	212/1033 - (20%)
Similarity:	356/1033 - (34%)	Gaps:	339/1033 - (32%)

- Green bases have known domain annotations that are detailed below.

Human     5 RPPPPPSPPPGLLPLLPPLLLLPLLLLPAGCRALEETLMDTKWVTSELAWTSHPE--SGWEEVSG 67
            :|.|.|......:||..   :.....:.:|..:|..:..|...|||....||..|  ||    ||
Yeast   644 KPKPAPLTSENNVPLKS---VKSKSSMRSGTSSLIASTDDVSIVTSSSDITSFDEHASG----SG 701

Human    68 ----------YDEA--MNPIRTYQVCNVRE--SSQNNWLRTGFIWRRDVQRVYVELKFTVRDCNS 118
                      ||..  .||.......|::|  |.:.|..:..|       :...:|:..:.|..|
Yeast   702 RRYPQTPSYYYDRVSNTNPTEELNYWNIKEVLSHEENAPKMVF-------KTSPKLELNLPDKGS 759

Human   119 IPNIP-----GSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAGRVNTKV 178
            ..|||     ...|.:|.:...:..:::   ......|:||.|.: :||.....:..|   ||..
Yeast   760 KLNIPTPITENESKSSFQVLRKDEGTEI---DFNHRRESPYTKPE-LAPKREAPKPPA---NTSP 817

Human   179 RSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETLTGAEPTSLVIAPGTCIP 243
            :.....||         |...:.|:.        |||....:...:.|    |..|:.:|
Yeast   818 QRTLSTSK---------QNKPIRLVR--------ASTKISRSKRSKPL----PPQLLSSP----- 856

Human   244 NAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRPCP-----PGSYKAKQGEGPCLP 303
              :|                        |:...|.:..|...|..     |..||........|.
Yeast   857 --IE------------------------ASSSSPDSLTSSYTPASTHVLIPQPYKGANDVMRRLK 895

Human   304 CPPNSRTTSPA-----------ASICTCHNNFYRADSDSADSACTTVPSP--PRG----VISNVN 351
            ...:|.:|||:           :::.|.::.||.             |||  .||    |:|:.:
Yeast   896 TDQDSTSTSPSLKMKQKVNRSNSTVSTSNSIFYS-------------PSPLLKRGNSKRVVSSTS 947

Human   352 ------ETSLILEWSEPR--------DLGGRDDLLY---------NVICKKCHGAGGASACSRCD 393
                  |..:....:.|.        |....||:::         |...||...:..:|..|
Yeast   948 AADIFEENDITFADAPPMFDSDDSDDDSSSSDDIIWSKKKTAPETNNENKKDEKSDNSSTHS--- 1009

Human   394 DNVEFVPRQLGLTERR---------VHISHLLAHTRYTFEVQAVNGVSGKSPLPPR-----YAAV 444
            |.:.:..:.....||:         |:.:......|...:.....|::  ||..|:     .:..
Yeast  1010 DEIFYDSQTQDKMERKMTFRPSPEVVYQNLEKFFPRANLDKPITEGIA--SPTSPKSLDSLLSPK 1072

Human   445 NITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSEGIASTVTSQMNSVQ 509
            |:.:::..||                    .|.||......||.                   :|
Yeast  1073 NVASSRTEPS--------------------TPSRPVPPDSSYEF-------------------IQ 1098

Human   510 LDGLRPDARYVVQVRA-------RTVAGYGQYSRPAEFETTSERGSGAQQLQEQLPLIVGSATAG 567
             |||....:.:.|.:.       ||:|.....:|           ..:.:|:.|...:.|:.
Yeast  1099 -DGLNGKNKPLNQAKTPKRTKTIRTIAHEASLAR-----------KNSVKLKRQNTKMWGTR--- 1148

Human   568 LVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREFAKEIDVSC 632
               :|.|....:|.:.|.:: |..||                            :|||      .
Yeast  1149 ---MVEVTENHMVSINKAKN-SKGEY----------------------------KEFA------W 1175

Human   633 VKIEEVIGAGEFG------EVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFL-------SEAS 684
            :| .|:||.|.||      .|..|.:         :|:|.::|.....|....|       ||.|
Yeast  1176 MK-GEMIGKGSFGAVYLCLNVTTGEM---------MAVKQVEVPKYSSQNEAILSTVEALRSEVS 1230

Human   685 IMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYL 749
            .:...||.||::..|...|:....:..|::...::.|.:|:. |:|....:..:...:..|:.||
Yeast  1231 TLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMY-GRFDEPLIKHLTTQVLKGLAYL 1294

Human   750 SEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLED--DPSDPTYTSSLGGKIPIRWTAPEAIAY 812
            .....:|||:.|.|:|::.:.:||:||||:||..:|  ..||.|...:      :.|.|||.:..
Yeast  1295 HSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGT------VFWMAPEMVDT 1353

Human   813 RKFTSAS-DVWSYGIVMWEVMSYGERPYWDMSNQDVINA---VEQDYRLPP-PMDCPTALHQL-- 870
            ::..||. |:||.|.::.|:.: |:||:   ||.:|:.|   :.:....|| |.|....:.|:
Yeast  1354 KQGYSAKVDIWSLGCIVLEMFA-GKRPW---SNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGR 1414

Human   871 -MLD-CWVRDRNLRP--------KFSQIVNTL--------------DKLIRNAASLKV 904
             .|| |:..:...||        .||::..|.              |||  |::.|::
Yeast  1415 NFLDACFEINPEKRPTANELLSHPFSEVNETFNFKSTRLAKFIKSNDKL--NSSKLRI 1470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHB3	NP_004434.2	EphR_LBD_B3	39..211	CDD:198446	41/192 (21%)
		Ephrin_rec_like	<284..316	CDD:311571	9/47 (19%)
		fn3	341..436	CDD:365830	22/132 (17%)
		FN3	<473..542	CDD:238020	14/75 (19%)
		EphA2_TM	<581..628	CDD:373140	7/46 (15%)
		PTKc_EphR_B	628..896	CDD:173638	82/313 (26%)
		SAM_superfamily	922..990	CDD:387673
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	79/293 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910