Protein Alignment EPHB3 and vab-1

DIOPT Version :10

• Sequence 1: NP_004434.2
• Gene: EPHB3 / 2049
• HGNCID: 3394
• Length: 998
• Species: Homo sapiens
• Sequence 2: NP_494807.1
• Gene: vab-1 / 173794
• WormBaseID: WBGene00006868
• Length: 1117
• Species: Caenorhabditis elegans
• Alignment Length: 1085
• Identity: 358/1085 - (32%)
• Similarity: 528/1085 - (48%)
• Gaps: 192/1085 - (17%)

Human    39 EETLMDTKWVTSELAWTS----HP------ESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLR 93
            :|.|.|...|.|:|.|..    |.      |..|...:..||.....|.|..||....:.:|||.
 Worm    31 QEVLFDLSKVGSDLKWDQVSLRHDRDDVWMEETWRNPAATDEKHANQRAYVTCNYDMINPSNWLF 95

Human    94 TGFIWRRDVQRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVD 158
            :.||..:..:|:|:||.|..|||::..| |.||||||:::..:..:....::.        ::.:
 Worm    96 SHFIEVKTARRIYIELLFNTRDCDAYLN-PKSCKETFSVYLKQFKTSRPGSTK--------IEKE 151

Human   159 TIAPD----ESFSRLDAGRVNTKVRSFG---PLSKAGFYLAFQDQGACMSLISVRAFYKKCASTT 216
            ..:.|    ::..||.....|....:.|   ........:||::||.|:||::|:.:|:.|...|
 Worm   152 RFSEDIDNWKNIGRLARSNSNMTTETLGMEIDSDTKTIRIAFEEQGICLSLLNVKIYYRICDEFT 216

Human   217 AGFALFPETLTGAEPTSLVIAPGTCIPNAVE--VSVPLKLYCNGDGEWMVPVGACTCATGHEPAA 279
            .....|...:||.:.|.:|...|:|||||.:  ..|.|...|...|..:...|.|.|.:|:...|
 Worm   217 DQLVYFRPQVTGPKETDMVRMNGSCIPNASKKIPGVDLIGLCMSTGSGIKTSGECVCDSGYSQIA 281

Human   280 KE--SQCRPCPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSP 342
            ..  ::|..||..:||.| |:..|..||.|| .:|.|||.|.|.|.::||:.:.....||..||.
 Worm   282 DSNGARCESCPTNTYKPK-GQSLCKSCPSNS-ISSEAASSCRCLNGYFRAEDELISMPCTQPPSR 344

Human   343 PRGVISN-VNETSLILEWSEPRDLGGRDDLLYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLT 406
            |..:::| :..||..|.|:||..||||.::.|.|   ||.|.|      .| ..|...|....|:
 Worm   345 PIKLVANAITATSTRLSWNEPSSLGGRPEIWYEV---KCSGRG------EC-GTVVMTPGDKKLS 399

Human   407 ERRVHISHLLAHTRYTFEVQAVNGVSGKSP-LPPRYAAVNITTNQAAPSEVPT---LRLHSSSGS 467
            .|.|.|:.|...:.|||.|.|.|.||.:.| ...:.|.::|.| ::...:||.   ||:.:|...
 Worm   400 TRSVQINGLRPSSDYTFLVFAKNKVSAQFPEFSEKNAVIDIRT-RSEEEDVPPVSHLRVDASQSD 463

Human   468 SLTLSWAPPERPNGVILDYEMKYFEKSEGIASTVTSQMNSVQLD-----GLRPDARYVVQVRART 527
            .:|::|:..:..   :.|:|:   |....|....|.:...|.:.     ||.|:..|..:||.|.
 Worm   464 GITIAWSVSDSD---VSDFEV---EVRPAIVKKRTFETRHVNMTYTTFIGLNPETVYQFRVRIRD 522

