DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EPHB3 and ephb3

DIOPT Version :9

Sequence 1:	NP_004434.2	Gene:	EPHB3 / 2049	HGNCID:	3394	Length:	998	Species:	Homo sapiens
Sequence 2:	XP_002935194.1	Gene:	ephb3 / 100489199	XenbaseID:	XB-GENE-488644	Length:	974	Species:	Xenopus tropicalis

Alignment Length:	973	Identity:	770/973 - (79%)
Similarity:	867/973 - (89%)	Gaps:	7/973 - (0%)

- Green bases have known domain annotations that are detailed below.

Human    28 LLLLPAGCRALEETLMDTKWVTSELAWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWL 92
            ::|..:..:.||||||||||.||||||.::|:||||||||||||.||||||||||||:.:|||||
Frog     7 VMLALSAVQGLEETLMDTKWTTSELAWVAYPDSGWEEVSGYDEASNPIRTYQVCNVRDGNQNNWL 71

Human    93 RTGFIWRRDVQRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKV 157
            ||.||.|:||||||||||||||||||:||||||||||||.||||:|||.|||.|||||||||:||
Frog    72 RTQFIPRQDVQRVYVELKFTVRDCNSLPNIPGSCKETFNFFYYESDSDSASADSPFWMENPYMKV 136

Human   158 DTIAPDESFSRLDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALF 222
            |||||||||||.|:||||||:|||||||:.||||||||.|||:||||||.|:|||..|.||||.|
Frog   137 DTIAPDESFSRRDSGRVNTKIRSFGPLSRTGFYLAFQDLGACVSLISVRVFFKKCPRTIAGFATF 201

Human   223 PETLTGAEPTSLVIAPGTCIPNAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRPC 287
            |||:||||.||||||||||:|||:||||||||||||||||||||||||||:|.|.|.|::||:.|
Frog   202 PETVTGAEATSLVIAPGTCVPNALEVSVPLKLYCNGDGEWMVPVGACTCASGFEAAGKDTQCQAC 266

Human   288 PPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVNE 352
            ..|:||:|||||.|:|||.|||..|.||:||:|.|.:||||.:||::|||:|||.||.|||||||
Frog   267 KRGTYKSKQGEGSCVPCPVNSRAISSAATICSCQNGYYRADGESAETACTSVPSAPRHVISNVNE 331

Human   353 TSLILEWSEPRDLGGRDDLLYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLA 417
            ||::|||:||..||||||:|||||||||.    ...||||||||:|.|||||:|:|||.:|||.|
Frog   332 TSVVLEWAEPGHLGGRDDILYNVICKKCL----ERLCSRCDDNVQFWPRQLGVTQRRVSVSHLQA 392

Human   418 HTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPNGV 482
            ||:|:||:|||||||||||..|.|..|||||||||||.||.::.|.||.:||||||||||.|||:
Frog   393 HTKYSFEIQAVNGVSGKSPHIPNYYTVNITTNQAAPSAVPMVQSHGSSANSLTLSWAPPESPNGI 457

Human   483 ILDYEMKYFEKSE-GIASTVTSQMNSVQLDGLRPDARYVVQVRARTVAGYGQYSRPAEFETTSER 546
            |||||:||:.|.: |..:|||||..:|:::.:.||..||||||||||||||.||.|.||:|.||.
Frog   458 ILDYEIKYYPKGQSGAGNTVTSQRTTVRMEAMTPDTVYVVQVRARTVAGYGAYSEPREFQTISED 522

Human   547 GSGAQQLQEQLPLIVGSATAGLVFVVAVVVIAIVCL-RKQRHGSDSEYTEKLQQYIAPGMKVYID 610
            |. ...||||:|::|||.||||:|::|||:|.|||. ||||:.::||||||||||:.||||:|||
Frog   523 GD-RSSLQEQVPMVVGSVTAGLIFIIAVVIIVIVCFSRKQRNDAESEYTEKLQQYMVPGMKLYID 586

Human   611 PFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQ 675
            ||||||||||||:||||||:||||||||||||||||||||||||.||||..|||||||.||||:|
Frog   587 PFTYEDPNEAVRDFAKEIDISCVKIEEVIGAGEFGEVCRGRLKQAGRREQLVAIKTLKAGYTEQQ 651

Human   676 RRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLR 740
            |||||.|||||||||||||||||||||:|||||||||||||.|||||||:||||||||||||:||
Frog   652 RRDFLGEASIMGQFDHPNIIRLEGVVTRSRPVMILTEFMENGALDSFLRMNDGQFTVIQLVGILR 716

Human   741 GIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWT 805
            |||:||||||||||||||||||||||||||||||||||||||||:..||||||||||||||||||
Frog   717 GIASGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLENSRSDPTYTSSLGGKIPIRWT 781

Human   806 APEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQL 870
            |||||:|||||||||||||||||||||||||||||||||||||||:|||||||||||||.|||||
Frog   782 APEAISYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQL 846

Human   871 MLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLD 935
            |||||:|||||||||||||::|||||||||||||.:.||:|:||.||||||||||||.||.|||:
Frog   847 MLDCWLRDRNLRPKFSQIVSSLDKLIRNAASLKVTSPAQAGVSQQLLDRTVPDYTTFPTVSDWLE 911

Human   936 AIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQDMRLQMNQTLPVQV 998
            |||||:|:|:|:||||.||.|||||||||||||||||||||||:|:|:|||||||:|||||||
Frog   912 AIKMGQYQENFLSAGFTSFHLVAQMTAEDLLRIGVTLAGHQKKLLNSVQDMRLQMSQTLPVQV 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPHB3	NP_004434.2	EphR_LBD_B3	39..211	CDD:198446	144/171 (84%)
		Ephrin_rec_like	<284..316	CDD:311571	19/31 (61%)
		fn3	341..436	CDD:365830	68/94 (72%)
		FN3	<473..542	CDD:238020	44/69 (64%)
		EphA2_TM	<581..628	CDD:373140	37/47 (79%)
		PTKc_EphR_B	628..896	CDD:173638	246/267 (92%)
		SAM_superfamily	922..990	CDD:387673	55/67 (82%)
ephb3	XP_002935194.1	EphR_LBD	18..190	CDD:383093	144/171 (84%)
		FN3	319..423	CDD:238020	76/107 (71%)
		FN3	428..518	CDD:238020	56/89 (63%)
		EphA2_TM	<556..604	CDD:373140	37/47 (79%)
		PTKc_EphR_B	604..872	CDD:173638	246/267 (92%)
		SAM_EPH-B3	898..966	CDD:188952	55/67 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	492	1.000	Domainoid score	I3878
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20938
Inparanoid	1	1.050	1590	1.000	Inparanoid score	I1225
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D33462at32523
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		oto149030
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8752
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.190