Human   528 VAGYGQYSRPAEFETTSERGSG------AQQLQE-QLPLIVGSATAGLVFVVAVVVIAIVCL--- 582
            ..   ::|:|..::.    |.|      :.:::| |.....|||...::.::.:|:...:|:
 Worm   523 DL---RWSQPISYQL----GRGLMSSPSSNEVEESQFLNQTGSALLIIIALILIVIAVALCMIVV 580

Human   583 ------RKQRHGSD-----------SEY-----------------------TEKLQQYIAPGM-- 605
                  |||....|           .:|                       |.||...:.|..
 Worm   581 QKKSKNRKQMSDLDVLDTYKQDSMTPDYHTTSRHHHHQGNLPATLHEQLRSTTKLNAPLIPSFGS 645

Human   606 -------------------KVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGR 651
                               |.|:||.|||||.:|:.||..:|..:.|.|.:|||.||||:||.|.
 Worm   646 PISQPPPYYGGVHPNSGKYKTYVDPTTYEDPYQALIEFTFDISPNDVFITQVIGGGEFGDVCLGG 710

Human   652 LKQ--------------PGR--------REVF--VAIKTLKVGYTERQRRDFLSEASIMGQFDHP 692
            |.:              .||        .|.:  |||||||.|.:.:.:.:||:||:|||||.||
 Worm   711 LSKNSPAAAKWSVSNTTMGRGGGGGGYESEPYETVAIKTLKSGSSAKAKAEFLTEATIMGQFSHP 775

Human   693 NIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVI---QLVGMLRGIAAGMKYLSEMNY 754
            |:|||.||||.:.||||:.|:|.|.:||.|||..|.:...:   ::..||.|||:|||||::|.|
 Worm   776 NVIRLIGVVTSAEPVMIVAEYMANGSLDQFLRNTDQRGEKVHWEKITEMLYGIASGMKYLTDMGY 840

Human   755 VHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPS--DPTYTSSLGGKIPIRWTAPEAIAYRKFTS 817
            |||||||||:|::..|.||::||||||.:..:.|  :|.||:: |||||:||||||||.:||||.
 Worm   841 VHRDLAARNVLLDMELRCKIADFGLSRGVRSEGSSVEPEYTTN-GGKIPVRWTAPEAITHRKFTP 904

Human   818 ASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLR 882
            :|||||:|:|:|||.|:|||||||.:||.||:.|...||||||||||..|:::...||..:|:.|
 Worm   905 SSDVWSFGVVIWEVCSFGERPYWDWTNQKVISEVMIGYRLPPPMDCPMGLYRIAQWCWKMERHER 969

Human   883 PKFSQIVNTLDKLI-----------------RNAASLKVIASAQSGM--SQPLLDRTVPDYTTFT 928
            |.|:|::.|..|.|                 ::.::|....|...|:  :.|.....:|
 Worm   970 PTFTQLLATFHKYILQPTLIEHDPGELPRRVQSQSALNTYGSVNVGVVPTPPSSAAPMP------ 1028

Human   929 TVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTLA 973
            ::.|:|..|.:.......||....|...:|..:..|||..|:..|
 Worm  1029 SLDDFLRQIGLNHVYGQLVSNNIHSVSDLANTSHLDLLAYGLMSA 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPHB3	NP_004434.2	EphR_LBD_B3	39..211	CDD:198446	51/188 (27%)
		Ephrin_rec_like	272..316	CDD:429604	16/45 (36%)
		fn3	341..436	CDD:394996	35/95 (37%)
		FN3	<473..542	CDD:238020	16/73 (22%)
		EphA2_TM	560..630	CDD:464211	27/133 (20%)
		PTKc_EphR_B	628..896	CDD:173638	152/296 (51%)
		SAM_superfamily	922..990	CDD:472832	13/52 (25%)
vab-1	NP_494807.1	EphR_LBD	32..211	CDD:198439	51/187 (27%)
		FN3	342..423	CDD:238020	33/90 (37%)
		FN3	450..531	CDD:238020	21/89 (24%)
		PTKc_EphR	687..983	CDD:270629	152/296 (51%)